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< em > Chelidonium majus < /em > Induces Apoptosis of Human Ovarian Cancer Cells Via ATF3-Mediated Regulation of Foxo3a by Tip60
This study demonstrated that Chelidonium majus upregulated the expression of ATF3 and Tip60 and promoted Foxo3a nuclear translocation, ultimately increasing the level of Bcl-2-associated X protein (Bax) protein. ATF3 overexpression stimulated Tip60 expression, while ATF3 inhibition by siRNA repressed Tip60 expression. Furthermore, siRNA-mediated Tip60 inhibition significantly promoted Foxo3a phosphorylation, leading to blockade of Foxo3a translocation into the nucleus. Thus, we were able to deduce that ATF3 mediates the regulation of Foxo3a by Tip60. Moreover, siRNA-mediated Foxo3a inhibition suppressed the expression of B...
Source: Journal of Microbiology and Biotechnology - March 14, 2022 Category: Biotechnology Authors: Lei Shen Soon Lee Jong Cheon Joo Eunmi Hong Zhen Yang Cui Eunbi Jo Soo Jung Park Hyun-Jin Jang Source Type: research

Sevoflurane postconditioning reduces hypoxia/reoxygenation injury in cardiomyocytes via up-regulating heat shock proteins 70
In conclusion, this study demonstrated that SPostC reduced the HR injury of cardiomyocytes by inducing HSP70 expression.PMID:34226409 | DOI:10.4014/jmb.2103.03040
Source: Journal of Microbiology and Biotechnology - July 6, 2021 Category: Biotechnology Authors: Jun Zhang Haiyan Wang Xizhi Sun Source Type: research

Induction of IFN- β through both TLR-3- and RIG-I-mediated signaling pathways in canine respiratory epithelial cells infected with H3N2 canine influenza virus
In this study, we aimed to determine the signaling pathways leading to the induction of IFN-β in a canine respiratory epithelial cell line (i.e., KU-CBE) infected with the H3N2 subtype of CIV. Small interfering RNAs (siRNAs) specific to pattern recognition receptors (PRRs) and transcription factors were used to block the IFN-β-induction signals in H3N2 CIV-infected KU-CBE cells. Among the PRRs, only the TLR3 and RIG-I expression levels significantly (P < 0.001) increased in CIV-infected cells. Following transfection with siRNA specific to TLR3 (siTLR3) or RIG-I (siRIG-I), the mRNA expression levels of IFN-β significa...
Source: Journal of Microbiology and Biotechnology - June 8, 2021 Category: Biotechnology Authors: Woo-Jung Park Sang-Hoon Han Dong-Hwi Kim Young-Jo Song Joong-Bok Lee Seung-Yong Park Chang-Seon Song Sang-Won Lee In-Soo Choi Source Type: research

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