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Knockdown of Dnmt1 and Dnmt3a gene expression disrupts preimplantation embryo development through global DNA methylation
ConclusionPrecisely aligned expression of Dnmt genes is highly essential for the fate of an embryo in the early developmental period. Our data indicates that further analysis is mandatory to designate the specific targets of these methylation/demethylation processes in mouse and human preimplantation embryos.
Source: Journal of Assisted Reproduction and Genetics - September 17, 2021 Category: Reproduction Medicine Source Type: research

FoxO transcription factors 1 regulate mouse preimplantation embryo development
ConclusionsThese results suggest that FOXO transcription factors could contribute to mouse preimplantation embryo development, and it remains to investigate whether they have crucial roles in human preimplantation embryo and infertility.
Source: Journal of Assisted Reproduction and Genetics - August 7, 2019 Category: Reproduction Medicine Source Type: research

Maternally contributed Nlrp9b expressed in human and mouse ovarian follicles contributes to early murine preimplantation development
ConclusionsThese results suggest that mouseNlrp9b, as a maternal effect gene, could contribute to mouse preimplantation embryo development. It remains to investigate whether NLRP9 have a crucial role in human preimplantation embryo and infertility.
Source: Journal of Assisted Reproduction and Genetics - May 11, 2020 Category: Reproduction Medicine Source Type: research

Supplementing culture medium with the weak acid, 5,5-dimethyl-2,4-oxazolidinedione (DMO) limits the development  of aneuploid mouse embryos through a Trp53-dependent mechanism
ConclusionThese studies suggest that the development of morphologically normal aneuploid-enriched mouse blastocysts can be inhibited by adding low amounts of DMO to the culture media, which results in elevated levels ofTrp53 mRNA that suppressesOct-4 andCdx2 expression.
Source: Journal of Assisted Reproduction and Genetics - April 14, 2023 Category: Reproduction Medicine Source Type: research

Downregulation of gene expression and activity of GRIM-19 affects mouse oocyte viability, maturation, embryo development and implantation
Conclusions GRIM-19 may play important roles in mouse oogenesis and early embryonic development and implantation.
Source: Journal of Assisted Reproduction and Genetics - January 6, 2015 Category: Reproduction Medicine Source Type: research

Embryonic MTHFR contributes to blastocyst development
ConclusionThe results indicate that embryonic MTHFR is indispensable for normal blastocyst development. The findings provide insight into the debatable roles of MTHFR in fertility and may be applicable for the improvement of care for early embryos via modulation of surrounding folate-related nutritional conditions in vitro and/or in utero, depending on the parental and embryonicMTHFR genotype.
Source: Journal of Assisted Reproduction and Genetics - August 6, 2020 Category: Reproduction Medicine Source Type: research

The function of Nucleoporin 37 on mouse oocyte maturation and preimplantation embryo development
ConclusionsIn summary, NUP37 played an important role in mice oocyte maturation and preimplantation embryo development.
Source: Journal of Assisted Reproduction and Genetics - January 13, 2022 Category: Reproduction Medicine Source Type: research

Suppression of FPR2 expression inhibits inflammation in preeclampsia by improving the biological functions of trophoblast via NF- κB pathway
ConclusionSuppression of FPR2 expression alleviated the effects of inflammation induced by LPS on trophoblasts via the NF- κB signaling pathway, which provided a novel and potential strategy for the treatment of PE.
Source: Journal of Assisted Reproduction and Genetics - January 11, 2022 Category: Reproduction Medicine Source Type: research

Downregulated INHBB in endometrial tissue of recurrent implantation failure patients impeded decidualization through the ADCY1/cAMP signalling pathway
ConclusionsThe decline of INHBB in HESCs suppressed ADCY1-induced cAMP production and cAMP-mediated signalling, which attenuated decidualization in RIF patients, indicating that INHBB is an essential component in the decidualization process.
Source: Journal of Assisted Reproduction and Genetics - March 13, 2023 Category: Reproduction Medicine Source Type: research

Effect of peroxiredoxin 1 on the regulation of trophoblast function by affecting autophagy and oxidative stress in preeclampsia
ConclusionPRDX1 regulated trophoblast function through the PTEN/AKT signaling pathway to affect cell autophagy and ROS level, which provided a potential target for the treatment of PE.
Source: Journal of Assisted Reproduction and Genetics - May 25, 2023 Category: Reproduction Medicine Source Type: research