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Source: Hypertension
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Total 48 results found since Jan 2013.
Aberrant Splicing Induced by Dysregulated Rbfox2 Produces Enhanced Function of CaV1.2 Calcium Channel and Vascular Myogenic Tone in HypertensionNovelty and Significance Vascular Myogenic Tone
Calcium influx from activated voltage-gated calcium channel CaV1.2 in vascular smooth muscle cells is indispensable for maintaining myogenic tone and blood pressure. The function of CaV1.2 channel can be optimized by alternative splicing, one of post-transcriptional modification mechanisms. The splicing factor Rbfox2 is known to regulate the CaV1.2 pre-mRNA alternative splicing events during neuronal development. However, Rbfox2’s roles in modulating the key function of vascular CaV1.2 channel and in the pathogenesis of hypertension remain elusive. Here, we report that the proportion of CaV1.2 channels with alternative e...
Source: Hypertension - November 8, 2017 Category: Cardiology Authors: Yingying Zhou, Jia Fan, Huayuan Zhu, Li Ji, Wenyong Fan, Isha Kapoor, Yue Wang, Yuan Wang, Guoqing Zhu, Juejin Wang Tags: Ion Channels/Membrane Transport, Vascular Biology, Hypertension Original Articles Source Type: research
Angiotensin II Type 1 Receptor Mechanoactivation Involves RGS5 (Regulator of G Protein Signaling 5) in Skeletal Muscle ArteriesNovelty and Significance G Protein Signaling and Vasoconstriction
Studies suggest that arteriolar pressure–induced vasoconstriction can be initiated by GPCRs (G protein–coupled receptors), including the AT1R (angiotensin II type 1 receptor). This raises the question, are such mechanisms regulated by negative feedback? The present studies examined whether RGS (regulators of G protein signaling) proteins in vascular smooth muscle cells are colocalized with the AT1R when activated by mechanical stress or angiotensin II and whether this modulates AT1R-mediated vasoconstriction. To determine whether activation of the AT1R recruits RGS5, an in situ proximity ligation assay was performed in...
Source: Hypertension - November 8, 2017 Category: Cardiology Authors: Kwangseok Hong, Min Li, Zahra Nourian, Gerald A. Meininger, Michael A. Hill Tags: Basic Science Research, Cell Signaling/Signal Transduction, Vascular Biology, Hypertension Original Articles Source Type: research
STIM2 (Stromal Interaction Molecule 2)-Mediated Increase in Resting Cytosolic Free Ca2+ Concentration Stimulates PASMC Proliferation in Pulmonary Arterial HypertensionNovelty and Significance Pulmonary Hypertension
An increase in cytosolic free Ca2+ concentration ([Ca2+]cyt) in pulmonary artery smooth muscle cells (PASMCs) triggers pulmonary vasoconstriction and stimulates PASMC proliferation leading to vascular wall thickening. Here, we report that STIM2 (stromal interaction molecule 2), a Ca2+ sensor in the sarcoplasmic reticulum membrane, is required for raising the resting [Ca2+]cyt in PASMCs from patients with pulmonary arterial hypertension (PAH) and activating signaling cascades that stimulate PASMC proliferation and inhibit PASMC apoptosis. Downregulation of STIM2 in PAH-PASMCs reduces the resting [Ca2+]cyt, whereas overexpre...
Source: Hypertension - February 7, 2018 Category: Cardiology Authors: Shanshan Song, Shane G. Carr, Kimberly M. McDermott, Marisela Rodriguez, Aleksandra Babicheva, Angela Balistrieri, Ramon J. Ayon, Jian Wang, Ayako Makino, Jason X.-J. Yuan Tags: Pulmonary Hypertension, Vascular Disease Original Articles Source Type: research
