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Source: Biochemical and Biophysical Research communications
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Total 596 results found since Jan 2013.
Silencing of novel TtVtg6-like induced ovarian cell apoptosis in ancient chelicerate Tachypleus tridentatus
In this study, we have successfully elucidated the complete transcript sequence of TtVtg6-like from an ancient chelicerate Tachypleus tridentatus. The TtVtg6-like transcript encompassed a length of 4887 bp and encoded 1629 amino acids residues. Notably, TtVtg6-like was found to contain 25 exons. Furthermore, the molecular weight and isoelectric point of TtVtg6-like were determined to be 191.6 KDa and 6.73, respectively. Subsequent mRNA expression analysis demonstrated the specific expression of TtVtg6-like in ovary and yellow connective tissue. In addition, TtVtg6-like was located and distributed in both ovary and yellow c...
Source: Biochemical and Biophysical Research communications - September 6, 2023 Category: Biochemistry Authors: Kianann Tan Khor Waiho Karsoon Tan Ying Qiao Leong-Seng Lim Xin Yang Yulong Wen Peng Xu Ya Peng Xiaowan Ma Kit Yue Kwan Source Type: research
3-deazaneplanocin A, a histone methyltransferase inhibitor, improved the chemoresistance induced under hypoxia in melanoma cells
In conclusion, a histone methyltransferase EZH2 inhibitor, DZNep was capable of tackling acquired chemoresistance via the suppression of histone methylation induced under hypoxic tumor microenvironment.PMID:37542772 | DOI:10.1016/j.bbrc.2023.08.003
Source: Biochemical and Biophysical Research communications - August 5, 2023 Category: Biochemistry Authors: Mika Hosokawa Sekai Tetsumoto Mirano Yasui Yusuke Kono Ken-Ichi Ogawara Source Type: research
AMPK boosts ADAM10 shedding activity in human aortic endothelial cells by promoting Rab14-dependent ADAM10 cell surface translocation
In conclusion, AMPK activation is an obvious inducer of ADAM10 shedding activity. Our findings suggest that AMPK boosts ADAM10 shedding activity in HAECs by promoting Rab14-dependent ADAM10 cell surface translocation.PMID:37451218 | DOI:10.1016/j.bbrc.2023.07.010
Source: Biochemical and Biophysical Research communications - July 14, 2023 Category: Biochemistry Authors: Chung Hee Baek Hyosang Kim Soo Young Moon Won Seok Yang Source Type: research
MESP1-knockdown inhibits the proliferation and epithelial mesenchymal transition of hepatocellular carcinoma and enhances the tumor-suppressive effect of 5-fluorouracil
Biochem Biophys Res Commun. 2023 May 29;670:1-11. doi: 10.1016/j.bbrc.2023.05.036. Online ahead of print.ABSTRACTPrimary liver hepatocellular carcinoma (HCC) is the third most deadly malignancy worldwide,in part, because it is often diagnosed at an advanced stage. Thus, molecular markers are needed to aid in the early diagnosis and treatment of HCC. Expression of abnormal mesoderm posterior-1 (MESP1) promotes tumorigenesis; however,its role in the regulation of HCC proliferation, apoptosis,and invasion is unknown. Here,we analyzed data in The Cancer Genome Atlas (TCGA)and Genotype Tissue Expression (GTEx) databases on the ...
Source: Biochemical and Biophysical Research communications - June 4, 2023 Category: Biochemistry Authors: Shuqin Ji Man Xu Chenyu Cai Xinyue He Source Type: research
Gut microbiota metabolite TMAO promoted lipid deposition and fibrosis process via KRT17 in fatty liver cells in vitro
In conclusion, the gut microbiota metabolite TMAO could promote lipid deposition and fibrosis process via the KRT17 gene in fatty liver cells in vitro.PMID:37271025 | DOI:10.1016/j.bbrc.2023.05.041
Source: Biochemical and Biophysical Research communications - June 4, 2023 Category: Biochemistry Authors: Fulin Nian Chen Zhu Nuyun Jin Qiaoyun Xia Longyun Wu Xiaolan Lu Source Type: research
DKK1-targeting cholesterol-modified siRNA implication in hair growth regulation
In this report, we have selected a small interfering RNA (siRNA) targeting DKK1 in vitro via qPCR and then tested its efficacy in vivo on the depilated dorsal skin of the mice. The changes in hair growth in different groups were observed over time. Moreover, the visual observation of the hair growth and hematoxylin and eosin (HE) staining showed that DKK1-targeting siRNA reveals non-inferior results compared with the mice treated with the Food and Drug Administration (FDA)-approved, commercially available minoxidil (5%) topical solution that was used as a positive control. Both- positive control and DKK1-targeting siRNA gr...
Source: Biochemical and Biophysical Research communications - May 27, 2023 Category: Biochemistry Authors: Dimitri Papukashvili Cong Liu Nino Rcheulishvili Fengfei Xie Xingyun Wang Shunping Feng Xiu Sun Chi Zhang Yingyu Li Yunjiao He Peng George Wang Source Type: research
UbcH5c-dependent activation of DNA-dependent protein kinase in response to replication-mediated DNA double-strand breaks
Biochem Biophys Res Commun. 2023 May 18;668:42-48. doi: 10.1016/j.bbrc.2023.05.068. Online ahead of print.ABSTRACTCamptothecin (CPT) exhibits strong cytotoxicity by inducing DNA double-strand breaks (DSBs) through DNA replication. Unlike radiation-induced DSBs, which have two DNA ends, CPT-induced DSBs are considered to have only one DNA end. However, the differences in cellular responses to one-ended and two-ended DSBs are not well understood. Our previous study showed that proteasome inhibitor treatment suppressed CPT-induced activation of DNA-PK, a factor required for non-homologous end-joining in DSB repair, suggesting...
Source: Biochemical and Biophysical Research communications - May 27, 2023 Category: Biochemistry Authors: Ryo Sakasai Tadashi Matsui Yumi Sunatani Kuniyoshi Iwabuchi Source Type: research
DKK1-targeting cholesterol-modified siRNA implication in hair growth regulation
In this report, we have selected a small interfering RNA (siRNA) targeting DKK1 in vitro via qPCR and then tested its efficacy in vivo on the depilated dorsal skin of the mice. The changes in hair growth in different groups were observed over time. Moreover, the visual observation of the hair growth and hematoxylin and eosin (HE) staining showed that DKK1-targeting siRNA reveals non-inferior results compared with the mice treated with the Food and Drug Administration (FDA)-approved, commercially available minoxidil (5%) topical solution that was used as a positive control. Both- positive control and DKK1-targeting siRNA gr...
Source: Biochemical and Biophysical Research communications - May 27, 2023 Category: Biochemistry Authors: Dimitri Papukashvili Cong Liu Nino Rcheulishvili Fengfei Xie Xingyun Wang Shunping Feng Xiu Sun Chi Zhang Yingyu Li Yunjiao He Peng George Wang Source Type: research
UbcH5c-dependent activation of DNA-dependent protein kinase in response to replication-mediated DNA double-strand breaks
Biochem Biophys Res Commun. 2023 May 18;668:42-48. doi: 10.1016/j.bbrc.2023.05.068. Online ahead of print.ABSTRACTCamptothecin (CPT) exhibits strong cytotoxicity by inducing DNA double-strand breaks (DSBs) through DNA replication. Unlike radiation-induced DSBs, which have two DNA ends, CPT-induced DSBs are considered to have only one DNA end. However, the differences in cellular responses to one-ended and two-ended DSBs are not well understood. Our previous study showed that proteasome inhibitor treatment suppressed CPT-induced activation of DNA-PK, a factor required for non-homologous end-joining in DSB repair, suggesting...
Source: Biochemical and Biophysical Research communications - May 27, 2023 Category: Biochemistry Authors: Ryo Sakasai Tadashi Matsui Yumi Sunatani Kuniyoshi Iwabuchi Source Type: research
Acrolein produced during acute kidney injury promotes tubular cell death
Biochem Biophys Res Commun. 2023 May 9;666:137-145. doi: 10.1016/j.bbrc.2023.05.029. Online ahead of print.ABSTRACTAcute kidney injury is an important global health concern as it is associated with high morbidity and mortality. Polyamines, essential for cell growth and proliferation, are known to inhibit cardiovascular disease. However, under conditions of cellular damage, toxic acrolein is produced from polyamines by the enzyme spermine oxidase (SMOX). We used a mouse renal ischemia-reperfusion model and human proximal tubule cells (HK-2) to investigate whether acrolein exacerbates acute kidney injury by renal tubular cel...
Source: Biochemical and Biophysical Research communications - May 15, 2023 Category: Biochemistry Authors: Seishi Aihara Kumiko Torisu Yutaro Hirashima Takanari Kitazono Toshiaki Nakano Source Type: research
MicroRNA-31 regulates TNF- α and IL-17A co-induced-endothelial cell apoptosis by repressing E2F6
In conclusion, TNF-α and IL-17A generated in the aortic vascular tissue and serum from Ang II-induced hypertensive mice could trigger VECs apoptosis by the miR-31/E2F6 axis. To sum up, our study suggests that the key factor between cytokine co-stimulation effect and VEC apoptosis was miR-31/E2F6 axis, which was mainly regulated by NF-қB signaling pathway. This gives us a new sight to treat hypertension-associated VR.PMID:37178508 | DOI:10.1016/j.bbrc.2023.05.012
Source: Biochemical and Biophysical Research communications - May 13, 2023 Category: Biochemistry Authors: Zilong Fang Xinran Tong Guangzheng Shi Wendong Chen Qun Li Source Type: research
