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New perspectives in triple-negative breast cancer therapy based on treatments with TGF β1 siRNA and doxorubicin.
In this study, a combined doxorubicin (DOX) and small interfering RNA (siRNA) therapy is proposed as therapeutic strategy for targeting TGFβ1 gene. Hs578T cell line is used as in vitro model for TNBC, wherein TGFβ1siRNA therapy is employed to enhance therapeutic effects. Cell proliferation rate is measured using an MTT test, and morphological alterations are assed using microscopically approached, while gene expression is determined by qRT-PCR analysis. The combined treatment of TGFβ1siRNA and DOX reduced levels of cell proliferation and mitochondrial activity and promoted the alteration of cell morphology (dark-field m...
Source: Molecular and Cellular Biochemistry - September 3, 2020 Category: Biochemistry Authors: Ciocan-Cȃrtiţă CA, Jurj A, Raduly L, Cojocneanu R, Moldovan A, Pileczki V, Pop LA, Budişan L, Braicu C, Korban SS, Berindan-Neagoe I Tags: Mol Cell Biochem Source Type: research

Adhesion to fibronectin induces p27(Kip1) nuclear accumulation through down-regulation of Jab1 and contributes to cell adhesion-mediated drug resistance (CAM-DR) in RPMI 8,226 cells.
In conclusion, our data suggest that Jab1 plays an important role in CAM-DR, which depends on pSer10-p27(Kip1)-mediated subcellular localization of p27(Kip1). The understanding of this novel molecular mechanism may prove valuable in designing new therapeutic approaches for CAM-DR in Multiple myeloma. PMID: 24170542 [PubMed - as supplied by publisher]
Source: Molecular and Cellular Biochemistry - October 30, 2013 Category: Biochemistry Authors: Fei M, Hang Q, Hou S, He S, Ruan C Tags: Mol Cell Biochem Source Type: research

Interleukin-22 promotes lung cancer cell proliferation and migration via the IL-22R1/STAT3 and IL-22R1/AKT signaling pathways.
In this study, we found that expression of IL-22 was upregulated in tumor tissues and serum from patients with recurrent non-small cell lung cancer (NSCLC) as compared to primary NSCLC samples. Treatment with IL-22 promoted cell proliferation and enhanced migration and invasion in A549 and H125 cell lines. Furthermore, we revealed that phosphorylation of STAT3 and AKT was highly induced by treatment with IL-22 via IL-22R1. IL-22R1 was also consistently overexpressed in recurrent NSCLC tissues. Finally, we found that siRNA-mediated depletion of IL-22R1 completely abrogated the effects of IL-22 treatment on cell proliferatio...
Source: Molecular and Cellular Biochemistry - March 17, 2016 Category: Biochemistry Authors: Bi Y, Cao J, Jin S, Lv L, Qi L, Liu F, Geng J, Yu Y Tags: Mol Cell Biochem Source Type: research

Inhibition of protein kinase CK2 sensitizes non-small cell lung cancer cells to cisplatin via upregulation of PML.
In conclusion, inhibiting CK2 can enhance sensitivity of CDDP to NSCLC cancer cells through PML. PMID: 28744813 [PubMed - as supplied by publisher]
Source: Molecular and Cellular Biochemistry - July 25, 2017 Category: Biochemistry Authors: Yang B, Yao J, Li B, Shao G, Cui Y Tags: Mol Cell Biochem Source Type: research

Glucocorticoids attenuate the sensitivity of glucocorticoid-resistant lymphoid cells to doxorubicin via reduction in OCTN2.
In this study, we examined whether GCs affected the sensitivities to vincristine (VCR)/doxorubicin (DOX) and the expression of drug transporters in GC-resistant cells. The dexamethasone (DEX)/prednisolone (PSL)-resistant lymphoid and non-lymphoid cell lines Raji and HL60 were cultured with DEX for 7 days and then treated with VCR or DOX for 3 days. Seven days of DEX treatment increased the IC50s of both VCR and DOX in Raji cells but not in HL60 cells. The mRNA and protein expression levels of organic cation/carnitine transporter (OCTN) 2, one of the drug uptake transporters expressed in both cell lines, were decreased on...
Source: Molecular and Cellular Biochemistry - May 15, 2019 Category: Biochemistry Authors: Akaihata M, Shikama Y, Matsumoto Y, Ono T, Kimura J, Hosoya M Tags: Mol Cell Biochem Source Type: research

miR-874-3p mitigates cisplatin resistance through modulating NF- κB/inhibitor of apoptosis protein signaling pathway in epithelial ovarian cancer cells
Mol Cell Biochem. 2021 Oct 30. doi: 10.1007/s11010-021-04271-6. Online ahead of print.ABSTRACTThe resistance to cisplatin, the most common platinum chemotherapy drug, may confine the efficacy of treatment in epithelial ovarian cancer patients. Aberrant expression of inhibitor of apoptosis proteins set the stage for resistance to cisplatin in EOC; besides, chemosensitivity in EOC can be chalked up to dysregulation of specific miRNAs. Herein, we investigated whether there is a potential correlation between miR-874-3p and the X-chromosome-linked inhibitor of apoptosis, a member of the IAP protein family in cisplatin-resistant...
Source: Molecular and Cellular Biochemistry - October 30, 2021 Category: Biochemistry Authors: Ying Wang Chenming Yan Junxia Qi Chunyan Liu Juan Yu Huabin Wang Source Type: research