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Source: Journal of Southern Medical University
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Total 774 results found since Jan 2013.
Role of PNPT1 in cardiomyocyte apoptosis induced by oxygen-glucose deprivation
CONCLUSION: Inhibition of PNPT1 improves mitochondrial damage and reduces degradation of apoptotic-associated mRNAs to alleviate OGD-induced apoptosis of mouse atrial myocyte.PMID:35527495 | PMC:PMC9085594 | DOI:10.12122/j.issn.1673-4254.2022.04.15
Source: Journal of Southern Medical University - May 9, 2022 Category: Universities & Medical Training Authors: X Zhang X Wang Q Li Y Chen X Zhang P Wang M Yuan H Pei Source Type: research
Cisplatin inhibits proliferation of cervical carcinoma cell line by up-regulating Stat1 expression.
CONCLUSION: The expression of Stat1 is associated with DDP sensitivity in cervical cancer cells, and Stat1 silencing can increase the sensitivity to DDP and c-Myc expression of the cells.
PMID: 25613616 [PubMed - in process]
Source: Journal of Southern Medical University - January 20, 2015 Category: Universities & Medical Training Authors: Lei RL, Xiao SS, Xue M Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research
ADAM17 knockdown increases sensitivity of SW480 cells to cetuximad.
CONCLUSIONS: ADAM17 knockdown obviously inhibits EGFR-AKT signaling pathway and increases the sensitivity of SW480 cells to tocetuximad.
PMID: 30514687 [PubMed - in process]
Source: Journal of Southern Medical University - November 30, 2018 Category: Universities & Medical Training Authors: Chen Y, Zheng K, Chen Z, Feng H, Fang W, Huang Z Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research
Silencing RRM1 gene reverses paclitaxel resistance in human breast cancer cell line MCF- 7/R by inducing cell apoptosis.
CONCLUSIONS: RRM1 gene silencing can reverse paclitaxel resistance in human breast cancer cell line MCF-7/R by promoting cell apoptosis.
PMID: 31068300 [PubMed - in process]
Source: Journal of Southern Medical University - March 29, 2019 Category: Universities & Medical Training Authors: Tian N, Zhou L, Yang D, Wu H, Ma Y, Lü L, Wu S Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research
Cbl-b gene silencing enhances H9 T lymphocyte-mediated killing of human laryngeal squamous cancer Hep-2 cells.
CONCLUSIONS: Cbl-b gene silencing effectively enhances the killing effect of H9 T lymphocytes against Hep-2 cells in vitro probably as the result of enhanced IL-2 secretion and T lymphocyte activation.
PMID: 31140419 [PubMed - in process]
Source: Journal of Southern Medical University - May 29, 2019 Category: Universities & Medical Training Authors: Chen S, Li Z, Zhou L, Zhang Y Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research
Role of ZHX2 in regulating dorsal root ganglion μ-opioid receptor expression in mice with peripheral nerve injuryinduced pain hypersensitivity.
CONCLUSIONS: ZHX2 knockdown in the DRG reverses CCI-induced down-regulation of μ opioid receptor to alleviate periphery nerve injury-induced pain hypersensitivity in mice.
PMID: 31511211 [PubMed - in process]
Source: Journal of Southern Medical University - August 29, 2019 Category: Universities & Medical Training Authors: Sheng H, Mo K Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research
Small interfering RNA-mediated COX-2 gene silencing enhances chemosensitivity of KB/VCR cells by suppressing MDR-1 gene expression and P-glycoprotein activity.
CONCLUSION: COX-2 gene silencing can enhance the chemosensitivity of KB/VCR cells to vincristine, the mechanism of which may involve down-regulated MDR-1 gene expression and inhibition of P-glycoprotein activity.
PMID: 24849444 [PubMed - in process]
Source: Journal of Southern Medical University - May 20, 2014 Category: Universities & Medical Training Authors: Mo XC, Li WZ Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research
Cellular response to altered autophagy activity in human fibroblast cells overexpressing Ha-RasV12.
CONCLUSION: Stable cellular overexpression of oncogenic Ras causes tightly controlled suppression of the autophagic activity of human fibroblast cells, and such changes produce significant effect on cell senescence and survival.
PMID: 25413053 [PubMed - in process]
Source: Journal of Southern Medical University - November 20, 2014 Category: Universities & Medical Training Authors: Wang L, Yu L, Gu CP, Li YL Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research
miR-181c inhibits glycolysis by targeting hexokinase 2 in cancer-associated fibroblasts.
CONCLUSION: Transfection with miR-181 mimics can suppress glycolysis in CAFs by inhibiting HK2 expression.
PMID: 26607087 [PubMed - as supplied by publisher]
Source: Journal of Southern Medical University - November 20, 2015 Category: Universities & Medical Training Authors: Lan HB, Luo L, Qi XF, Gong YQ, Chen Y Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research
MicroRNA-199a-3p enhances expressions of fibrosis-associated genes through targeting Smad1 in mouse cardiac fibroblasts.
CONCLUSIONS: As the target gene of miR-199a-3p, Smad1 mediates the pro-fibrotic effect of miR-199a-3p by activating the Smad3 signaling in cultured mouse cardiac fibroblasts.
PMID: 30377137 [PubMed - in process]
Source: Journal of Southern Medical University - September 30, 2018 Category: Universities & Medical Training Authors: Liang J, Zhu W, Zhang Z, Zhu J, Fu Y, Lin Q, Kuang S, Zhang M, Shan Z Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research
Knocking down fascin inhibits cervical cancer cell proliferation and tumorigenesis in nude mice.
CONCLUSIONS: Knocking down fascin can inhibit the growth and tumorigenicity of cervical cancer cells in nude mice.
PMID: 30613006 [PubMed - in process]
Source: Journal of Southern Medical University - December 30, 2018 Category: Universities & Medical Training Authors: Li X, Li S, Wang X, Zhao S, Liu H Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research
