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Source: Journal of Southern Medical University
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Total 774 results found since Jan 2013.
CEP55 may be a potential therapeutic target for non-obstructive azoospermia with maturation arrest.
CONCLUSIONS: CEP55 may play a key role in spermatogenesis and may serve as a potential therapeutic target for non-obstructive azoospermia with maturation arrest.
PMID: 31640955 [PubMed - in process]
Source: Journal of Southern Medical University - September 29, 2019 Category: Universities & Medical Training Authors: Zhu Y, Liu J, Zhang W, Wu J, Li W, Li H, Chu Q, Luo C Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research
Effects of Sam68 gene silencing on proliferation of nasopharyngeal carcinoma cell line 5-8F and its possible molecular mechanism.
Abstract
OBJECTIVE: To observe the effect of Sam68 gene silencing on proliferation of nasopharyngeal carcinoma (NPC) cell line 5-8F and explore its possible molecular mechanism.
METHODS: The NPC cell line 5-8F was transfected with a small interfering RNA (siRNA) targeting Sam68 and the cell proliferation changes were observed. Quantitative RT-PCR and Western blotting were used to examine the changes in the expressions of Sam68, cell cycle-related proteins, and some up-stream proteins in the transfected cells.
RESULTS: Transfection of 5-8F cells with Sam68-specific siRNA significantly lowered the mRNA and...
Source: Journal of Southern Medical University - February 1, 2013 Category: Universities & Medical Training Authors: Yang B, Feng DH Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research
Strontium ranelate promotes osteogenic differentiation of rat bone mesenchymal stem cells through bone morphogenetic protein-2/Smad signaling pathway.
CONCLUSION: The BMP-2/Smad pathway is involved in Sr-induced osteoblast differentiation of rat BMSCs.
PMID: 23529235 [PubMed - in process]
Source: Journal of Southern Medical University - March 1, 2013 Category: Universities & Medical Training Authors: Lv H, Huang X, Jin S, Guo R, Wu W Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research
Functional role of protein kinase D1 in Aspergillums fumigates-induced activation of nuclear factor-κB signal pathway and transcription.
CONCLUSION: PKD1 may contribute to the activation of NF-κB signal pathway and NF-κB transcription induced by Aspergillums fumigates.
PMID: 23529230 [PubMed - in process]
Source: Journal of Southern Medical University - March 1, 2013 Category: Universities & Medical Training Authors: Niu X, Xu W, Li S, Ke Z, Zeng F, Luo S, Deng F Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research
Effects of stable ANO1 overexpression on biological behaviors of human laryngeal squamous cell carcinoma Hep-2 cells in vitro.
CONCLUSION: ANO1 overexpression does not significantly affect the proliferation of cancer cells, but can enhance the migration ability of head and neck squamous cell carcinoma, suggesting the value of ANO1 as a new gene therapy target for head and neck squamous cell carcinoma.
PMID: 24589607 [PubMed - in process]
Source: Journal of Southern Medical University - February 20, 2014 Category: Universities & Medical Training Authors: Li YD, Zhang JS, Yang K, Zhang FJ, Chen R, Chen D Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research
Effect of silencing Bmi-1 expression in reversing cisplatin resistance in lung cancer cells and its mechanism.
CONCLUSION: Silencing Bmi-1 by RNA interference can induce cell senescence and resensitize A549/DDP cells to cisplatin possibly by regulating INK4a/ARF/Rb senescence pathway.
PMID: 25057072 [PubMed - in process]
Source: Journal of Southern Medical University - July 20, 2014 Category: Universities & Medical Training Authors: Mao N, He GS, Rao JJ, Lv L Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research
Effect of RbAp48 knockdown on migration and invasion of human cervical cancer cell line MS751 in vitro.
CONCLUSION: Knockdown of RbAp48 can significantly inhibit epithelial-mesenchymal transition and suppress the migration and invasion of cervical cancer cell line MS751, the mechanism of which may involve the down-regulation of Snail and Twist expressions.
PMID: 26607076 [PubMed - as supplied by publisher]
Source: Journal of Southern Medical University - November 20, 2015 Category: Universities & Medical Training Authors: Zhong JJ, Yang XR, Mai MQ, Wang DD, Lv L, Rao JJ Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research
Effect of HMGB1 on proliferation of human nasopharyngeal carcinoma cell line C666-1 in vitro.
CONCLUSION: HMGB1 can promote the proliferation of human nasopharyngeal carcinoma cell line C666-1 by up- regulating cyclin D1 and CDK6 via the STAT3 signaling pathway.
PMID: 26607072 [PubMed - as supplied by publisher]
Source: Journal of Southern Medical University - November 20, 2015 Category: Universities & Medical Training Authors: Hua SN, Xiao LS, Wu DH Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research
Effect of stable DNA methyltransferase 3bknockdown on proliferation and apoptosis in bladder cancer cells in vitro.
CONCLUSION: Stable DNMT3b knockdown can affect the methylation of the cell growth and apoptosis related genes to regulate their expression, which might be a possible mechanism for suppressed cell growth and enhanced apoptosis of BIU-87 cells.
PMID: 26607069 [PubMed - as supplied by publisher]
Source: Journal of Southern Medical University - November 20, 2015 Category: Universities & Medical Training Authors: Chen K, Li BK, Xu K, Xu AB, Liu CX, Zheng SB, Xu YW, Jia CY, Liu Q, Li HL Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research
Role of nuclear factor of activated T cells-2 in high mobility protein box-1 release in human monocytic THP-1 cells in vitro.
CONCLUSION: NFAT2 can inhibit HMGB1 release from THP-1 cells in vitro.
PMID: 26806731 [PubMed - in process]
Source: Journal of Southern Medical University - January 20, 2016 Category: Universities & Medical Training Authors: Zhao Q, Wang L, Hu J, Liu H Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research
Expressions of survivin, PI3K and AKT in keratinocytes in skin lesions and their pathogenic role in psoriasis vulgaris.
CONCLUSION: Survivin and PI3K/AKT signaling pathway may participate in the occurrence and progression of PV.
PMID: 29180333 [PubMed - in process]
Source: Journal of Southern Medical University - November 20, 2017 Category: Universities & Medical Training Authors: Wang H, Ran LW, Hui K, Wang XY, Zheng Y Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research
Quercetin attenuates Ox-LDL-induced calcification in vascular smooth muscle cells by regulating ROS-TLR4 signaling pathway.
CONCLUSIONS: Quercetin inhibits Ox-LDL-induced VSMC calcification in VSMCs possibly by targeting the ROS/TLR4 signaling pathway.
PMID: 30187880 [PubMed - in process]
Source: Journal of Southern Medical University - July 30, 2018 Category: Universities & Medical Training Authors: Liang Q, Chen Y, Li C, Lu L Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research
MTBP regulates migration and invasion of prostate cancer cells in vitro.
CONCLUSIONS: MTBP overexpression promotes the migration and invasion of human prostate cancer cells possibly relation to the induction of EMT.
PMID: 30692060 [PubMed - in process]
Source: Journal of Southern Medical University - January 30, 2019 Category: Universities & Medical Training Authors: Xiao Z, Chen M, Yang J, Yang C, Lü X, Tian H, Liu C Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research
Effect of telmisartan on expression of metadherin in the kidney of mice with unilateral ureter obstruction.
CONCLUSIONS: Telmisartan can suppress the production of extracellular matrix proteins and the expression of metadhein to attenuate UUO-induced renal fibrosis in mice.
PMID: 30890502 [PubMed - in process]
Source: Journal of Southern Medical University - March 1, 2019 Category: Universities & Medical Training Authors: Peng F, Li H, Yin B, Wang Y, Chen Y, Xu Z, Luo C, Long H Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research
YAP1 knockdown suppresses the proliferation, migration and invasion of human nasopharyngeal carcinoma cells.
CONCLUSIONS: YAP1 knockdown via siRNA suppresses the proliferation, migration and invasion of NPC cells in vitro, suggesting that YAP1 may serve as a therapeutic target for NPC.
PMID: 31068306 [PubMed - in process]
Source: Journal of Southern Medical University - March 29, 2019 Category: Universities & Medical Training Authors: Zhou Y, Yang R, Ma G Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research
