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Specialty: Drugs & Pharmacology
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie

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Total 256 results found since Jan 2013.

lncRNA NEAT1 competes against let-7a to contribute to non-small cell lung cancer proliferation and metastasis.
In conclusion, NEAT1 regulates lung cancer cell progression by competing endogenous RNA network of NEAT1/let-7a/IGF2. Our findings provide a novel insight into the biological function of NEAT1 in lung cancer and NEAT1 could be a potential therapeutic target for lung cancer. PMID: 29864936 [PubMed - in process]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 7, 2018 Category: Drugs & Pharmacology Authors: Qi L, Liu F, Zhang F, Zhang S, Lv L, Bi Y, Yu Y Tags: Biomed Pharmacother Source Type: research

Autophagy inhibition attenuates the induction of anti-inflammatory effect of catalpol in liver fibrosis.
In conclusion, catalpol relieved liver fibrosis mainly by inhibiting inflammation, and autophagy inhibition attenuated the catalpol-induced anti-inflammatory effect on liver fibrosis. PMID: 29864907 [PubMed - in process]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 7, 2018 Category: Drugs & Pharmacology Authors: Liu Z, Zhu P, Zhang L, Xiong B, Tao J, Guan W, Li C, Chen C, Gu J, Duanmu J, Zhang W Tags: Biomed Pharmacother Source Type: research

GDPD5, a target of miR-195-5p, is associated with metastasis and chemoresistance in colorectal cancer.
CONCLUSION: This study identifies the gene GDPD5 as an effector of chemoresistance and metastasis in CRC. Furthermore, our results demonstrate that miR-195-5p is a potent suppressor of GDPD5 and that, as such, it significantly increases chemosensitivity and apoptosis in chemoresistant CRC cells. This study thus not only identifies potential prognostic biomarkers of CRC, but it also opens the possibility for incorporating miR-195-5p into current therapeutic regimens to overcome barriers to successful CRC treatment. PMID: 29635904 [PubMed - in process]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 14, 2018 Category: Drugs & Pharmacology Authors: Feng C, Zhang L, Sun Y, Li X, Zhan L, Lou Y, Wang Y, Liu L, Zhang Y Tags: Biomed Pharmacother Source Type: research

Avicularin reversed multidrug-resistance in human gastric cancer through enhancing Bax and BOK expressions.
In this study, we explored the hypothesis by which AL reversed 5-Fu or DDP resistance in gastric cancer and the underlying molecular mechanism. Here, in vitro, the drug-resistant cancer cells were incubated to AL or DDP alone or the combination of AL and DDP. Then, MTT, colony formation, Hoechst 33258, flow cytometry and western blot analysis were used to investigate the effects of AL in the regulation of drug-resistance gastric cancer cells. The results indicated that AL treatment markedly re-sensitizes the drug resistant cells (SGC-7901/5-Fu and SGC-7901/DDP) to cytotoxicity of 5-Fu or DDP. Molecular mechanism analysis i...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 7, 2018 Category: Drugs & Pharmacology Authors: Guo XF, Liu JP, Ma SQ, Zhang P, Sun WD Tags: Biomed Pharmacother Source Type: research

Suppression of Nrf2 confers chemosensitizing effect through enhanced oxidant-mediated mitochondrial dysfunction.
In this study, we investigated the mechanism of this chemosensitizing effect. MAIN METHODS: KKU-100 cells were used in the study. Nrf2 expression was knocked down by siRNA and expression was validated by reverse transcription and polymerase chain reaction. Cytotoxicity was assessed by sulforhodamine B method. Intracellular reactive oxygen species (ROS) was examined by fluorescent dye, dichlorofluorescin diacetate method and mitochondrial transmembrane potential was assessed by JC1 dye assay. KEY FINDINGS: Cytotoxicity of cisplatin (Cis) in KKU-100 cells was enhanced by knockdown of Nrf2 expression. The enhanced c...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 5, 2018 Category: Drugs & Pharmacology Authors: Sompakdee V, Prawan A, Senggunprai L, Kukongviriyapan U, Samathiwat P, Wandee J, Kukongviriyapan V Tags: Biomed Pharmacother Source Type: research

Dihydromyricetin ameliorates foam cell formation via LXR α-ABCA1/ABCG1-dependent cholesterol efflux in macrophages.
Dihydromyricetin ameliorates foam cell formation via LXRα-ABCA1/ABCG1-dependent cholesterol efflux in macrophages. Biomed Pharmacother. 2018 Mar 02;101:543-552 Authors: Zeng Y, Peng Y, Tang K, Wang YQ, Zhao ZY, Wei XY, Xu XL Abstract As the most abundant flavonoid in Ampelopsis grossedentata, the protective effects of dihydromyricetin on atherosclerosis have been well established, yet the detailed mechanisms are not fully understood. The aim of the present study was to examine the effect of dihydromyricetin on lipid accumulation and the underlying molecular mechanisms in macrophages and ApoE-/- mice....
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 2, 2018 Category: Drugs & Pharmacology Authors: Zeng Y, Peng Y, Tang K, Wang YQ, Zhao ZY, Wei XY, Xu XL Tags: Biomed Pharmacother Source Type: research

MiR-204-5p regulates C2C12 myoblast differentiation by targeting MEF2C and ERR γ.
In this study, we found that miR-204-5p expression gradually decreased when myoblasts were induced to differentiate. Our results suggested that miR-204-5p blunted myoblast differentiation, which was accompanied with a decreased proportion of myosin heavy chain (MyHC)-positive cells in myoblasts with augmented expression of miR-204-5p. Furthermore, overexpression of miR-204-5p significantly decreased the MyHC composition of slow-twitch fibers in myoblasts. Luciferase activity assays confirmed that miR-204-5p directly targeted the 3'-untranslated region (3'-UTR) of myocyte enhancer factor 2C (MEF2C) and estrogen-related rece...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 1, 2018 Category: Drugs & Pharmacology Authors: Cheng X, Du J, Shen L, Tan Z, Jiang D, Jiang A, Li Q, Tang G, Jiang Y, Wang J, Li X, Zhang S, Zhu L Tags: Biomed Pharmacother Source Type: research

Dual function of programmed cell death 10 (PDCD10) in drug resistance.
Abstract Drug resistance, a major challenge in cancer chemotherapy, is a result of several mechanistic alterations including resistance to apoptosis. Apoptosis is a well-controlled cell death mechanism which is regulated by several signaling pathways. Alterations in structure, function, and expression pattern of the proteins involved in the regulation of apoptosis have been linked to drug resistance. Programmed Cell Death 10 (PDCD10) protein is recently associated with the regulation of cell survival and apoptosis. However, the role of PDCD10 in drug resistance has not been clearly established. Here, we aimed to f...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - February 23, 2018 Category: Drugs & Pharmacology Authors: Urfali-Mamatoglu C, Kazan HH, Gündüz U Tags: Biomed Pharmacother Source Type: research

Activation of PPAR γ mediates icaritin-induced cell cycle arrest and apoptosis in glioblastoma multiforme.
CONCLUSION: Our results suggest the PPARγ may mediate anti-neoplastic activities against GBM. PMID: 29453045 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - February 13, 2018 Category: Drugs & Pharmacology Authors: Liu Y, Shi L, Liu Y, Li P, Jiang G, Gao X, Zhang Y, Jiang C, Zhu W, Han H, Ju F Tags: Biomed Pharmacother Source Type: research

MicroRNA-519d inhibits proliferation and induces apoptosis of human hypertrophic scar fibroblasts through targeting Sirtuin 7.
This study suggests that miR-519d may serve as a promising therapeutic target for treatment of human HS. PMID: 29428666 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - February 8, 2018 Category: Drugs & Pharmacology Authors: Zhou X, Xie Y, Xiao H, Deng X, Wang Y, Jiang L, Liu C, Zhou R Tags: Biomed Pharmacother Source Type: research

WISP3 prevents fibroblast-myofibroblast transdifferentiation in NRK-49F cells.
In conclusion, the WISP3 played an anti-fibrotic role in NRK-49F cells, and WNT signaling pathway was the potential mechanism. WISP3 was an anti-fibrotic factor in fibroblast-myofibroblast transdifferentiation, and may be used as a possible target for prevention and treatment of human renal fibrosis. PMID: 29353205 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - January 17, 2018 Category: Drugs & Pharmacology Authors: Yi Y, Ma J, Jianrao L, Wang H, Zhao Y Tags: Biomed Pharmacother Source Type: research

Suppression of Capn4 by microRNA-1271 impedes the proliferation and invasion of colorectal cancer cells.
In this study, we aimed to investigate the potential role of Capn4 in CRC and the regulation of Capn4 by microRNAs (miRNAs). Here, we found that Capn4 expression was highly up-regulated in CRC cell lines. Knockdown of Capn4 by siRNA significantly inhibited the proliferation and invasion of CRC cell lines. Furthermore, knockdown of Capn4 suppressed Wnt signaling in CRC cells. Interestingly, Capn4 was found to be a target gene of miR-1271, a tumor suppressive miRNA. The results showed that miR-1271 negatively regulated Capn4 expression in CRC cells. An inverse correlation between miR-1271 and Capn4 was also shown in CRC clin...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - January 10, 2018 Category: Drugs & Pharmacology Authors: Li J, Xu J, Yan X, Jin K, Li W, Zhang R Tags: Biomed Pharmacother Source Type: research

DJ-1 preserving mitochondrial complex I activity plays a critical role in resveratrol-mediated cardioprotection against hypoxia/reoxygenation-induced oxidative stress.
Abstract Resveratrol has been demonstrated to have cardioprotective effects by attenuating ischemia/reperfusion (I/R)-induced oxidative stress injury, but its in-depth molecular mechanisms against I/R-induced oxidative stress is not fully elaborated. DJ-1 plays a role in maintenance of mitochondrial complex I activity and is closely associated with oxidative stress. Therefore, this study sought to determine the contribution of DJ-1-mediated maintenance of mitochondrial complex I activity to the anti-oxidative stress effect of Resveratrol in the H9c2 cardiomyocytes subjected to hypoxia/reoxygenation (H/R). The resu...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 26, 2017 Category: Drugs & Pharmacology Authors: Zhang Y, Li XR, Zhao L, Duan GL, Xiao L, Chen HP Tags: Biomed Pharmacother Source Type: research

Lin28a functionally modulates bupivacaine-induced dorsal root ganglion neuron apoptosis through TrkA activation.
CONCLUSION: Lin28a is a potent regulator in BUP-induced neuronal apoptosis in DRGNs. The apoptotic protection by Lin28a inhibition is likely through the activation of TrkA signaling pathway. PMID: 29245067 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 12, 2017 Category: Drugs & Pharmacology Authors: Yu L, Jiang Y, Tang B Tags: Biomed Pharmacother Source Type: research

Insights on ornithine decarboxylase silencing as a potential strategy for targeting retinoblastoma.
Abstract Ornithine Decarboxylase (ODC) is a key enzyme involved in polyamine synthesis and is reported to be up regulated in several cancers. However, the effect of ODC gene silencing in retinoblastoma is to be understood for utilization in therapeutic applications. Hence, in this study, a novel siRNA (small interference RNA) targeting ODC was designed and validated in Human Y79 retinoblastoma cells for its effects on intracellular polyamine levels, Matrix Metalloproteinase 2 & 9 activity and Cell cycle. The designed siRNA showed efficient silencing of ODC mRNA expression and protein levels in Y79 cells. It al...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 11, 2017 Category: Drugs & Pharmacology Authors: Muthukumaran S, Bhuvanasundar R, Umashankar V, Sulochana KN Tags: Biomed Pharmacother Source Type: research