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Gut-muscle axis and sepsis-induced myopathy: The potential role of gut microbiota
Biomed Pharmacother. 2023 May 6;163:114837. doi: 10.1016/j.biopha.2023.114837. Online ahead of print.ABSTRACTSepsis is described as an immune response disorder of the host to infection in which microorganisms play a non-negligible role. Most survivors of sepsis experience ICU-acquired weakness, also known as septic myopathy, characterized by skeletal muscle atrophy, weakness, and irreparable damage/regenerated or dysfunctional. The mechanism of sepsis-induced myopathy is currently unclear. It has been believed that this state is triggered by circulating pathogens and their related harmful factors, leading to impaired muscl...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 8, 2023 Category: Drugs & Pharmacology Authors: Yukun Liu Ligang Xu Zhaohui Yang Dongfang Wang Tianyu Li Fan Yang Zhanfei Li Xiangjun Bai Yuchang Wang Source Type: research

Protective effect of Lactococcus laudensis and Pediococcus parvulus against neuropathy due to amyloid-beta in Caenorhabditis elegans
In conclusion, LL and PP alleviate neurotoxicity by inhibiting Aβ accumulation; AD model worms can be used to screen efficient LAB for AD prevention.PMID:36271552 | DOI:10.1016/j.biopha.2022.113769
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - October 22, 2022 Category: Drugs & Pharmacology Authors: Tomomi Komura Motoshi Aoki Satoshi Kotoura Yoshikazu Nishikawa Source Type: research

Therapeutic advancement of simvastatin-loaded solid lipid nanoparticles (SV-SLNs) in treatment of hyperlipidemia and attenuating hepatotoxicity, myopathy and apoptosis: Comprehensive study
This study set out to optimize simvastatin (SV) in lipid nanoparticles (SLNs) to improve bioavailability, efficacy and alleviate adverse effects. Simvastatin-loaded solid lipid nanoparticles (SV-SLNs) were prepared by hot-melt ultrasonication method and optimized by box-Behnken experimental design. Sixty Wister albino rats were randomly assigned into six groups and treated daily for 16 weeks: control group, the group fed with 20 g of high-fat diet (HFD), group treated with vehicle (20 mg/kg, P.O.) for last four weeks, group treated with HFD and SV (20 mg/kg, P.O.) / or SV-SLNs (20 mg/kg/day, P.O.) / or SV-SLNs (5 mg/kg, P....
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 10, 2021 Category: Drugs & Pharmacology Authors: Hagar B Abo-Zalam Ezzeldein S El-Denshary Rania M Abdelsalam Islam A Khalil Mahmoud M Khattab Mohamed A Hamzawy Source Type: research