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Source: Cellular Signalling
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Total 230 results found since Jan 2013.
ZNF746 promotes M2 macrophage polarisation and favours tumour progression in breast cancer via the Jagged1/Notch pathway
In conclusion, this study uncovers the role of ZNF746 in promoting M2 macrophage polarisation and suggests that ZNF746 may be a promising therapeutic target for limiting BC progression.PMID:37730102 | DOI:10.1016/j.cellsig.2023.110892
Source: Cellular Signalling - September 20, 2023 Category: Cytology Authors: Lu Liu Wen-Yue Zhao Xin-Yu Zheng Source Type: research
Musashi-2 binds with Fbxo6 to induce Rnaset2 ubiquitination and chemokine signaling pathway during vascular smooth muscle cell phenotypic switch in atherosclerosis
CONCLUSION: Our findings demonstrated that MSI2 could bind with Fbxo6 to induce Rnaset2 ubiquitination and the activation of chemokine signaling pathway during VSMC phenotypic switch in AS.PMID:37633478 | DOI:10.1016/j.cellsig.2023.110869
Source: Cellular Signalling - August 26, 2023 Category: Cytology Authors: Tao Zhang Shusheng Wu Rongwei Xu Shuguang Zhang Minghai Wang Jie Li Source Type: research
miR-147b is an oncomiR acting synergistically with HIPK2 to promote pancreatic carcinogenesis
This study addressed this issue based on in silico prediction, in vitro experiments, and in vivo validation. The differentially expressed PCa-related miRNAs and bioinformatics tools predicted downstream regulators. The expression of miR-147b was examined in PCa cell lines. Putative targets of miR-147b were predicted by a publicly available database and confirmed by luciferase activity assay. Mimic/inhibitor, siRNA/overexpression plasmid, or pifithrin-α (p53 inhibitor) were delivered into PCa cells to assess the effect of miR-147b, HIPK2, and p53 on malignant phenotypes of PCa cells. AntagomiR-147b and shRNA targeting HIPK...
Source: Cellular Signalling - August 5, 2023 Category: Cytology Authors: Ganggang Wang Zenghui Ma Chao Song Xiaoliang Wang Zhijie Zhou Source Type: research
SGK1 is necessary to FoxO3a negative regulation, oxidative stress and cardiac fibroblast activation induced by TGF- β1
Cell Signal. 2023 Jun 19;109:110778. doi: 10.1016/j.cellsig.2023.110778. Online ahead of print.ABSTRACTCardiac fibroblasts (CFs) activation is a common response to most pathological conditions affecting the heart, characterized by increased cellular secretory capacity and increased expression of fibrotic markers, such as collagen I and smooth muscle actin type alpha (α-SMA). Fibrotic activation of CFs induces the increase in tissue protein content, with the consequent tissue stiffness, diastolic dysfunction, and heart failure. Therefore, the search for new mechanisms of CFs activation is important to find novel treatments...
Source: Cellular Signalling - June 21, 2023 Category: Cytology Authors: Fabiola Gonz ález-Herrera Mabel Catal án Renatto Anfossi Juan Diego Maya Zully Pedrozo Guillermo D íaz-Araya Ra úl Vivar Source Type: research
STING deletion alleviates podocyte injury through suppressing inflammation by targeting NLRP3 in diabetic kidney disease
This study evaluated the potential role of STING in high glucose (HG)-induced podocyte inflammation response. STING expression was significantly increased in db/db mice, STZ-treated diabetic mice, and HG-treated podocytes. Podocyte-specific deletion of STING alleviated podocyte injury, renal dysfunction, and inflammation in STZ-induced diabetic mice. STING inhibitor (H151) administration ameliorated inflammation and improved renal function in db/db mice. STING deletion in podocytes attenuated the activation of the NLRP3 inflammasome and podocyte pyroptosis in STZ-induced diabetic mice. In vitro, modulated STING expression ...
Source: Cellular Signalling - June 17, 2023 Category: Cytology Authors: Xueyan Yang Zhaowei Chen Zilv Luo Dingping Yang Yiqun Hao Jijia Hu Jun Feng Zijing Zhu Qiang Luo Zongwei Zhang Wei Liang Guohua Ding Source Type: research
Visfatin-induced upregulation of lipogenesis via EGFR/AKT/GSK3 β pathway promotes breast cancer cell growth
Cell Signal. 2023 Apr 19:110686. doi: 10.1016/j.cellsig.2023.110686. Online ahead of print.ABSTRACTBreast cancer (BC) incidence and associated mortality have increased in tandem with the growth in obesity among the females worldwide. An adipokine, visfatin, has been shown to potentially impact glucose, lipid, and protein metabolism, and promote cancer growth however, the mechanism underlying the effect of visfatin on lipid metabolism dysregulation contributing to BC cell survival, proliferation, and metastasis has not been elucidated. Herein, we have investigated the role of visfatin on the induction of Sterol regulatory e...
Source: Cellular Signalling - April 21, 2023 Category: Cytology Authors: Pradeep Kumar Rajput Johnna Francis Varghese Amit Kumar Srivastava Umesh Kumar Umesh C S Yadav Source Type: research
IL-1 β stimulates a novel, IKKα -dependent, NIK -independent activation of non-canonical NFκB signalling
In this study, we examined the activation of non-canonical nuclear factor Kappa B (NFκB) signalling in U2OS cells, a cellular metastatic bone cancer model. Whilst Lymphotoxin α1β2 (LTα1β2) stimulated the expected slow, delayed, sustained activation of serine 866/870 p100 phosphorylation and increased cellular expression of p52 NFκB, we found that canonical agonists, Interleukin-1β (IL-1β) and also Tumour necrosis factor-α (TNFα) generated a rapid transient increase in pp100, which was maximal by 15-30 min. This rapid phosphorylation was also observed in other cells types, such as DU145 and HCAECs suggesting the p...
Source: Cellular Signalling - April 20, 2023 Category: Cytology Authors: Kathryn McIntosh Yousif H Khalaf Rachel Craig Christopher West Ashley McCulloch Ajay Waghmare Christopher Lawson Edmond Y W Chan Simon Mackay Andrew Paul Robin Plevin Source Type: research
Visfatin-induced upregulation of lipogenesis via EGFR/AKT/GSK3 β pathway promotes breast cancer cell growth
Cell Signal. 2023 Apr 19:110686. doi: 10.1016/j.cellsig.2023.110686. Online ahead of print.ABSTRACTBreast cancer (BC) incidence and associated mortality have increased in tandem with the growth in obesity among the females worldwide. An adipokine, visfatin, has been shown to potentially impact glucose, lipid, and protein metabolism, and promote cancer growth however, the mechanism underlying the effect of visfatin on lipid metabolism dysregulation contributing to BC cell survival, proliferation, and metastasis has not been elucidated. Herein, we have investigated the role of visfatin on the induction of Sterol regulatory e...
Source: Cellular Signalling - April 19, 2023 Category: Cytology Authors: Pradeep Kumar Rajput Johnna Francis Varghese Amit Kumar Srivastava Umesh Kumar Umesh C S Yadav Source Type: research
IL-1 β stimulates a novel, IKKα -dependent, NIK -independent activation of non-canonical NFκB signalling
In this study, we examined the activation of non-canonical nuclear factor Kappa B (NFκB) signalling in U2OS cells, a cellular metastatic bone cancer model. Whilst Lymphotoxin α1β2 (LTα1β2) stimulated the expected slow, delayed, sustained activation of serine 866/870 p100 phosphorylation and increased cellular expression of p52 NFκB, we found that canonical agonists, Interleukin-1β (IL-1β) and also Tumour necrosis factor-α (TNFα) generated a rapid transient increase in pp100, which was maximal by 15-30 min. This rapid phosphorylation was also observed in other cells types, such as DU145 and HCAECs suggesting the p...
Source: Cellular Signalling - April 18, 2023 Category: Cytology Authors: Kathryn McIntosh Yousif H Khalaf Rachel Craig Christopher West Ashley McCulloch Ajay Waghmare Christopher Lawson Edmond Y W Chan Simon Mackay Andrew Paul Robin Plevin Source Type: research
