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Source: Virology
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Total 55 results found since Jan 2013.
Rat and human cytomegalovirus ORF116 encodes a virion envelope glycoprotein required for infectivity
Virology. 2021 Feb 9;557:23-33. doi: 10.1016/j.virol.2020.12.014. Online ahead of print.ABSTRACTHerpesviruses encode multiple glycoproteins required for different stages of viral attachment, fusion, and envelopment. The protein encoded by the human cytomegalovirus (HCMV) open reading frame UL116 forms a stable complex with glycoprotein H that is incorporated into virions. However, the function of this complex remains unknown. Herein, we characterize R116, the rat CMV (RCMV) putative homolog of UL116. Two R116 transcripts were identified in fibroblasts with three proteins expressed with molecular weights of 42, 58, and 82 k...
Source: Virology - February 18, 2021 Category: Virology Authors: Philippe Gatault Iris K A Jones Christine Meyer Craig Kreklywich Timothy Alexander Patricia P Smith Michael Denton Josh Powell Susan L Orloff Daniel N Streblow Source Type: research
Thymidylate synthase is essential for efficient HIV-1 replication in macrophages
Virology. 2021 Jun 14;561:47-57. doi: 10.1016/j.virol.2021.05.002. Online ahead of print.ABSTRACTThymidylate synthase (TS) is a key enzyme in nucleotide biosynthesis. A study performed by our group on human monocyte-derived macrophages (MDMs) infected with HIV-1 showed that many enzymes related to the folate cycle pathway, such as TS, are upregulated in productively infected cells. Here, we suggest that TS is essential for an effective HIV-1 infection in MDMs. Indeed, a TS specific small interfering RNA (siRNA) as well as the TS specific inhibitor Raltitrexed (RTX) caused a reduction in productively infected cells. Quantit...
Source: Virology - June 19, 2021 Category: Virology Authors: Vincent Desrosiers Corinne Barat Yann Breton Michel Ouellet Michel J Tremblay Source Type: research
siRNAs pools generated in Escherichia coli exhibit strong RNA-interference activity against influenza virus genomic sequences
Virology. 2022 Dec 31;579:38-45. doi: 10.1016/j.virol.2022.12.013. Online ahead of print.ABSTRACTDue to the recurrent pandemic outbreaks that occurred during the last century, Influenza A viruses are considered a serious potential danger to human health. Among the innate immune pathways in eukaryotes, RNA interference plays a significant role in the interaction between viruses and host cells. RNA interference is addressed by small dsRNA molecules produced by the host itself (miRNAs, i.e. "micro-RNAs") but can be triggered also by the administration of exogenous short RNAs (siRNAs, "short interfering RNAs"). In this work, a...
Source: Virology - January 4, 2023 Category: Virology Authors: Riccardo Villa Sabrina Renzi Silvia Dotti Franco Lucchini Source Type: research
Activation of p53-regulated pro-survival signals and hypoxia-independent mitochondrial targeting of TIGAR by human papillomavirus E6 oncoproteins
Virology. 2023 May 22;585:1-20. doi: 10.1016/j.virol.2023.05.004. Online ahead of print.ABSTRACTThe high-risk subtype human papillomaviruses (hrHPVs) infect and oncogenically transform basal epidermal stem cells associated with the development of squamous-cell epithelial cancers. The viral E6 oncoprotein destabilizes the p53 tumor suppressor, inhibits p53 K120-acetylation by the Tat-interacting protein of 60 kDa (TIP60, or Kat5), and prevents p53-dependent apoptosis. Intriguingly, the p53 gene is infrequently mutated in HPV + cervical cancer clinical isolates which suggests a possible paradoxical role for this gatekeeper i...
Source: Virology - May 31, 2023 Category: Virology Authors: Lacin Yapindi Tetiana Bowley Nick Kurtaneck Rachel L Bergeson Kylie James Jillian Wilbourne Carolyn K Harrod Brenda Y Hernandez Brooke M Emerling Courtney Yates Robert Harrod Source Type: research
Amino acids 1811-1960 of myosin heavy chain 9 is involved in murine gammaherpesvirus 68 infection
Virology. 2023 Jul 24;587:109849. doi: 10.1016/j.virol.2023.109849. Online ahead of print.ABSTRACTMyosin heavy chain 9 (MYH9) has been identified as a crucial factor in gammaherpesvirus infection. Murine gammaherpesvirus 68 (MHV-68) was used as an appropriate viral model for investigating gammaherpesviruses in vivo and developing antiviral treatments. However, the roles of MYH9 in MHV-68 infection have not been documented. In the study, the relationship between the expression of MYH9 and MHV-68 infection and MYH9 as the antiviral target were analyzed. The results revealed that MYH9 was enriched on the cell surface and co-l...
Source: Virology - July 29, 2023 Category: Virology Authors: Ximeng Han Jordan J Clark Parul Sharma Eleanor G Bentley Anja Kipar Mohammed Alsayer Xiaolei Ren Amy Robinson Sondus Alaidarous Yang Mu Yani Sun Julian A Hiscox En-Min Zhou James P Stewart Qin Zhao Source Type: research
