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Source: Molecular and Cellular Biochemistry

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Total 162 results found since Jan 2013.

miR-940 regulates the inflammatory response of chondrocytes by targeting MyD88 in osteoarthritis.
In conclusion, the pathogenesis of OA can be regulated by miR-940/MyD88 axis, which can be achieved through the combined signaling mechanism of MyD88/NF-κB signaling, induced with the help of IL-1β. PMID: 31435813 [PubMed - as supplied by publisher]
Source: Molecular and Cellular Biochemistry - August 20, 2019 Category: Biochemistry Authors: Cao J, Liu Z, Zhang L, Li J Tags: Mol Cell Biochem Source Type: research

Neuraminidase 1 regulates proliferation, apoptosis and the expression of Cadherins in mammary carcinoma cells.
Abstract The link between Neuraminidase 1 (Neu1) and cancer development has been highlighted in numerous studies. In an effort to understand the role of Neu1 in mammary carcinoma cells, we evaluated the effect of Neu1 on controlling cell proliferation and apoptosis, as well as regulating the expression of cadherins. By blocking the activity of Neu1 with oseltamivir phosphate or using siRNA to silence the Neu1 protein, we observed suppression of cell growth in MCF-7 and MDA-MB-231 cells. Enhanced cleaved caspase 3 expression was demonstrated in breast cancer cells treated with oseltamivir phosphate or in Neu1 knock...
Source: Molecular and Cellular Biochemistry - September 11, 2019 Category: Biochemistry Authors: Thulasiraman P, Kerr K, McAlister K, Hardisty S, Wistner A, McCullough I Tags: Mol Cell Biochem Source Type: research

Insulin-induced de novo lipid synthesis occurs mainly via mTOR-dependent regulation of proteostasis of SREBP-1c.
Abstract Insulin stimulates de novo lipid synthesis in the liver and in cultured hepatocytes via its ability to activate sterol regulatory element-binding protein 1c (SREBP-1c). Although PI3K-AKT-mTORC1-p70S6K-signaling kinases are known to drive feed-forward expression of SREBP-1c, the identity of the phosphorylated amino acid residue(s) putatively involved in insulin-stimulated de novo lipogenesis remains elusive. We obtained in silico and mass spectrometry evidence, that was combined with siRNA strategies, to discover that insulin-induced phosphorylation of serine 418, serine 419, and serine 422 in rat SREBP-1c...
Source: Molecular and Cellular Biochemistry - September 19, 2019 Category: Biochemistry Authors: Dong Q, Majumdar G, O'Meally RN, Cole RN, Elam MB, Raghow R Tags: Mol Cell Biochem Source Type: research

Beneficial effect of ER stress preconditioning in protection against FFA-induced adipocyte inflammation via XBP1 in 3T3-L1 adipocytes.
Abstract Adipose tissue inflammation is closely associated with the development of obesity and insulin resistance. Free fatty acids (FFAs) are a major inducer of obesity-related insulin resistance. Previously, we reported that endoplasmic reticulum (ER) stress potentially mediated retinal inflammation in diabetic retinopathy. The unfolded protein response (UPR) protects cells against damage induced by oxidative stress. X-box binding protein 1 (XBP1) plays a major role in protecting cells by modulating the UPR. However, the link between ER stress and adipocyte inflammation has been poorly investigated. In the prese...
Source: Molecular and Cellular Biochemistry - October 15, 2019 Category: Biochemistry Authors: Wang M, Chen X, Zheng Z, Yu S, Zhou B, Liu Y, Liu D, Chen Y, Qian X Tags: Mol Cell Biochem Source Type: research

Transforming growth factor- β1 enhances proliferative and metastatic potential by up-regulating lymphoid enhancer-binding factor 1/integrin αMβ2 in human renal cell carcinoma.
Transforming growth factor-β1 enhances proliferative and metastatic potential by up-regulating lymphoid enhancer-binding factor 1/integrin αMβ2 in human renal cell carcinoma. Mol Cell Biochem. 2019 Dec 17;: Authors: Liu Y, Shang D Abstract Renal cell carcinoma (RCC) is a kind of malignant tumor with high recurrence, and it is urgent to find molecular markers for diagnosis and prognosis of RCC. Our study investigated the expression and function of integrin αMβ2 in RCC cells, aiming to understand the role of integrin αMβ2 in RCC and develop new therapeutic target for RCC. Overexpression and knock...
Source: Molecular and Cellular Biochemistry - December 16, 2019 Category: Biochemistry Authors: Liu Y, Shang D Tags: Mol Cell Biochem Source Type: research

Hypoxia induces the activation of hepatic stellate cells through the PVT1-miR-152-ATG14 signaling pathway.
Abstract Increasing studies have indicated that hypoxia serves as a pivotal microenvironmental factor that facilitates activation of hepatic stellate cells (HSCs). However, the mechanism by which hypoxia activates HSCs is not clear. Here, we demonstrated that plasmacytoma variant translocation 1 (PVT1) and autophagy were overexpressed in liver fibrotic specimens. In primary mouse HSCs, both PVT1 and autophagy were induced by hypoxia. Further study showed that hypoxia-induced autophagy depended on expression of PVT1 and miR-152 in HSCs. Luciferase reporter assay indicated that autophagy-related gene 14 (ATG14) was ...
Source: Molecular and Cellular Biochemistry - December 20, 2019 Category: Biochemistry Authors: Yu F, Dong B, Dong P, He Y, Zheng J, Xu P Tags: Mol Cell Biochem Source Type: research

MALAT1 affects hypoxia-induced vascular endothelial cell injury and autophagy by regulating miR-19b-3p/HIF-1 α axis.
MALAT1 affects hypoxia-induced vascular endothelial cell injury and autophagy by regulating miR-19b-3p/HIF-1α axis. Mol Cell Biochem. 2020 Jan 13;: Authors: Liu H, Shi C, Deng Y Abstract Cardiovascular disease has become the leading cause of death in the world. Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) plays an important role in cardiovascular disease, such as stroke. However, the role of MALAT1 in hypoxia (HYP)-induced vascular endothelial cells (VECs) remains unclear. In the present study, HYP-treated human umbilical vein endothelial cells (HUVECs) were utilized to simulate HY...
Source: Molecular and Cellular Biochemistry - January 12, 2020 Category: Biochemistry Authors: Liu H, Shi C, Deng Y Tags: Mol Cell Biochem Source Type: research

Purine signaling regulating HSCs inflammatory cytokines secretion, activation, and proliferation plays a critical role in alcoholic liver disease.
Abstract Purine signaling pathway plays an important role in inflammation and tissue damage. To investigate the role of purine signaling pathway in acute alcoholic liver injury and chronic alcoholic liver fibrosis, we replicated two animal models and two cellular models. We found that body weights, liver indexes, serum biochemical parameters, serum fibrosis indexes, and pathological and immunohistochemical results had significant changes in two treatment groups compared with two control groups. In addition, gene expressions of purine receptors, inflammatory cytokines, fibrogenic cytokines, and inflammasomes increa...
Source: Molecular and Cellular Biochemistry - January 26, 2020 Category: Biochemistry Authors: Shan L, Jiang T, Ci L, Liu Z, Lv X, Li J Tags: Mol Cell Biochem Source Type: research

Arctigenin induces necroptosis through mitochondrial dysfunction with CCN1 upregulation in prostate cancer cells under lactic acidosis.
Abstract Arctigenin, a mitochondrial complex I inhibitor, has been identified as a potential anti-tumor agent, but the involved mechanism still remains elusive. Herein, we studied the underlying mechanism(s) of action of arctigenin on acidity-tolerant prostate cancer PC-3AcT cells in the lactic acid-containing medium. At concentration showing no toxicity on normal prostate epithelial RWPE-1 and HPrEC cells, arctigenin alone or in combination with docetaxel induced significant cytotoxicity in PC-3AcT cells compared to parental PC-3 cells. With arctigenin treatment, reactive oxygen species (ROS) levels, annexin V-PE...
Source: Molecular and Cellular Biochemistry - February 16, 2020 Category: Biochemistry Authors: Lee YJ, Nam HS, Cho MK, Lee SH Tags: Mol Cell Biochem Source Type: research

ILK silencing inhibits migration and invasion of more invasive glioblastoma cells by downregulating ROCK1 and Fascin-1.
In this study, we used two brain cell lines, the non-invasive neuroglioma H4 cells, and the highly invasive glioblastoma A172 cells, which express ILK in much higher levels than H4. We studied the effect of ILK silencing on the metastatic behavior of glioblastoma cells in vitro and elucidate the underlying molecular mechanism. We showed that siRNA-mediated silencing of ILK inhibits cell migration and invasion of the highly invasive A172 cells while it does not affect the migratory and invasive capacity of H4 cells. These data were also supported by respective changes in the expression of Rho-associated kinase 1 (ROCK1), fa...
Source: Molecular and Cellular Biochemistry - June 5, 2020 Category: Biochemistry Authors: Louca M, Zaravinos A, Stylianopoulos T, Gkretsi V Tags: Mol Cell Biochem Source Type: research

Growth factor receptor bound protein-7 regulates proliferation, cell cycle, and mitochondrial apoptosis of thyroid cancer cells via MAPK/ERK signaling.
Abstract It is of great significance to explore the molecular mechanism of thyroid cancer (TC) pathogenesis for its improvement and therapy. Growth factor receptor bound protein-7 (GRB7) has been regarded as an important regulatory gene in the developments of various malignant tumors. Our study aimed to illustrate the role of GRB7 in the TC pathology mechanism. Firstly, GRB7 was found to be significantly upregulated in 49 cases of TC tissues and 5 TC cell lines by using real-time quantitative polymerase chain reaction (RT-qPCR) and western blotting. Silencing GRB7 with siRNA dramatically inhibited proliferation an...
Source: Molecular and Cellular Biochemistry - June 22, 2020 Category: Biochemistry Authors: Tang H, Yang P, Yang X, Peng S, Hu X, Bao G Tags: Mol Cell Biochem Source Type: research

Speedy/RINGO protein interacts with ERK/MAPK and PI3K/AKT pathways in SH-SY5Y neuroblastoma cells.
This study provides information about a possible interaction of Speedy/RINGO with PI3K/AKT and ERK/MAPK pathways in SH-SY5Y cells for the first time. It will not only help to better understand the cancer-prone interactions of these pathways but also enable us to identify the appropriate molecular targets for developing efficient treatment strategies. PMID: 32602013 [PubMed - as supplied by publisher]
Source: Molecular and Cellular Biochemistry - June 28, 2020 Category: Biochemistry Authors: Kaya Y, Kucukvardar S, Yildiz A Tags: Mol Cell Biochem Source Type: research

Isoflurane promotes proliferation of squamous cervical cancer cells through mTOR-histone deacetylase 6 pathway.
In conclusion, Isoflurane enhanced proliferation of cervical cancer cells through upregulation of histone deacetylase 6, which was associated with mTOR-dependent pathway, but not AKT-mediated pathway. PMID: 32833118 [PubMed - as supplied by publisher]
Source: Molecular and Cellular Biochemistry - August 23, 2020 Category: Biochemistry Authors: Zhang W, Xue F, Xie S, Chen C, Li J, Zhu X Tags: Mol Cell Biochem Source Type: research

Ectopic expression of 35  kDa and knocking down of 78 kDa SG2NAs induce cytoskeletal reorganization, alter membrane sialylation, and modulate the markers of EMT.
Ectopic expression of 35 kDa and knocking down of 78 kDa SG2NAs induce cytoskeletal reorganization, alter membrane sialylation, and modulate the markers of EMT. Mol Cell Biochem. 2020 Oct 20;: Authors: Gupta R, Kumar G, Jain BP, Chandra S, Goswami SK Abstract SG2NA is a protein of the striatin family that organizes STRIPAK complexes. It has splice variants expressing differentially in tissues. Its 78 kDa isoform regulates cell cycle, maintains homeostasis in the endoplasmic reticulum, and prevents oxidative injuries. The 35 kDa variant is devoid of the signature WD-40 repeats in the carboxy termin...
Source: Molecular and Cellular Biochemistry - October 20, 2020 Category: Biochemistry Authors: Gupta R, Kumar G, Jain BP, Chandra S, Goswami SK Tags: Mol Cell Biochem Source Type: research

TAK1 is involved in sodium L-lactate-stimulated p38 signaling and promotes apoptosis.
In this study, we suggested that TAK1 plays an important role in L-lactate-stimulated activation of p38 affecting apoptosis in HeLa cells. PMID: 33111211 [PubMed - as supplied by publisher]
Source: Molecular and Cellular Biochemistry - October 27, 2020 Category: Biochemistry Authors: Da Q, Yan Z, Li Z, Han Z, Ren M, Huang L, Zhang X, Liu J, Wang T Tags: Mol Cell Biochem Source Type: research