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Chemo-biologic combinatorial drug delivery using folate receptor-targeted dendrimer nanoparticles for lung cancer treatment
Co-administration of functionally distinct anti-cancer agents has emerged as an efficient strategy in lung cancer treatment. However, a specially designed drug delivery system is required to co-encapsulate functionally different agents, such as a combination of siRNA and chemotherapy, for targeted delivery. We developed a folic acid (FA) -conjugated polyamidoamine dendrimer (Den) -based nanoparticle (NP) system for co-delivery of siRNA against HuR mRNA (HuR siRNA) and cis-diamine platinum (CDDP) to folate receptor- α (FRA) -overexpressing H1299 lung cancer cells.
Source: Nanomedicine : Nanotechnology, Biology, and Medicine - November 16, 2017 Category: Nanotechnology Authors: Narsireddy Amreddy, Anish Babu, Janani Panneerselvam, Akhil Srivastava, Ranganayaki Muralidharan, Allshine Chen, Yan D. Zhao, Anupama Munshi, Rajagopal Ramesh Source Type: research

Targeted-gene silencing of BRAF to interrupt BRAF/MEK/ERK pathway synergized photothermal therapeutics for melanoma using a novel FA-GNR-siBRAF nanosystem
Melanoma is significantly associated with mutant BRAF gene, a suitable target for siRNA-based anti-melanoma therapy. However, a tumor-specific delivery system is a major hurdle for clinical applications. Here, we developed a novel nano-carrier, FA-GNR-siBRAF for safe topical application, which consists of folic acid (FA) as the tumor-targeting moiety, golden nanorods (GNR) providing photothermal capability to kill tumor cells under laser irradiation, and siRNA specifically silencing BRAF (siBRAF).
Source: Nanomedicine : Nanotechnology, Biology, and Medicine - April 20, 2018 Category: Nanotechnology Authors: Yujuan Zhang, Xuelin Zhan, Shanshan Peng, Ying Cai, Yu Shrike Zhang, Yanling Liu, Zhigang Wang, Yanrong Yu, Yifan Wang, Qiaofa Shi, Xiaoping Zeng, Keng Yuan, Nanjin Zhou, Rakesh Joshi, Meng Zhang, Zhuxu Zhang, Weiping Min Source Type: research

Targeted uptake of folic acid-functionalized iron oxide nanoparticles by ovarian cancer cells in the presence but not in the absence of serum
In this study the receptor specific uptake of folic acid-functionalized iron oxide nanoparticles was determined in ovarian cancer cells. It was found that the presence of serum proteins is an absolute requirement for the uptake of these nanoparticles. The described strategy for receptor-mediated uptake of nanoparticles with pre-defined surface chemistry may enable a better targeting of nanoparticles for additional therapeutic and imaging applications.Graphical Abstract: Targeted, i.e. receptor-mediated cellular uptake of folic acid (FA)-conjugated iron oxide nanoparticles is shown for particles with SiO2 coating, but not f...
Source: Nanomedicine : Nanotechnology, Biology, and Medicine - February 3, 2014 Category: Nanotechnology Authors: Annette Krais, Laura Wortmann, Laura Hermanns, Neus Feliu, Marie Vahter, Stefan Stucky, Sanjay Mathur, Bengt Fadeel Tags: Cell Biology, Cell Physiology, Receptor-Specific Uptake, Effect of Pegylation, Serum Proteins, FA-Iron Oxide NPs Source Type: research