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Source: Biology of Reproduction
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Total 100 results found since Jan 2013.
The IL6/sIL-6R α trans-signaling increases PGE2 production in human granulosa cells
In conclusion, IL6 trans-signaling upregulates the expression of PTGS2 and increases the production of PGE2 via the JAK2/STAT3/SOCS3 signaling pathway in hGL cells. Our findings provide insights into the molecular mechanisms by which IL6 trans-signaling may potentially modulate the event of ovulation in human ovaries.PMID:34198336 | DOI:10.1093/biolre/ioab128
Source: Biology of Reproduction - July 1, 2021 Category: Reproduction Medicine Authors: Sai-Jiao Li Hsun-Ming Chang Jiamin Xie Jeremy H Wang Jing Yang Peter C K Leung Source Type: research
Impact of growth hormone-releasing hormone (GHRH) antagonist on Decidual stromal cell growth and apoptosis in vitro
Biol Reprod. 2021 Nov 18:ioab214. doi: 10.1093/biolre/ioab214. Online ahead of print.ABSTRACTEndometrial stromal cells remodeling is critical during human pregnancy. GHRH and its functional receptor have been shown to be expressed in gynecological cancer cells and eutopic endometrial stromal cells. Recent studies have demonstrated the potential clinical uses of antagonists of GHRH as effective antitumor agents because of its directly antagonistic effect on the locally produced GHRH in gynecological tumors. However, the impact of GHRH antagonists on normal endometrial stromal cell growth remained to be elucidated. The aim o...
Source: Biology of Reproduction - November 18, 2021 Category: Reproduction Medicine Authors: Hsien-Ming Wu Liang-Hsuan Chen Andrew V Schally Hong-Yuan Huang Yung-Kuei Soong Peter C K Leung Hsin-Shih Wang Source Type: research
HOXA10 improves endometrial receptivity by upregulating E-cadherin
In conclusion, HOXA10 can bind to the E-cadherin promoter region and directly regulate its expression, thereby improving endometrial receptivity and subsequently increasing the embryo adhesion and implantation.PMID:35044439 | DOI:10.1093/biolre/ioac007
Source: Biology of Reproduction - January 19, 2022 Category: Reproduction Medicine Authors: Yin Bi Weiyu Huang Lifang Yuan Saiqiong Chen Shengbin Liao Xiaoqian Fu Bo Liu Yihua Yang Source Type: research
