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The expression level of the transcription factor Aryl hydrocarbon receptor nuclear translocator (ARNT) determines cellular survival after radiation treatment
Conclusions: These findings provide evidence to consider ARNT as a drug target and as a predictive marker in clinical applications concerning the response to radiation.
Source: Radiation Oncology - November 16, 2015 Category: Cancer & Oncology Authors: Markus MandlMaria- LieberumJuergen DunstReinhard Depping Source Type: research

The SMAC mimetic BV6 sensitizes colorectal cancer cells to ionizing radiation by interfering with DNA repair processes and enhancing apoptosis
Conclusion: The SMAC mimetic BV6 induced apoptosis and hampered DNA damage repair to radiosensitize 3D grown colorectal cancer cells. Our results demonstrate IAP targeting as a promising strategy to counteract radiation resistance of colorectal cancer cells.
Source: Radiation Oncology - September 17, 2015 Category: Cancer & Oncology Authors: Stephanie HehlgansJulius OppermannSebastian ReichertSimone FuldaClaus RödelFranz Rödel Source Type: research

A cell-based high-throughput screening assay for radiation susceptibility using automated cell counting
Conclusions: We developed a simple assay for radiation susceptibility that can be used for high-throughput screening. This will aid the identification of molecular targets for radiosensitization, thereby contributing to improving the efficacy of radiotherapy.
Source: Radiation Oncology - February 27, 2015 Category: Cancer & Oncology Authors: Jasmina HodzicIlse DingjanMariëlle MaasIda van der Meulen-MuilemanRenee de MenezesStan HeukelomMarcel VerheijWinald GerritsenAlbert GeldofBaukelien van TriestVictor van Beusechem Source Type: research

Down-regulation of BTG1 by miR-454-3p enhances cellular radiosensitivity in renal carcinoma cells
Conclusions: Our results indicate that BTG1 is a direct target of miR-454-3p. Down-regulation of BTG1 by miR-454-3p renders tumor cells sensitive to radiation. These results may shed light on the potential application in tumor radiotherapy.
Source: Radiation Oncology - August 12, 2014 Category: Cancer & Oncology Authors: Xin WuNan DingWentao HuJinpeng HeShuai XuHailong PeiJunrui HuaGuangming ZhouJufang Wang Source Type: research

SHP1-mediated cell cycle redistribution inhibits radiosensitivity of non-small cell lung cancer
Conclusions: SHP1 decreases the radiosensitivity of NSCLC cells through affecting cell cycle distribution. This finding could unravel the molecular mechanism involved in NSCLC radioresistance.
Source: Radiation Oncology - July 10, 2013 Category: Cancer & Oncology Authors: Rubo CaoQian DingPindong LiJun XueZhenwei ZouJing HuangGang Peng Source Type: research

The microtubule stabilizer patupilone counteracts ionizing radiation-induced matrix metalloproteinase activity and tumor cell invasion
Conclusions: These results indicate that patupilone counteracts an IR-induced MMP activation process by the reduction of secreted TIMP-1 and TIMP-2 proteins, which are required for activation of MMPs. Since IR-induced MMP activity could contribute to tumor progression, treatment combination of IR with patupilone might be of great clinical benefit for tumor therapy.
Source: Radiation Oncology - April 30, 2013 Category: Cancer & Oncology Authors: Polina Furmanova-HollensteinAngela Broggini-TenzerMatthias EggelAnne-Laure MillardMartin Pruschy Source Type: research