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c-Jun N-terminal kinase activity is required for efficient respiratory syncytial virus production.
Abstract Respiratory syncytial virus (RSV) is a major cause of respiratory infections in infants and the elderly, leading to more deaths than influenza each year worldwide. With no RSV antiviral or efficacious vaccine currently available, improved understanding of the host-RSV interaction is urgently required. Here we examine the contribution to RSV infection of the host stress-regulated c-Jun N-terminal kinase (JNK), for the first time. Peak JNK1/2 phosphoactivation is observed at ∼24 h post-infection, correlating with the time of virus assembly. The release of infectious RSV virions from infected cells was si...
Source: Biochemical and Biophysical Research communications - January 2, 2017 Category: Biochemistry Authors: Caly L, Li HM, Bogoyevitch MA, Jans DA Tags: Biochem Biophys Res Commun Source Type: research