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Source: Toxicology and Applied Pharmacology
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Total 118 results found since Jan 2013.
The exosome-circ_0001359 derived from cigarette smoke exposed-prostate stromal cells promotes epithelial cells collagen deposition and primary ciliogenesis
In this study, human prostate epithelial RWPE-1 cells were co-cultured with exosomes derived from CS exposed-WPMY-1 cells (CS-WPMY-1-exo). The collagen deposition, primary ciliogenesis, epithelial-mesenchymal transition (EMT) and transforming growth factor (TGF)-β1 level of RWPE-1 were evaluated. The circRNAs profiles of WPMY-1-exo were explored by high-throughput RNA sequencing. It was found that CS-WPMY-1-exo significantly promoted RWPE-1 collagen deposition, EMT and primary ciliogenesis. There were 17 differentially expressed (DE) circRNAs (including circ_0001359) between CS-WPMY-1-exo and the negative control. Functio...
Source: Toxicology and Applied Pharmacology - December 30, 2021 Category: Toxicology Authors: Jinglou Chen Nan Rong Min Liu Congyue Xu Jing Guo Source Type: research
Melatonin alleviates doxorubicin-induced mitochondrial oxidative damage and ferroptosis in cardiomyocytes by regulating YAP expression
In this study, we established a Dox-induced cardiotoxicity model in H9c2 cardiomyocytes, zebrafish, and SD rats to explore the mechanism by which Mel alleviates Dox-induced cardiotoxicity. In vivo and in vitro experiments showed that Dox significantly decreased the viability of H9c2 cells, induced apoptosis, myocardial injury, and effectively up-regulated the expression of p-YAP but down-regulated the expression of YAP. Furthermore, we found that Dox significantly up-regulated the expression of ferroptosis-associated protein ACSL4 and down-regulated expression of GPX4. Interestingly, these effects of Dox were reversed foll...
Source: Toxicology and Applied Pharmacology - January 30, 2022 Category: Toxicology Authors: Xiao Sun Ping Sun Dong Zhen Xiangli Xu Li Yang Danni Fu Chengxi Wei Xiaofeng Niu Jiawei Tian Hairu Li Source Type: research
Cadmium induces placental glucocorticoid barrier damage by suppressing the cAMP/PKA/Sp1 pathway and the protective role of taurine
Toxicol Appl Pharmacol. 2022 Feb 24:115938. doi: 10.1016/j.taap.2022.115938. Online ahead of print.ABSTRACTCadmium (Cd) exposure during pregnancy damages the placental glucocorticoid (GC) barrier, exposes the foetus to excess corticosterone (CORT) levels, and eventually inhibits foetal development. In addition, taurine (Tau) alleviates the toxicity of Cd on liver and kidney, but limited data are available on the role of Tau against the toxicity of heavy metals on female reproduction and fetal development. The present study was conducted to investigate the specific mechanism of Cd-induced placental GC barrier damage and the...
Source: Toxicology and Applied Pharmacology - February 27, 2022 Category: Toxicology Authors: Na Chen Xia Tong Sisi Wu Xu Xu Qihui Chen Fan Wang Source Type: research
Hexavalent chromium increases the metabolism and genotoxicity of aromatic amine carcinogens 4-aminobiphenyl and β-naphthylamine in immortalized human lung epithelial cells
The objective of the research presented here is to investigate the effects of Cr(VI) on the metabolism and genotoxicity of 4-ABP and BNA in immortalized human lung epithelial cells (BEP2D) expressing NAT1 and NAT2. Exposure to Cr(VI) for 48 h increased NAT1 activity (linear regression analysis: P < 0.0001) as measured by N-acetylation of para-aminobenzoic acid (PABA) in BEP2D cells but not NAT2 N-acetylation of sulfamethazine, which are prototypic NAT1 and NAT2 substrates respectively. Cr(VI) also increased the N-acetylation of 4-ABP and BNA. In BEP2D cells the N-acetylation of 4-ABP (1-3 μM) exhibited a dose-dependent...
Source: Toxicology and Applied Pharmacology - June 6, 2022 Category: Toxicology Authors: James T F Wise Ra úl A Salazar-González Kennedy M Walls Mark A Doll Mariam R Habil David W Hein Source Type: research
Ring finger protein 10 improves pirarubicin-induced cardiac inflammation by regulating the AP-1/Meox2 signaling pathway
Toxicol Appl Pharmacol. 2023 Feb 3:116411. doi: 10.1016/j.taap.2023.116411. Online ahead of print.ABSTRACTOBJECTIVES: Pirarubicin (THP) is widely used in clinical antitumor therapy, but its cardiotoxicity seriously affects the therapeutic effect in patients. In the study, we investigated the role of ring finger protein 10 (RNF10) in cardiotoxicity induced by THP.MATERIALS AND METHODS: A cardiac toxicity model in Sprague-Dawley (SD) rats induced by THP was established. Changes in diet, weight, electrocardiogram (ECG), and echocardiography were observed. Serum levels of brain natriuretic peptide (BNP), creatine kinase MB (CK...
Source: Toxicology and Applied Pharmacology - February 5, 2023 Category: Toxicology Authors: Liang Duan Heng Tang Ying Lan Hongwei Shi Peng Pu Quan He Source Type: research
Suppression of SIRT1/FXR signaling pathway contributes to oleanolic acid-induced liver injury
In conclusion, our study reveals that SIRT1/FXR pathway is crucial in OA-induced hepatotoxicity. Activation of SIRT1/HNF1α/FXR axis may represent a novel therapeutic target for ameliorating OA and other herb-induced hepatotoxicity.PMID:37028458 | DOI:10.1016/j.taap.2023.116509
Source: Toxicology and Applied Pharmacology - April 7, 2023 Category: Toxicology Authors: Songjie Liao Xiaolong Fu Jianxiang Huang Yi Wang Yuanfu Lu Shaoyu Zhou Source Type: research
