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GALR1/GALR2 Knockdown rats block the Depression and Anxiogenic effects induced by GAL(1-15): The Heterodimer GALR1/GALR2 as a target of GAL(1-15)
The Galanin N-terminal fragment(1-15) [GAL(1-15)] induces depressant-and anxiogenic-like actions. In this work, we have studied the role of GALR2 and GALR1 on the effects of GAL(1-15) in the Forced Swimming Test (FST) and Open Field Test (OFT) using siRNA GALR2 and GALR1 knockdown rats.
Source: Neuropeptides - October 1, 2017 Category: Neuroscience Authors: Carmelo Mill ón, Flores-Burgess Antonio, Narvaez Manuel, O Borroto-Escuela Dasiel, Santín Luis, Parrado Concención, Narvaez Jose Angel, Fuxe Kjell, Diaz-Cabiale Zaida Source Type: research

A role for Galanin N-terminal fragment (1-15) In anxiety and depression in rats
Galanin (GAL) is involved in several functions including mood regulation. The GAL N-terminal fragment (1-15) [GAL(1-15)] also participates at central level and a differential role of GAL(1-15) compared with GAL has been proposed. In this work we have analysed if GAL(1-15) contributes to depression- and anxiety -related behaviours using the forced swimming test, tail suspension test, open field and light/dark test. We tested the involvement of the GAL receptor 2 (GALR2) in GAL(1-15) effects with the GAL receptor antagonist M871 and with an in vivo model of siRNA GALR2 knockdown rats.
Source: Neuropeptides - October 1, 2017 Category: Neuroscience Authors: Carmelo Mill ón, Antonio Flores-Burguess, Manuel Narváez, Dasiel Borroto-Escuela, Luis Santín, Jose Angel Narváez, Kjell Fuxe, Zaida Díaz-Cabiale Source Type: research