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Specialty: Research
Source: Medical Science Monitor
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Total 166 results found since Jan 2013.
Expression of the Long Intergenic Non-Coding RNA (lincRNA) of the NED25 Gene Modulates the microRNA-125b, STAT3, Nitric Oxide, and Procalcitonin Signaling Pathways in Patients with Sepsis.
CONCLUSIONS Downregulation of the lincRNA of the NED25 gene was associated with sepsis in patients by modulating the signaling pathways downstream of miR-125b/STAT3/PCT/NO signaling pathway.
PMID: 29962507 [PubMed - in process]
Source: Medical Science Monitor - July 3, 2018 Category: Research Tags: Med Sci Monit Source Type: research
Effects of Tumor Necrosis Factor α (TNF-α) and Interleukina 10 (IL-10) on Intercellular Cell Adhesion Molecule-1 (ICAM-1) and Cluster of Differentiation 31 (CD31) in Human Coronary Artery Endothelial Cells.
CONCLUSIONS TNF-α and IL-10 treatment can affect the expression of ICAM-1 and CD31 in HCAEC.
PMID: 29949812 [PubMed - in process]
Source: Medical Science Monitor - June 29, 2018 Category: Research Tags: Med Sci Monit Source Type: research
A Novel Long Noncoding RNA (lncRNA), LL22NC03-N64E9.1, Promotes the Proliferation of Lung Cancer Cells and is a Potential Prognostic Molecular Biomarker for Lung Cancer.
CONCLUSIONS Expression of lncRNA, LL22NC03-N64E9.1, promoted proliferation of lung cancer cells in vitro, was highly expressed in lung cancer tissues and was associated with increased overall survival (OS), tumor size, and tumor stage in patients with lung cancer.
PMID: 29935018 [PubMed - in process]
Source: Medical Science Monitor - June 27, 2018 Category: Research Tags: Med Sci Monit Source Type: research
Aquaporin 4 Silencing Aggravates Hydrocephalus Induced by Injection of Autologous Blood in Rats.
CONCLUSIONS Our study demonstrates that silencing AQP4 aggravates hydrocephalus, indicating that AQP4 protects against hydrocephalus.
PMID: 29921834 [PubMed - in process]
Source: Medical Science Monitor - June 23, 2018 Category: Research Tags: Med Sci Monit Source Type: research
Long Noncoding RNA (lncRNA) n379519 Promotes Cardiac Fibrosis in Post-Infarct Myocardium by Targeting miR-30.
CONCLUSIONS These findings reveal a novel function of n379519-miR-30 axis as a negative regulator for the treatment of MI-induced cardiac fibrosis and the associated cardiac dysfunction.
PMID: 29889825 [PubMed - in process]
Source: Medical Science Monitor - June 13, 2018 Category: Research Tags: Med Sci Monit Source Type: research
Activation of Sonic Hedgehog Signaling Is Associated with Human Osteosarcoma Cells Radioresistance Characterized by Increased Proliferation, Migration, and Invasion.
CONCLUSIONS Activation of Shh signaling was involved in radioresistance of OS cells. Blocking this signaling can impair the radioresistance capacity of OS cells.
PMID: 29864766 [PubMed - in process]
Source: Medical Science Monitor - June 6, 2018 Category: Research Tags: Med Sci Monit Source Type: research
Steroid Receptor Coactivator-Interacting Protein (SIP) Suppresses Myocardial Injury Caused by Acute Pancreatitis.
CONCLUSIONS In conclusion, the results suggested that SIP may inhibit the inflammatory response by deactivating p65, thus reducing the myocardial damage caused by AP.
PMID: 29765014 [PubMed - in process]
Source: Medical Science Monitor - May 18, 2018 Category: Research Tags: Med Sci Monit Source Type: research
Overexpression of Pyruvate Kinase Type M2 (PKM2) Promotes Ovarian Cancer Cell Growth and Survival Via Regulation of Cell Cycle Progression Related with Upregulated CCND1 and Downregulated CDKN1A Expression.
CONCLUSIONS PKM2 may play important roles in ovarian cancer development and may be a treatment target for this cancer.
PMID: 29752805 [PubMed - in process]
Source: Medical Science Monitor - May 14, 2018 Category: Research Tags: Med Sci Monit Source Type: research
Role of Hypoxia-Inducible Factors 1 α (HIF1α) in SH-SY5Y Cell Autophagy Induced by Oxygen-Glucose Deprivation.
CONCLUSIONS Enhanced expression of HIF-1α may be related to autophagy activation in SH-SY5Y cells, thus contributing to ischemic/hypoxic brain damage.
PMID: 29724989 [PubMed - in process]
Source: Medical Science Monitor - May 8, 2018 Category: Research Tags: Med Sci Monit Source Type: research
Interleukin-22 (IL-22) Regulates Apoptosis of Paclitaxel-Resistant Non-Small Cell Lung Cancer Cells Through C-Jun N-Terminal Kinase Signaling Pathway.
CONCLUSIONS IL-22 is involved in A549 cell resistance to PTX through regulating cell apoptosis via the JNK signaling pathway.
PMID: 29723165 [PubMed - in process]
Source: Medical Science Monitor - May 4, 2018 Category: Research Tags: Med Sci Monit Source Type: research
The Sineoculis Homeobox Homolog 1 (SIX1) Gene Regulates Paclitaxel Resistance by Affecting Reactive Oxygen Species and Autophagy in Human Hepatocellular Carcinoma Cell Line HepG2.
CONCLUSIONS Knockdown of SIX1 increased cell ROS levels and autophagy, promoted cell apoptosis, and enhanced TAX sensitivity of HepG2 cells.
PMID: 29656300 [PubMed - in process]
Source: Medical Science Monitor - April 18, 2018 Category: Research Tags: Med Sci Monit Source Type: research
Baicalin, a Chinese Herbal Medicine, Inhibits the Proliferation and Migration of Human Non-Small Cell Lung Carcinoma (NSCLC) Cells, A549 and H1299, by Activating the SIRT1/AMPK Signaling Pathway.
CONCLUSIONS Baicalin, a flavonoid used in Chinese herbal medicine, inhibited the proliferation and migration of human NSCLC cells, A549 and H1299, by activating the SIRT1/AMPK signaling pathway.
PMID: 29632297 [PubMed - in process]
Source: Medical Science Monitor - April 13, 2018 Category: Research Tags: Med Sci Monit Source Type: research
Upregulation of Ubiquitin Carboxyl-Terminal Hydrolase L1 (UCHL1) Mediates the Reversal Effect of Verapamil on Chemo-Resistance to Adriamycin of Hepatocellular Carcinoma.
CONCLUSIONS Upregulation of UCHL1 enhanced the reversal effect of VER on chemo-resistance to ADM and promoted cell apoptosis. The underlying mechanism of the function of UCHL1 and the signaling pathway involved in its effect are to be investigated in our future research.
PMID: 29627846 [PubMed - in process]
Source: Medical Science Monitor - April 10, 2018 Category: Research Tags: Med Sci Monit Source Type: research
Triple Negative Breast Cancer Depends on Sphingosine Kinase 1 (SphK1)/Sphingosine-1-Phosphate (S1P)/Sphingosine 1-Phosphate Receptor 3 (S1PR3)/Notch Signaling for Metastasis.
CONCLUSIONS We found that elevated levels of pSphK1 were positive correlation with high expression of S1P, which in turn promoted metastasis of TNBC through S1P/S1PR3/Notch signaling pathway.
PMID: 29605826 [PubMed - in process]
Source: Medical Science Monitor - April 3, 2018 Category: Research Tags: Med Sci Monit Source Type: research
Cyclin Y Modulates the Proliferation, Invasion, and Metastasis of Hepatocellular Carcinoma Cells.
CONCLUSIONS In tissue samples of human HCC, and human HCC cell lines, increased expression of CCNY was significantly associated with cell proliferation and migration. Further studies are recommended to evaluate the role of CCNY as a potential diagnostic biomarker or target for treatment in human HCC.
PMID: 29557391 [PubMed - in process]
Source: Medical Science Monitor - March 22, 2018 Category: Research Tags: Med Sci Monit Source Type: research
