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Source: Cardiovascular Toxicology
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Total 22 results found since Jan 2013.
PCSK9 Knockdown Can Improve Myocardial Ischemia/Reperfusion Injury by Inhibiting Autophagy
This study investigates the effect and mechanism of proprotein convertase subtilisin/Kexin type 9 (PCSK9) on myocardial ischemia-reperfusion injury (MIRI) and provides a reference for clinical prevention and treatment of acute myocardial infarction (AMI). We established a rat model of myocardial ischemia/reperfusion (I/R) and AC16 hypoxia/reoxygenation (H/R) model. A total of 48 adult 7-week-old male Sprague-Dawley rats were randomly assigned to three groups (n = 16): control, I/R, and I/R + SiRNA. In I/R and I/R + siRNA groups, myocardial ischemia was induced via occlusion of the left anterior descending branch (LAD) of t...
Source: Cardiovascular Toxicology - November 7, 2022 Category: Cardiology Authors: Guangwei Huang Xiyang Lu Zonggang Duan Kai Zhang Lei Xu Hailong Bao Xinlin Xiong Muzhi Lin Chao Li Yunquan Li Haiyan Zhou Zhenhua Luo Wei Li Source Type: research
miR-33a-5p Suppresses ox-LDL-Stimulated Calcification of Vascular Smooth Muscle Cells by Targeting METTL3
Cardiovasc Toxicol. 2021 May 24. doi: 10.1007/s12012-021-09663-0. Online ahead of print.ABSTRACTOxidized low-density lipoprotein (ox-LDL) accumulation in the vascular wall plays a pivotal role in the development of atherosclerosis and vascular calcification. However, few studies focus on the regulatory roles of microRNAs in ox-LDL stimulated vascular calcification. The aim of the present study was to investigate how miR-33a-5p regulated vascular calcification stimulated by ox-LDL. In the present study, miR-33a-5p was downregulated during vascular smooth muscle cells (VSMCs) calcification and upon ox-LDL treatment. ox-LDL s...
Source: Cardiovascular Toxicology - May 24, 2021 Category: Cardiology Authors: Ruimei Han Jian Luo Lingpeng Wang Li Li Hongchao Zheng Source Type: research
Indoleamine 2,3-Dioxygenase 1 (IDO1) Promotes Cardiac Hypertrophy via a PI3K-AKT-mTOR-Dependent Mechanism
Cardiovasc Toxicol. 2021 May 21. doi: 10.1007/s12012-021-09657-y. Online ahead of print.ABSTRACTIndoleamine 2,3-dioxygenase 1 (IDO1) is an enzyme for tryptophan metabolism, involved in immune cell differentiation/maturation and cancer biology. IDO1 is also expressed in cardiomyocytes, but its roles in the cardiovascular system are not fully understood. Here, we reported the functions of IDO1 during cardiac hypertrophy. Quantitative real-time PCR and Western blot experiments demonstrated the upregulation of IDO1 mRNA and protein levels in human and hypertrophic mouse hearts, as well as in angiotensin II (Ang II)-induced hyp...
Source: Cardiovascular Toxicology - May 22, 2021 Category: Cardiology Authors: Yang Liu Shuang Li Zhanqun Gao Shuangjia Li Qingyun Tan Yanmei Li Dongwei Wang Qingdong Wang Source Type: research
Anti-apoptotic Effect of MiR-223-3p Suppressing PIK3C2A in Cardiomyocytes from Myocardial Infarction Rat Through Regulating PI3K/Akt Signaling Pathway
Cardiovasc Toxicol. 2021 May 17. doi: 10.1007/s12012-021-09658-x. Online ahead of print.ABSTRACTWe aimed to explore the regulatory mechanism of the axis of miR-223-3p-PIK3C2A-PI3K/Akt on cardiomyocyte apoptosis in rats with myocardial infarction. Thirty 8-week-old healthy male SD rats were used for establishing the sham group and the model group, with HE staining, TUNEL staining, and TTC staining performed. After the identification of the targeting relationship between PIK3C2A and miR-223-3p, experimental rats were randomly divided into seven groups by plasmid transfection, including the Blank group, negative control (NC) ...
Source: Cardiovascular Toxicology - May 17, 2021 Category: Cardiology Authors: Liu Xiaoyu Zhang Wei Zhao Ming Jia Guowei Source Type: research
FABP5 Deficiency Impairs Mitochondrial Function and Aggravates Pathological Cardiac Remodeling and Dysfunction
Cardiovasc Toxicol. 2021 Apr 30. doi: 10.1007/s12012-021-09653-2. Online ahead of print.ABSTRACTFatty acid-binding protein 5 (FABP5) is an important member of the FABP family and plays a vital role in the metabolism of fatty acids. However, few studies have examined the role of FABP5 in pathological cardiac remodeling and heart failure. The aim of this study was to explore the role of FABP5 in transverse aortic constriction (TAC)-induced pathological cardiac remodeling and dysfunction in mice. Quantitative RT-PCR (qRT-PCR) and western blotting (WB) analysis showed that the levels of FABP5 mRNA and protein, respectively, we...
Source: Cardiovascular Toxicology - April 30, 2021 Category: Cardiology Authors: Shanquan Gao Guoqi Li Yihui Shao Zhipeng Wei Shan Huang Feiran Qi Yao Jiao Yulin Li Congcong Zhang Jie Du Source Type: research
