Filtered By:
Source: Brain, Behavior, and Immunity
This page shows you your search results in order of date.
Order by Relevance | Date
Total 25 results found since Jan 2013.
Adiponectin regulates electroacupuncture-produced analgesic effects in association with a crosstalk between the peripheral circulation and the spinal cord
In conclusion, the study indicates a novel mechanism that acupuncture produces analgesic effects at least partially via APN/AdipoR2-AMPK pathway in the spinal cord.PMID:34562596 | DOI:10.1016/j.bbi.2021.09.010
Source: Brain, Behavior, and Immunity - September 25, 2021 Category: Neurology Authors: Zhipeng Ning Pan Gu Jialing Zhang Chi Wai Cheung Lixing Lao Haiyong Chen Zhang-Jin Zhang Source Type: research
KDM6B epigenetically regulated-interleukin-6 expression in the dorsal root ganglia and spinal dorsal horn contributes to the development and maintenance of neuropathic pain following peripheral nerve injury in male rats
Brain Behav Immun. 2021 Aug 28;98:265-282. doi: 10.1016/j.bbi.2021.08.231. Online ahead of print.ABSTRACTThe lysine specific demethylase 6B (KDM6B) has been implicated as a coregulator in the expression of proinflammatory mediators, and in the pathogenesis of inflammatory and arthritic pain. However, the role of KDM6B in neuropathic pain has yet to be studied. In the current study, the neuropathic pain was determined by assessing the paw withdrawal threshold (PWT) and paw withdrawal latency (PWL) following lumbar 5 spinal nerve ligation (SNL) in male rats. Immunohistochemistry, Western blotting, qRT-PCR, and chromatin immu...
Source: Brain, Behavior, and Immunity - August 31, 2021 Category: Neurology Authors: Liren Li Liying Bai Kangli Yang Jian Zhang Yan Gao Mingjun Jiang Yin Yang Xuan Zhang Li Wang Xueli Wang Yiming Qiao Ji-Tian Xu Source Type: research
Impaired autophagy in microglia aggravates dopaminergic neurodegeneration by regulating NLRP3 inflammasome activation in experimental models of Parkinson's disease.
Abstract
Microglia-mediated inflammation plays an important role in the pathogenesis of several neurodegenerative diseases including Parkinson's disease (PD). Recently, autophagy has been linked to the regulation of the inflammatory response. However, the potential role of microglial autophagy in the context of PD pathology has not been characterized. In the present study, we investigated whether impaired microglial autophagy would affect dopaminergic neurodegeneration and neuroinflammation both in vivo and in vitro. In vitro, BV2 microglial cells were exposed to LPS in the presence or absence of autophagy-related...
Source: Brain, Behavior, and Immunity - October 8, 2020 Category: Neurology Authors: Qin Y, Qiu J, Wang P, Liu J, Zhao Y, Jiang F, Lou H Tags: Brain Behav Immun Source Type: research
PARP-1-regulated TNF- α expression in the dorsal root ganglia and spinal dorsal horn contributes to the pathogenesis of neuropathic pain in rats.
PARP-1-regulated TNF-α expression in the dorsal root ganglia and spinal dorsal horn contributes to the pathogenesis of neuropathic pain in rats.
Brain Behav Immun. 2020 Apr 10;:
Authors: Gao Y, Bai L, Zhou W, Yang Y, Zhang J, Li L, Jiang M, Mi Y, Li TT, Zhang X, Zhang W, Xu JT
Abstract
Emerging evidence has implicated poly-(ADP-ribose) polymerase 1 (PARP-1), a transcriptional coregulator, in a variety of inflammatory diseases. In the current study, the role of PARP-1 in neuropathic pain and the underlying mechanisms were investigated. Neuropathic pain was determined by assessing the paw withdrawal th...
Source: Brain, Behavior, and Immunity - April 9, 2020 Category: Neurology Authors: Gao Y, Bai L, Zhou W, Yang Y, Zhang J, Li L, Jiang M, Mi Y, Li TT, Zhang X, Zhang W, Xu JT Tags: Brain Behav Immun Source Type: research
TIMP-1: a key cytokine released from activated astrocytes protects neurons and ameliorates cognitive behaviours in a rodent model of Alzheimer's disease.
Abstract
Alzheimer's disease (AD) is characterized by two pathologic species, extracellular amyloid-β (Aβ) plaques and intracellular neurofibrillary tangles. Astrocytes that maintain normal homeostasis in the brain undergo a set of molecular, cellular and functional changes called reactive astrogliosis in various neurological diseases including AD. It is hypothesized that reactive astrocytes initially tend to protect neurons by reducing Aβ load and by secreting a plethora of cytokines, however, their functions have only been poorly investigated. Our studies on the kinetics of activation of cortical astrocytes f...
Source: Brain, Behavior, and Immunity - March 15, 2020 Category: Neurology Authors: Saha P, Sarkar S, Ramesh Kumar P, Biswas SC Tags: Brain Behav Immun Source Type: research
Evidence that NLRC4 Inflammasome Mediates Apoptotic and Pyroptotic Microglial Death Following Ischemic Stroke.
This study has comprehensively investigated the expression and activation of NLRP1, NLRP3, NLRC4 and AIM2 inflammasomes in isolates of microglial cells subjected to simulated ischemic conditions and in the brain following ischemic stroke. Immunoblot analysis from culture media indicated microglial cells release inflammasome components and inflammasome activation-dependent pro-inflammatory cytokines following ischemic conditions. In addition, a functional role for NLRC4 inflammasomes was determined using siRNA knockdown of NLRC4 and pharmacological inhibitors of caspase-1 and -8 to target apoptotic and pyroptotic cell death...
Source: Brain, Behavior, and Immunity - September 5, 2018 Category: Neurology Authors: Poh L, Kang SW, Baik SH, Yong Quan Ng G, She DT, Balaganapathy P, Thameem Dheen S, Magnus T, Gelderblom M, Sobey CG, Koo EH, Fann DY, Arumugam TV Tags: Brain Behav Immun Source Type: research
DNA binding protein HMGB1 secreted by activated microglia promotes the apoptosis of hippocampal neurons in diabetes complicated with OSA.
Abstract
Type 2 diabetes mellitus (T2DM) complicated with obstructive sleep apnea (OSA) may cause neuronal apoptosis and cognitive deficits, but the underlying mechanisms remain unclear. We aimed to determine the relationship between the activation of microglia and the apoptosis of hippocampal neurons, specifically in terms of high mobility group box-1 (HMGB1), after high glucose (HG) and intermittent hypoxia (IH) exposure. Diabetic KK-Ay mice and non-diabetic C57BL/6J mice (C57 mice) underwent IH or normoxia (control) exposure for 4 weeks. Cognitive function, microglial activation and hippocampal neuronal apoptos...
Source: Brain, Behavior, and Immunity - June 16, 2018 Category: Neurology Authors: Shi Y, Guo X, Zhang J, Zhou H, Sun B, Feng J Tags: Brain Behav Immun Source Type: research
Inhibition of immunoproteasome promotes angiogenesis via enhancing hypoxia-inducible factor-1 α abundance in rats following focal cerebral ischaemia.
In this study, we identified that inhibition of immunoproteasome LMP2 was able to enhance angiogenesis and facilitate neurological functional recovery in rats after focal cerebral ischemia/reperfusion. In vitro, oxygen-glucose deprivation and reperfusion (OGD/R) significantly enhanced the expression of immunoproteasome LMP2 and proteasome activities in primary culture astrocytes, but these beneficial effects were abolished by knockdown of LMP2 with siRNA tranfection. Along with this, protein abundance of HIF-1α was significantly increased by inhibition LMP2 in vivo and in vitro and was associated with angiogenesis and cel...
Source: Brain, Behavior, and Immunity - April 18, 2018 Category: Neurology Authors: Chen X, Zhang X, Chen T, Jiang X, Wang X, Lei H, Wang Y Tags: Brain Behav Immun Source Type: research
Recombinant Netrin-1 Binding UNC5B Receptor Attenuates Neuroinflammation and Brain Injury via PPAR γ/NFκB Signaling Pathway after Subarachnoid Hemorrhage in Rats.
In conclusion, our findings indicated that exogenous rh-NTN-1 treatment attenuated neuroinflammation and neurological impairments through inhibiting microglia activation after SAH in rats, which is possibly mediated by UNC5B/PPARγ/NFκB signaling pathway. Exogenous NTN-1 may be a novel therapeutic agent to ameliorating early brain injury via its anti-inflammation effect.
PMID: 29162556 [PubMed - as supplied by publisher]
Source: Brain, Behavior, and Immunity - November 18, 2017 Category: Neurology Authors: Xie Z, Huang L, Enkhjargal B, Reis C, Wan W, Tang J, Cheng Y, Zhang JH Tags: Brain Behav Immun Source Type: research
AKAP150 involved in Paclitaxel-Induced Neuropathic Pain via Inhibiting CN/NFAT2 pathway and downregulating IL-4.
In this study, we found that A-kinase anchor protein 150 (AKAP150) was significantly upregulated after paclitaxel injection. Inhibition of AKAP150 via siRNA or AKAP150(flox/flox) in rodents alleviated the pain behavior induced by paclitaxel, and partly restored the decreased calcineurin (CN) phosphatase activity after paclitaxel treatment. Paclitaxel decreased the expression of anti-inflammatory cytokine interleukin-4 (IL-4), and intrathecal injections of IL-4 effectively alleviated paclitaxel-induced hypersensitivity and the frequency of dorsal root ganglion (DRG) neurons action potential. The decreased CN enzyme activity...
Source: Brain, Behavior, and Immunity - October 19, 2017 Category: Neurology Authors: Nie B, Liu C, Bai X, Chen X, Wu S, Zhang S, Huang Z, Xie M, Xu T, Xin W, Zeng W, Ouyang H Tags: Brain Behav Immun Source Type: research
A Novel Role for Osteopontin in Macrophage-Mediated Amyloid- β Clearance in Alzheimer's Models.
This study demonstrates that OPN is an essential modulator of macrophage phenotype and their ability to clear pathogenic Aβ forms.
PMID: 28860067 [PubMed - as supplied by publisher]
Source: Brain, Behavior, and Immunity - August 28, 2017 Category: Neurology Authors: Rentsendorj A, Sheyn J, Fuchs DT, Daley D, Salumbides BC, Schubloom HE, Hart NJ, Li S, Hayden EY, Teplow DB, Black KL, Koronyo Y, Koronyo-Hamaoui M Tags: Brain Behav Immun Source Type: research
Transforming growth factor-beta 1 signaling regulates neuroinflammation and apoptosis in mild traumatic brain injury.
In conclusion, this study could establish the significance of TGF-β1 in transforming the pathophysiology of mTBI into secondary injury.
PMID: 28433746 [PubMed - as supplied by publisher]
Source: Brain, Behavior, and Immunity - April 19, 2017 Category: Neurology Authors: Patel RK, Prasad N, Kuwar R, Haldar D, Abdul-Muneer PM Tags: Brain Behav Immun Source Type: research
Cynandione A attenuates neuropathic pain through p38 β MAPK-mediated spinal microglial expression of β-endorphin.
This study aims to evaluate the antihypersensitivity activities of cynandione A in neuropathy and explored its mechanisms of action. Intrathecal injection of cynandione A dose-dependently attenuated spinal nerve ligation-induced mechanical allodynia and thermal hyperalgesia, with maximal possible effects of 57% and 59%, ED50s of 14.9 μg and 6.5 μg, respectively. Intrathecal injection of cynandione A significantly increased β-endorphin levels in spinal cords of neuropathic rats and its treatment concentration-dependently induced β-endorphin expression in cultured primary microglia (but not in neurons or astrocytes), wit...
Source: Brain, Behavior, and Immunity - February 7, 2017 Category: Neurology Authors: Huang Q, Mao XF, Wu HY, Liu H, Sun ML, Wang X, Wang YX Tags: Brain Behav Immun Source Type: research
Neuronal Fc-epsilon receptor I contributes to antigen-evoked pruritus in a murine model of ocular allergy.
This study may suggest a novel mechanism for the development of pathological itch in allergic diseases.
PMID: 27865948 [PubMed - as supplied by publisher]
Source: Brain, Behavior, and Immunity - November 15, 2016 Category: Neurology Authors: Liu F, Xu L, Chen N, Zhou M, Li C, Yang Q, Xie Y, Huang Y, Ma C Tags: Brain Behav Immun Source Type: research
