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Glycyrrhizic Acid Protects Glomerular Podocytes Induced by High Glucose by Modulating SNARK/AMPK Signaling Pathway
ConclusionGA can protect podocytes and alleviate fibrosis and inflammation induced by high glucose, which is related to the AMPK signaling pathway. Meanwhile, knockdown of SNARK protein can inhibit the AMPK signaling pathway, aggravate fibrosis, and increase inflammation.
Source: Journal of Huazhong University of Science and Technology -- Medical Sciences -- - July 14, 2023 Category: Research Source Type: research

DLAT as a Cuproptosis Promoter and a Molecular Target of Elesclomol in Hepatocellular Carcinoma
ConclusionCuproptosis and DLAT as a promising biomarker could help to determine the prognosis of HCC and may offer novel insights for effective treatment.
Source: Journal of Huazhong University of Science and Technology -- Medical Sciences -- - June 8, 2023 Category: Research Source Type: research

Calcitriol Suppressed Isoproterenol-induced Proliferation of Cardiac Fibroblasts via Integrin β3/FAK/Akt Pathway
ConclusionThese findings revealed a novel role for CAL in suppressing the CFs growth by the downregulation of the integrin β3/FAK/Akt pathway.
Source: Journal of Huazhong University of Science and Technology -- Medical Sciences -- - January 21, 2023 Category: Research Source Type: research

Endoplasmic Reticulum Stress-induced Endothelial Dysfunction Promotes Neointima Formation after Arteriovenous Grafts in Mice on High-fat Diet
ConclusionInhibiting ERS in ECs could improve the function of AVGs.
Source: Journal of Huazhong University of Science and Technology -- Medical Sciences -- - January 14, 2023 Category: Research Source Type: research

CYP24A1 Involvement in Inflammatory Factor Regulation Occurs via the Wnt Signaling Pathway
ConclusionTaken together, this study suggests that inflammatory factors may increase CYP24A1 expressionvia NF- κB pathway activation, which in turn stimulates Wnt signaling.
Source: Journal of Huazhong University of Science and Technology -- Medical Sciences -- - October 17, 2022 Category: Research Source Type: research

Inhibition of Ubiquitin-specific Protease 4 Attenuates Epithelial —Mesenchymal Transition of Renal Tubular Epithelial Cells via Transforming Growth Factor Beta Receptor Type I
ConclusionUSP4 promotes the EMT of RTECs through upregulating T βRI, thereby facilitating renal interstitial fibrosis. These findings may provide a potential target of USP4 in the treatment of renal fibrosis.
Source: Journal of Huazhong University of Science and Technology -- Medical Sciences -- - September 30, 2022 Category: Research Source Type: research

Lentivirus-Mediated Short Hairpin RNA for Follistatin Downregulation Suppresses Tumor Progression in Hypopharyngeal Carcinoma
ConclusionsOur results indicated that the FST gene was associated with HPC progression and may serve as a potential therapeutic target for the treatment of HPC.
Source: Journal of Huazhong University of Science and Technology -- Medical Sciences -- - July 21, 2022 Category: Research Source Type: research

FMR1NB Involved in Glioma Tumorigenesis Is a Promising Target for Prognosis and Therapy
ConclusionOur findings suggest that FMR1NB contributes to the tumorigenesis of glioma cells and may represent a potential prognostic biomarker and an attractive therapeutic target in glioma.
Source: Journal of Huazhong University of Science and Technology -- Medical Sciences -- - July 11, 2022 Category: Research Source Type: research

Hypoxia Inhibits Proliferation of Human Dermal Lymphatic Endothelial Cells via Downregulation of Carcinoembryonic Antigen-related Cell Adhesion Molecule 1 Expression
ConclusionOur results suggested that hypoxia downregulates CEACAM1 expression by activation of the JNK pathway, leading to inhibition of HDLEC proliferation. These findings may help to understand the mechanisms of LEC-specific response to hypoxia and develop novel therapies for pathological lymphangiogenesis.
Source: Journal of Huazhong University of Science and Technology -- Medical Sciences -- - November 30, 2021 Category: Research Source Type: research

BOP1 Silencing Suppresses Gastric Cancer Proliferation through p53 Modulation
This study aimed to explore the expression of BOP1 in GC and its potential mechanisms in regulating GC growth, and the relationship between BOP1 level in cancer tissues and survival was also analyzed. The expression of BOP1 was examined by immunohistochemistry (IHC) in a cohort containing 387 patients with primary GC. Cultured GC cells were treated by siRNA to knock down the BOP1 expression, and examined by CCK-8 assay and plate clone formation to assess cell proliferationin vitro. Apoptotic rate of cultured GC cells was detected by flow cytometry with double staining of AnnxinV/PI. The xenografted mouse model was used to ...
Source: Journal of Huazhong University of Science and Technology -- Medical Sciences -- - April 1, 2021 Category: Research Source Type: research

Involvement of TRPC1 and Cyclin D1 in Human Pulmonary Artery Smooth Muscle Cells Proliferation Induced by Cigarette Smoke Extract
SummaryCigarette smoking contributes to the development of pulmonary artery hypertension (PAH). As the basic pathological change of PAH, pulmonary vascular remodeling is considered to be related to the abnormal proliferation of pulmonary artery smooth muscle cells (PASMCs). However, the molecular mechanism underlying this process remains not exactly clear. The aim of this research was to study the molecular mechanism of PASMCs proliferation induced by smoking. Human PASMCs (HPASMCs) were divided into 6 groups: 0% (control group), cigarette smoking extract (CSE)-treated groups at concentrations of 0.5%, 1%, 2%, 5%, 10% CSE ...
Source: Journal of Huazhong University of Science and Technology -- Medical Sciences -- - December 1, 2020 Category: Research Source Type: research

A β40 Promotes the Osteoblastic Differentiation of Aortic Valve Interstitial Cells through the RAGE Pathway
SummaryAmyloid beta (A β) peptide 40 enhances the activation of receptor for advanced glycation end products (RAGE) in immune-inflammatory diseases. RAGE exhibits several effects in the setting of numerous cardiovascular events. We hypothesized that the Aβ40/RAGE pathway is involved in the osteoblastic differentiation o f the valvular interstitial cell (VIC) phenotype, and RAGE knockout intervention could reduce the calcification of aortic valve interstitial cells (AVICs) by inhibiting the extracellular-regulated kinase1/2 (ERK1/2)/nuclear factor kappa-B (NF-κB) signaling pathway. To test this hypothesis, the acti vatio...
Source: Journal of Huazhong University of Science and Technology -- Medical Sciences -- - October 1, 2020 Category: Research Source Type: research

Curcumin Recovers Intracellular Lipid Droplet Formation Through Increasing Perilipin 5 Gene Expression in Activated Hepatic Stellate Cells In Vitro
This study aims at evaluating the effect of curcumin on lipid accumulation in HSCs and hepatocytes, and further elucidating the underlying mechanisms. Now we showed that curcumin increased LD formation in activated HSCs and stimulated the expression of sterol regulatory element-binding protein and fatty acid synthase, and reduced the expression of adipose triglyceride lipase. Exogenous perilin5 expression in primary HSCs promoted LD formation. Perilipin 5 siRNA eliminated curcumin-induced LD formation in HSCs. The se results suggest that curcumin recovers LD formation and lipid accumulation in activated HSCs by increasing ...
Source: Journal of Huazhong University of Science and Technology -- Medical Sciences -- - September 30, 2019 Category: Research Source Type: research

Lactate Promotes Cancer Stem-like Property of Oral Sequamous Cell Carcinoma
SummaryAccumulation of lactate in tumor has been linked to poor prognosis of oral squamous cell carcinoma (OSCC), but the underlying mechanism remained largely uncertain. Previous studies have suggested that presence of cancer stem cells (CSCs) closely correlated with cellular malignancy of OSCC. Here, using 3D organoid culture model, we investigated whether lactate promoted CSCs phenotype in primary OSCC cells. We generated organoids using fresh OSCC specimens and verified that organoids recapitulated histopathology and cellular heterogeneity of parental tumor. Organoids were then transfected with a Wnt reporter to visual...
Source: Journal of Huazhong University of Science and Technology -- Medical Sciences -- - May 31, 2019 Category: Research Source Type: research

Decrease of GSK3 β Ser-9 Phosphorylation Induced Osteoblast Apoptosis in Rat Osteoarthritis Model
AbstractNowadays, the cumulative intake of glucocorticoids has become the most common pathogenic factor for non-traumatic osteonecrosis of the femoral head (ONFH). Apoptosis of osteoblasts is considered as the main reason of ONFH at the molecular level. Glycogen synthase kinase 3 β (GSK3β) is an important regulator of cellular differentiation and apoptosis pathway, which can modulate the balance between osteoblasts and osteoclasts. Several studies have reported about its function in osteoporosis, but little is known about it in osteonecrosis. In our study, lipopolysacchari de and methylprednisolone were utilized to estab...
Source: Journal of Huazhong University of Science and Technology -- Medical Sciences -- - January 31, 2019 Category: Research Source Type: research

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