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Source: Current Issues in Molecular Biology
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Total 225 results found since Jan 2013.
Lipid Nanoparticles: A Novel Gene Delivery Technique for Clinical Application
Curr Issues Mol Biol. 2022 Oct 19;44(10):5013-5027. doi: 10.3390/cimb44100341.ABSTRACTLipid nanoparticles (LNPs) are an emerging vehicle for gene delivery that accommodate both nucleic acid and protein. Based on the experience of therapeutic liposomes, current LNPs have been developed based on the chemistry of lipids and RNA and on the biology of human disease. LNPs have been used for the development of Onpattro, an siRNA drug for transthyretin-mediated amyloidosis, in 2018. The subsequent outbreak of COVID-19 required a vaccine for its suppression. LNP-based vaccine production received much attention for this and resulted...
Source: Current Issues in Molecular Biology - October 26, 2022 Category: Molecular Biology Authors: Ryuichi Mashima Shuji Takada Source Type: research
Cooperative Binding of SRSF3 to Structured 3'ss- α Exon RNA during α Exon Inclusion in the ZO-1 mRNA
Curr Issues Mol Biol. 2023 Jan 9;45(1):593-603. doi: 10.3390/cimb45010039.ABSTRACTZO-1α+ and ZO-1α- proteins are expressed in hermetic and leaky tight junctions, respectively. Two cis-acting distant exonic elements partly activate the 240 nucleotide-long α exon producing the ZO-1α+ isoform. However, the elements within and around the α exon and their respective factors involved in its splicing are unknown. To study the dynamic interaction between SRSF3 and its bioinformatically predicted target sites around the 3'ss upstream of the α exon during its activation, we performed EMSA, crosslinking, and in vivo splicing as...
Source: Current Issues in Molecular Biology - January 20, 2023 Category: Molecular Biology Authors: Tea Anastasia Ruiz-Luis Carlos Ortu ño-Pineda Jos é Manuel Galindo-Rosales Odila Saucedo-C árdenas Jes ús Valdés Source Type: research
