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13-Ethylberberine reduces HMGB1 release through AMPK activation in LPS-activated RAW264.7 cells and protects endotoxemic mice from organ damage.
Abstract High mobility group box 1 (HMGB1), a highly conserved non-histone DNA-binding protein, plays an important role in the pathogenesis of sepsis. Previously, the authors reported 13-ethylberberine (13-EBR) has anti-inflammatory and antibacterial effects. However, the effect of 13-EBR on HMGB1 release was not investigated. In the present study, it was hypothesized 13-EBR might reduce HMGB1 release by activating AMPK under septic conditions. The results obtained showed 13-EBR significantly reduced HMGB1 release from LPS-activated RAW264.7 cells, and that this reduction was reversed by silencing p38, or AMPK, or...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 6, 2016 Category: Drugs & Pharmacology Authors: Lee DU, Ko YS, Kim HJ, Chang KC Tags: Biomed Pharmacother Source Type: research

NOX2-ROS-HIF-1 α signaling is critical for the inhibitory effect of oleanolic acid on rectal cancer cell proliferation.
NOX2-ROS-HIF-1α signaling is critical for the inhibitory effect of oleanolic acid on rectal cancer cell proliferation. Biomed Pharmacother. 2016 Dec 06;: Authors: Guo Y, Han B, Luo K, Ren Z, Cai L, Sun L Abstract Rectal cancer is the second leading cause of cancer mortality in the western countries and accounts for 10% incidence and mortality of cancer in the whole world. Drug resistance and severe toxicity severely limited the efficiency of chemotherapy of rectal cancer. Oleanolic acid (OA) is a natural triterpenoid and an aglycone of many saponins. In the present study, we aimed to investigate the ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 5, 2016 Category: Drugs & Pharmacology Authors: Guo Y, Han B, Luo K, Ren Z, Cai L, Sun L Tags: Biomed Pharmacother Source Type: research

MicroRNA138 regulates keratin 17 protein expression to affect HaCaT cell proliferation and apoptosis by targeting hTERT in psoriasis vulgaris.
Abstract The purpose of this study is to explore the how microRNA-138 (miR-138) affects the expression of keratin 17 (K17) and psoriasis development. Twenty-eight skin lesions from patients with psoriasis vulgaris and twenty-four normal skin tissues from healthy controls were collected. The HaCaT cells were assigned into blank, negative control (NC), miR-138 mimic, miR-138 inhibitor, hTERT siRNA and miR-138 inhibitor+hTERT siRNA groups. Quantitative real-time polymerase chain reaction (qRT-PCR) was performed to detect the miR-138 expression. The hTERT and K17 protein expression were testified by Western Blotting. ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 5, 2016 Category: Drugs & Pharmacology Authors: Feng SJ, Chu RQ, Ma J, Wang ZX, Zhang GJ, Yang XF, Song Z, Ma YY Tags: Biomed Pharmacother Source Type: research

Suppression of protein tyrosine phosphatase PTPN22 gene induces apoptosis in T-cell leukemia cell line (Jurkat) through the AKT and ERK pathways.
In this study, Jurkat cells were transfected with specific PTPN22 siRNA. Relative PTPN22 mRNA expression was measured by Quantitative Real-time PCR. Western blotting was performed to determine the protein levels of PTPN22, AKT, P-AKT, ERK, and P-ERK. The cytotoxic effects of PTPN22 siRNA were determined using the MTT assay. Apoptosis was quantified using TUNEL assay and flow cytometry. Results showed that in Jurkat cells after transfection with PTPN22 siRNA, the expression of PTPN22 in both mRNA and protein levels was effectively reduced. Moreover, siRNA transfection induced apoptosis on the viability of T-cell acute leuke...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 5, 2016 Category: Drugs & Pharmacology Authors: Baghbani E, Baradaran B, Pak F, Mohammadnejad L, Shanehbandi D, Mansoori B, Khaze V, Montazami N, Mohammadi A, Kokhaei P Tags: Biomed Pharmacother Source Type: research

PGC-1 alpha interacts with microRNA-217 to functionally regulate breast cancer cell proliferation.
CONCLUSION: MiR-217 is the upstream regulator of PGC-1α in breast cancer regulation in vitro, possibly independent of DACH1 signaling pathway. PMID: 27916422 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 30, 2016 Category: Drugs & Pharmacology Authors: Zhang S, Liu X, Liu J, Guo H, Xu H, Zhang G Tags: Biomed Pharmacother Source Type: research

Inhibition of long non-coding RNA IGF2AS protects apoptosis and neuronal loss in anesthetic-damaged mouse neural stem cell derived neurons.
CONCLUSIONS: Inhibiting endogenous IGF2AS can protect anesthetic-induced neurotoxicity in neural stem cells, possibly through complimentary IGF2 upregulation and its associated downstream signaling pathways. PMID: 27914827 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 29, 2016 Category: Drugs & Pharmacology Authors: Song C, Song C, Chen K, Zhang X Tags: Biomed Pharmacother Source Type: research

Rapamycin inhibits the proliferation of endothelial cells in hemangioma by blocking the mTOR-FABP4 pathway.
In this study, we investigated whether FABP4 directly regulates the proliferation of HemECs. The expression of cell cycle checkpoint genes was analyzed with the microarray data of human dermal microvascular endothelial cells (HDVECs) and infantile hemangioma endothelial cells. Real-time RT-PCR and western blotting were used to examine the expression of FABP4 in HemECs. Next, the FABP4 expression was inhibited in HemECs using siRNA or rapamycin and upregulated using retroviral transduction of HemECs to assess its influence on proliferation of HemECs. The microarray data showed that cell cycle checkpoint genes were upregulat...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 29, 2016 Category: Drugs & Pharmacology Authors: Wang Y, Chen J, Tang W, Zhang Y, Li X Tags: Biomed Pharmacother Source Type: research

Icaritin induces mitochondrial apoptosis by up-regulating miR-124 in human oral squamous cell carcinoma cells.
CONCLUSION: Our data provide the first experimental evidence that icaritin induces mitochondrial apoptosis in OSCC cells by upregulating miR-124 and suggest a new mechanism to explain its anti-tumor effects. PMID: 27889233 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 22, 2016 Category: Drugs & Pharmacology Authors: Jin L, Miao J, Liu Y, Li X, Jie Y, Niu Q, Han X Tags: Biomed Pharmacother Source Type: research

Elucidating the role of the FoxO3a transcription factor in the IGF-1-induced migration and invasion of uveal melanoma cancer cells.
Abstract Uveal melanoma (UM) is the most common primary intraocular malignant tumor of adults. It has high mortality rate due to liver metastasis. However, the epidemiology and pathogenesis of liver metastasis in UM are not elucidated and there is no effective therapy available for preventing the development of this disease. IGF-1 is a growth factor involved in cell proliferation, malignant transformation and inhibition of apoptosis. In previous report, IGF-1 receptor was found to be highly expressed in UM and this was related to tumor prognosis. FoxO3a is a Forkhead box O (FOXO) transcription factor and a downstr...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 19, 2016 Category: Drugs & Pharmacology Authors: Yan F, Liao R, Farhan M, Wang T, Chen J, Wang Z, Little PJ, Zheng W Tags: Biomed Pharmacother Source Type: research

MiR-639 promoted cell proliferation and cell cycle in human thyroid cancer by suppressing CDKN1A expression.
Abstract Accumulating evidence has indicated that aberrantly expressed microRNAs (miRs) are extensively involved in cancer development and progression. MiR-639 has been reported to act as tumor promoter in various types of cancer. However, the biological function and underlying molecular mechanism of miR-639 in thyroid carcinoma (TC) have not been intensively investigated. Herein the present study aimed to investigate the functional role of miR-639 in TC. We found that miR-639 expression was upregulated in TC cells and clinical tissues. Overexpression of miR-639 promoted TC cell proliferation and cell cycle, with ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 5, 2016 Category: Drugs & Pharmacology Authors: Lei ST, Shen F, Chen JW, Feng JH, Cai WS, Shen L, Hu ZW, Xu B Tags: Biomed Pharmacother Source Type: research

Targeting autophagy augments the activity of DHA-E3 to overcome p-gp mediated multi-drug resistance.
In this study, we further evaluated the reversal effect of DHA-E3 on MDR and explored its mechanism of action in vitro. Our findings showed that DHA-E3 significantly potentiated the cytotoxicity of vincristine(VCR) and adriamycin(ADR) in the P-gp over-expressing KB/VCR and A02 cells. The mechanistic study found that DHA-E3 increased the intracellular accumulation of ADR and rhodamine-123 by directly inhibiting the drug-transport activity of P-gp. In the present study, we found that DHA-E3 not only reversed MDR, but also induced autophagy in MDR cancer cells. To determine whether DHA-E3-induced autophagy is an adaptive surv...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 4, 2016 Category: Drugs & Pharmacology Authors: Xi G, Wang M, Sun B, Shaikh AS, Liu Y, Wang W, Lou H, Yuan H Tags: Biomed Pharmacother Source Type: research

The role of microRNAs in colorectal cancer.
Abstract Colorectal cancer (CRC) is still the third most common cancer in the world. Mechanism of CRC tumorigenesis has been widely studied at the molecular levels, and has been recently entered the area of microRNAs. MicroRNAs are small 19 to 22 nucleotides of RNA that engage in the regulation of cell differentiation, apoptosis, and cell cycle progression. MicroRNAs are similar to small interfering RNA (siRNA), that post-transcriptionally regulate gene expression and control various cellular mechanisms. They are important factors in the carcinogenesis of CRC, one of the most important factors includes microRNA. M...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 30, 2016 Category: Drugs & Pharmacology Authors: Mohammadi A, Mansoori B, Baradaran B Tags: Biomed Pharmacother Source Type: research

Effect of notch1,2,3 genes silicing on NF- κB signaling pathway of macrophages in patients with atherosclerosis.
CONCLUSIONS: There was a positive regulation between Notch and NF-κB signaling pathway in patients with AS. Notch1 may play a more important role than notch2 and notch 3 in the regulation of NF-κB signaling pathway in AS. PMID: 27697639 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 29, 2016 Category: Drugs & Pharmacology Authors: Ruan ZB, Fu XL, Li W, Ye J, Wang RZ, Zhu L Tags: Biomed Pharmacother Source Type: research

Small-molecule GSK-3 inhibitor rescued apoptosis and neurodegeneration in anesthetics-injured dorsal root ganglion neurons.
CONCLUSIONS: GSK-3 inhibitor SB216763, through PKC, is effective in protecting anesthetics-induced neurotoxicity in DRG. PMID: 27668540 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 22, 2016 Category: Drugs & Pharmacology Authors: Yu T, Lin W Tags: Biomed Pharmacother Source Type: research

BACH1 silencing by siRNA inhibits migration of HT-29 colon cancer cells through reduction of metastasis-related genes.
CONCLUSION: Our results indicated that BACH1 down-regulation in HT29 CRC cells had no effect on cell growth but did inhibit cell migration by decreasing metastasis-related genes expression. Collectively, these results suggest that BACH1 may function as an oncogenic driver in colon cancer and may represent as a potential target of gene therapy for CRC treatment. PMID: 27657827 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 18, 2016 Category: Drugs & Pharmacology Authors: Davudian S, Shajari N, Kazemi T, Mansoori B, Salehi S, Mohammadi A, Shanehbandi D, Shahgoli VK, Asadi M, Baradaran B Tags: Biomed Pharmacother Source Type: research

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