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Source: Ecotoxicology and Environmental Safety
Nutrition: Antidoxidants
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Total 709 results found since Jan 2013.
Melatonin or vitamin C attenuates lead acetate-induced testicular oxidative and inflammatory damage in mice by inhibiting oxidative stress mediated NF- κB signaling
In this study, we aimed to determine the effects of lead acetate on reproductive function in male mice, identify the underlying mechanisms, and test counter measures to alleviate the toxic effects. Male mice were dosed with lead acetate (500 mg/L) in free drinking water for 12 weeks, and administered melatonin (5 mg/kg) or vitamin C (500 mg/kg) by intraperitoneal injection. Blood from the eyeball, testicles, and sperm from the caudal epididymis were collected after 12 weeks and analyzed. Pb exposure reduced sperm count and motility, increased sperm malformation (P < 0.01), disrupted testicular morphology and structure, ...
Source: Ecotoxicology and Environmental Safety - September 16, 2023 Category: Environmental Health Authors: Ze-Min Zhao Su Mei Qi-Yue Zheng Jiao Wang Yi-Ru Yin Jiao-Jiao Zhang Xian-Zhong Wang Source Type: research
Curcumin protects against fenvalerate-induced neurotoxicity in zebrafish (Danio rerio) larvae through inhibition of oxidative stress
This study aimed to explore the mechanisms underlying FEN-induced neurotoxicity using the zebrafish (Danio rerio) model. We also investigated whether curcumin (CUR), a polyphenol antioxidant that exhibits neuroprotective properties, can prevent FEN-induced neurotoxicity. Here, zebrafish embryos were exposed to 0, 3.5, 7 and 14 μg/L of FEN from 4 to 96 h post fertilization (hpf) and neurotoxicity was assessed. Our results showed that FEN decreased the survival rate, heart rate, body length and spontaneous movement, and increased malformation rate. FEN caused neurobehavioral alterations, including decreased swimming distanc...
Source: Ecotoxicology and Environmental Safety - September 16, 2023 Category: Environmental Health Authors: Jiansheng Zhu Mingtao Huang Chunlan Liu Jingyu Wang Li Zou Fan Yang Renfei Zhu Source Type: research
Melatonin or vitamin C attenuates lead acetate-induced testicular oxidative and inflammatory damage in mice by inhibiting oxidative stress mediated NF- κB signaling
In this study, we aimed to determine the effects of lead acetate on reproductive function in male mice, identify the underlying mechanisms, and test counter measures to alleviate the toxic effects. Male mice were dosed with lead acetate (500 mg/L) in free drinking water for 12 weeks, and administered melatonin (5 mg/kg) or vitamin C (500 mg/kg) by intraperitoneal injection. Blood from the eyeball, testicles, and sperm from the caudal epididymis were collected after 12 weeks and analyzed. Pb exposure reduced sperm count and motility, increased sperm malformation (P < 0.01), disrupted testicular morphology and structure, ...
Source: Ecotoxicology and Environmental Safety - September 16, 2023 Category: Environmental Health Authors: Ze-Min Zhao Su Mei Qi-Yue Zheng Jiao Wang Yi-Ru Yin Jiao-Jiao Zhang Xian-Zhong Wang Source Type: research
Curcumin protects against fenvalerate-induced neurotoxicity in zebrafish (Danio rerio) larvae through inhibition of oxidative stress
This study aimed to explore the mechanisms underlying FEN-induced neurotoxicity using the zebrafish (Danio rerio) model. We also investigated whether curcumin (CUR), a polyphenol antioxidant that exhibits neuroprotective properties, can prevent FEN-induced neurotoxicity. Here, zebrafish embryos were exposed to 0, 3.5, 7 and 14 μg/L of FEN from 4 to 96 h post fertilization (hpf) and neurotoxicity was assessed. Our results showed that FEN decreased the survival rate, heart rate, body length and spontaneous movement, and increased malformation rate. FEN caused neurobehavioral alterations, including decreased swimming distanc...
Source: Ecotoxicology and Environmental Safety - September 16, 2023 Category: Environmental Health Authors: Jiansheng Zhu Mingtao Huang Chunlan Liu Jingyu Wang Li Zou Fan Yang Renfei Zhu Source Type: research
Plant growth-promoting bacteria modulate gene expression and induce antioxidant tolerance to alleviate synergistic toxicity from combined microplastic and Cd pollution in sorghum
This study provides the first demonstration that plant growth-promoting bacteria can alleviate the stress caused by combined pollution with MPs and Cd by regulating plant gene expression. These findings provide a reference for the combined plant-microbial remediation of MPs and Cd.PMID:37690172 | DOI:10.1016/j.ecoenv.2023.115439
Source: Ecotoxicology and Environmental Safety - September 10, 2023 Category: Environmental Health Authors: Yong-Qi Liu Yan Chen Xue-Min Ren Yu-Ying Li Ying-Jun Zhang Hao Zhang Hui Han Zhao-Jin Chen Source Type: research
Probing the effects of silicon amendment on combined stressors on rice: Lead pollution and blast fungus (Magnaporthe oryzae) infection
Ecotoxicol Environ Saf. 2023 Sep 6;264:115443. doi: 10.1016/j.ecoenv.2023.115443. Online ahead of print.ABSTRACTAs agroecology deteriorates, agricultural production is threatened by the combined stressors of exposure to environmental pollutants and pathogenic microbes. Proper agronomic practices for crop growth management and fertilization require understanding plant tolerance strategies. Both rice blast and heavy metals substantially impair rice crops, while silicon (Si) is an effective amendment to alleviate the combined stressors. Herein, this study was conducted to investigate the rice physiology and pathology perspect...
Source: Ecotoxicology and Environmental Safety - September 8, 2023 Category: Environmental Health Authors: Bo Tan Yue Zeng Yihan Li Xiao Tan Chao Liu Longguo Li Wenhua Zhuang Zhuo Li Source Type: research
Dose dependent effect of nitrogen on the phyto extractability of Cd in metal contaminated soil using Wedelia trilobata
This study demonstrated that W. trilobata positively responds to Cd with enhanced growth and antioxidant capabilities, providing a new platform for phytoremediation in agricultural lands to protect the environment from heavy metals pollution.PMID:37651793 | DOI:10.1016/j.ecoenv.2023.115419
Source: Ecotoxicology and Environmental Safety - August 31, 2023 Category: Environmental Health Authors: Irfan Ullah Khan Yi-Fan Zhang Xin-Ning Shi Shan-Shan Qi Hai-Yan Zhang Dao-Lin Du Farrukh Gul Jia-Hao Wang Misbah Naz Syed Waqas Ali Shah Hui Jia Jian Li Zhi-Cong Dai Source Type: research
Comprehensive assessment of detoxification mechanisms of hydrolysis fish peptides in largemouth bass (Micropterus salmoides) under copper exposure: Tracing from bioaccumulation, oxidative stress, lipid deposition to metabolomics
In conclusion, our study confirmed that HFP supplementation was closely associated with oxidative stress, enzymatic activities and related pathways of lipid metabolism, and apoptosis, and in general alleviated lipid deposition caused by copper exposure in largemouth bass.PMID:37651792 | DOI:10.1016/j.ecoenv.2023.115418
Source: Ecotoxicology and Environmental Safety - August 31, 2023 Category: Environmental Health Authors: Di Wu Liansheng Wang Ze Fan Jinnan Li Shizhan Tang Chen Zhao Haitao Zhang Xianhu Zheng Source Type: research
Mitochondrial oxidative stress regulates LonP1-TDP-43 pathway and rises mitochondrial damage in carbon tetrachloride-induced liver fibrosis
Ecotoxicol Environ Saf. 2023 Aug 28;264:115409. doi: 10.1016/j.ecoenv.2023.115409. Online ahead of print.ABSTRACTCarbon tetrachloride (CCl4)-mediated liver damage has been well recognized, but the sources and mechanisms of mitochondrial damage during this progress still remain poorly understood. Accumulating evidence has revealed that LonP1-TDP-43 pathway affect proper mitochondrial integrity and function in neurodegenerative diseases. The current study aims to investigate whether mitochondrial oxidative stress regulate LonP1-TDP-43 pathway and the possible roles of this pathway in CCl4-driven liver fibrosis. We found that...
Source: Ecotoxicology and Environmental Safety - August 30, 2023 Category: Environmental Health Authors: Shulin Shan Zhidan Liu Shuai Wang Zhaoxiong Liu Shihua Chao Cuiqin Zhang Ming Li Fuyong Song Source Type: research
Effects of cadmium exposure on metabolism, antioxidant defense, immune function, and the hepatopancreas transcriptome of Cipangopaludina cathayensis
This study to investigate the toxic effects of Cd on the standard metabolism, antioxidant activities, immune function, and hepatopancreas transcriptome profiles of C. cathayensis. C. cathayensis was exposed to 0.25, 0.5, 1.0, or 1.5 mg/L Cd for 3 h, with results showing that Cd significantly inhibited oxygen consumption and ammonia excretion and disrupted the respiratory metabolism of C. cathayensis. In addition, the O:N ratio dropped below 7, indicating that C. cathayensis may rely exclusively on proteins as an energy source under Cd stress. To understand how Cd impacts the antioxidant activities, immune function, and tra...
Source: Ecotoxicology and Environmental Safety - August 30, 2023 Category: Environmental Health Authors: Y Y Wu W F Tian C X Cheng L Yang Q Q Ye W H Li J Y Jiang Source Type: research
Mitochondrial oxidative stress regulates LonP1-TDP-43 pathway and rises mitochondrial damage in carbon tetrachloride-induced liver fibrosis
Ecotoxicol Environ Saf. 2023 Aug 28;264:115409. doi: 10.1016/j.ecoenv.2023.115409. Online ahead of print.ABSTRACTCarbon tetrachloride (CCl4)-mediated liver damage has been well recognized, but the sources and mechanisms of mitochondrial damage during this progress still remain poorly understood. Accumulating evidence has revealed that LonP1-TDP-43 pathway affect proper mitochondrial integrity and function in neurodegenerative diseases. The current study aims to investigate whether mitochondrial oxidative stress regulate LonP1-TDP-43 pathway and the possible roles of this pathway in CCl4-driven liver fibrosis. We found that...
Source: Ecotoxicology and Environmental Safety - August 30, 2023 Category: Environmental Health Authors: Shulin Shan Zhidan Liu Shuai Wang Zhaoxiong Liu Shihua Chao Cuiqin Zhang Ming Li Fuyong Song Source Type: research
Effects of cadmium exposure on metabolism, antioxidant defense, immune function, and the hepatopancreas transcriptome of Cipangopaludina cathayensis
This study to investigate the toxic effects of Cd on the standard metabolism, antioxidant activities, immune function, and hepatopancreas transcriptome profiles of C. cathayensis. C. cathayensis was exposed to 0.25, 0.5, 1.0, or 1.5 mg/L Cd for 3 h, with results showing that Cd significantly inhibited oxygen consumption and ammonia excretion and disrupted the respiratory metabolism of C. cathayensis. In addition, the O:N ratio dropped below 7, indicating that C. cathayensis may rely exclusively on proteins as an energy source under Cd stress. To understand how Cd impacts the antioxidant activities, immune function, and tra...
Source: Ecotoxicology and Environmental Safety - August 30, 2023 Category: Environmental Health Authors: Y Y Wu W F Tian C X Cheng L Yang Q Q Ye W H Li J Y Jiang Source Type: research
Role of ROS-mediated PERK/ATF4 signaling activation in extracorporeal tube formation injury of human umbilical vein endothelial cells induced by cooking oil fume PM < sub > 2.5 < /sub > exposure
This study aimed to investigate the role of ROS-mediated PERK/ATF4 signaling activation in COF-PM2.5-inhibited extracorporeal tube formation in human umbilical vein endothelial cells (HUVECs). HUVECs were treated with 100 μg/mL COF-PM2.5 at different times, with or without 100 nM PERK activity inhibitor GSK2606414 (GSK) or 200 μM antioxidant N-acetylcysteine (NAC) pretreatment. Our results showed that COF-PM2.5 exposure can inhibit extracorporeal tube formation and down-regulate VEGFR2 expression in HUVECs. Furthermore, our data indicated that COF-PM2.5 exposure can activate the PERK/ATF4 signaling in HUVECs. Mechanistic...
Source: Ecotoxicology and Environmental Safety - August 23, 2023 Category: Environmental Health Authors: Shu Sun Chao Zhang Qi Zhang Changlian Li Dan Huang Rui Ding Jiyu Cao Jiahu Hao Source Type: research
