• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

The role of ORC4 in enucleation of Murine Erythroleukemia (MEL) cells is similar to that in oocyte polar body extrusion.
Abstract The Origin Replication Complex subunit 4 (ORC4) is one in six subunits of the Origin Replication Complexes (ORCs) which is essential for initiating licensing at DNA replication origins and recruiting adaptor molecules necessary for various cellular processes. Previously, we reported that ORC4 also plays a vital role in polar body extrusion (PBE) during oogenesis in which half the chromosomes are extruded from the oocyte. We hypothesized that ORC4 might play a broader role in chromatin elimination. We tested its role in enucleation during the development of erythrocytes. Murine erythroleukemia (MEL) cells ...
Source: Systems Biology in Reproductive Medicine - September 23, 2020 Category: Reproduction Medicine Authors: Nguyen H, Ung A, Ward WS Tags: Syst Biol Reprod Med Source Type: research

The balance between cell survival and death in the placenta: Do neurotrophins have a role?
Syst Biol Reprod Med. 2021 Oct 6:1-10. doi: 10.1080/19396368.2021.1980132. Online ahead of print.ABSTRACTNeurotrophins (NT) are a closely related family of growth factors, which regulate the nervous system's development, maintenance, and function. Although NTs have been well studied in neuronal cells, they are also expressed in the placenta. Despite their suggested role in regulating fetoplacental development, their precise functional significance in the placenta remains elusive. NT activate two different classes of receptors. These include the Trk, tropomyosin-related kinase family of high-affinity tropomyosin-related kin...
Source: Systems Biology in Reproductive Medicine - October 7, 2021 Category: Reproduction Medicine Authors: Prachi Pathare-Ingawale Preeti Chavan-Gautam Source Type: research

Aquaporin 9 regulates Leydig cell steroidogenesis in diabetes
Syst Biol Reprod Med. 2022 Mar 30:1-14. doi: 10.1080/19396368.2022.2033350. Online ahead of print.ABSTRACTDiabetes mellitus induced hyperglycemia increases oxidative stress, which contributes to impairment of male reproductive function. Aquaporins (AQPs) belong to a transmembrane protein superfamily containing 13 isoforms (AQP0-12), differentially expressed in various organs, and play a pivotal role in male reproductive function. In the current study, we investigated the relationship between AQPs and testicular steroidogenesis under hyperglycemia in vivo and in vitro. The effect of high glucose on the role of AQPs in Leydi...
Source: Systems Biology in Reproductive Medicine - March 30, 2022 Category: Reproduction Medicine Authors: Arun Kannan Lezy Flora Mariajoseph-Antony Antojenifer Panneerselvam Chithra Loganathan Diwakar Kiduva Jothiraman Kumarasamy Anbarasu Chidambaram Prahalathan Source Type: research