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Source: Toxicology and Applied Pharmacology
Infectious Disease: HIV AIDS
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Total 1 results found since Jan 2013.
Celastrol ameliorates HIV-1 Tat-induced inflammatory responses via NF-kappaB and AP-1 inhibition and heme oxygenase-1 induction in astrocytes.
In this study, we investigated the modulatory effects of celastrol on HIV-1 Tat-induced inflammatory responses and the molecular mechanisms underlying its action in astrocytes. Pre-treatment of CRT-MG human astroglioma cells with celastrol significantly inhibited HIV-1 Tat-induced expression of ICAM-1/VCAM-1 and subsequent monocyte adhesiveness in CRT-MG cells. In addition, celastrol suppressed HIV-1 Tat-induced expression of pro-inflammatory chemokines, such as CXCL10, IL-8, and MCP-1. Celastrol decreased HIV-1 Tat-induced activation of JNK MAPK, AP-1, and NF-κB. Furthermore, celastrol induced mRNA and protein expression...
Source: Toxicology and Applied Pharmacology - July 23, 2014 Category: Toxicology Authors: Youn GS, Kwon DJ, Ju SM, Rhim H, Bae YS, Choi SY, Park J Tags: Toxicol Appl Pharmacol Source Type: research
