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Vector derived artificial miRNA mediated inhibition of West Nile virus replication and protein expression.
Abstract West Nile virus (WNV) has been found to be a common cause of neuroinvasive arboviral disease worldwide in human and horses. The process of RNA interference induced by small RNA molecules, like small interfering RNA (siRNA) and microRNA (miRNA), proved to be a novel approach for preventing viral infections. So far there is no published data for inhibition of West Nile virus by vector delivered artificial miRNA which believed to have more inhibitory potential than small interfering (siRNA). In the present study, we designed two artificial miRNA (amiRNAs) targeting the conserved NS5 and NS2A genomic regions ...
Source: Gene - December 25, 2019 Category: Genetics & Stem Cells Authors: Karothia D, Kumar Dash P, Parida M, Bhagyawant SS, S Kumar J Tags: Gene Source Type: research