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Source: Cell Communication and Signaling

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Total 26 results found since Jan 2013.

The NESH/Abi-3-based WAVE2 complex is functionally distinct from the Abi-1-based WAVE2 complex
Conclusions: The NESH/Abi-3-based WAVE2 complex is functionally distinct from the Abi-1-based one, and NESH/Abi-3 may be involved in the formation of ventral protrusions under certain conditions.
Source: Cell Communication and Signaling - October 1, 2015 Category: Molecular Biology Authors: Saki SekinoYuriko KashiwagiHitoshi KanazawaKazuki TakadaTakashi BabaSeiichi SatoHiroki InoueMasaki KojimaKatsuko Tani Source Type: research

The T-box transcription factor Brachyury promotes renal interstitial fibrosis by repressing E-cadherin expression
Conclusion: Our results demonstrate for the first time that Brachyury plays an important role in regulating TGF-β1–mediated renal EMT and could be an attractive target for progression of renal disease therapies.
Source: Cell Communication and Signaling - November 30, 2014 Category: Molecular Biology Authors: Shiren SunWenjuan SunLin XiaLimin LiuRui DuLijie HeRong LiHanmin WangChen Huang Source Type: research

Nck1 depletion induces activation of the PI3K/Akt pathway by attenuating PTP1B protein expression
Conclusion: Our study provides strong evidence supporting that the adaptor protein Nck1 interacts with PTP1B and also regulates PTP1B expression. In this manner, Nck1 plays a role in regulating the PI3K/Akt pathway.
Source: Cell Communication and Signaling - November 14, 2014 Category: Molecular Biology Authors: Hui LiJulie DusseaultLouise Larose Source Type: research

The E3 ubiquitin ligase RNF121 is a positive regulator of NF-¿B activation
Conclusions: These results unveil an unexpected role of Golgi Apparatus and reveal RNF121 as a new player involved in the signaling leading to NF-κB activation.
Source: Cell Communication and Signaling - November 12, 2014 Category: Molecular Biology Authors: Naima ZemirliMarie PourcelotNeslihan DoganAimé VazquezDamien Arnoult Source Type: research

Alteration in mitochondrial Ca 2+ uptake disrupts insulin signaling in hypertrophic cardiomyocytes
Conclusions: Mitochondrial Ca2+ uptake is a key event in insulin signaling and metabolism in cardiomyocytes.
Source: Cell Communication and Signaling - November 7, 2014 Category: Molecular Biology Authors: Tomás GutiérrezValentina ParraRodrigo TroncosoChristian PennanenAriel Contreras-FerratCésar Vasquez-TrincadoPablo MoralesCamila Lopez-CrisostoCristian Sotomayor-FloresMario ChiongBeverly RothermelSergio Lavandero Source Type: research

Claudin-4 controls the receptor tyrosine kinase EphA2 pro-oncogenic switch through ß-catenin
Conclusions: We conclude that CLDN4 serves to restrain pro-oncogenic signaling from EphA2 by limiting the activity of ?-catenin and PI3K and preventing phosphorylation of EphA2 on S897 by AKT. This suggests that interventions directed at enhancing the level or functional activity of CLDN4 may be of therapeutic interest.
Source: Cell Communication and Signaling - October 25, 2014 Category: Molecular Biology Authors: Xiying ShangXinjian LinStephen Howell Source Type: research

TrkB interacts with ErbB4 and regulates NRG1-induced NR2B phosphorylation in cortical neurons before synaptogenesis
Conclusions: BDNF/TrkB signaling plays an important role in the NRG1-stimulated NR2B regulation. These findings could be of relevance to many neurodevelopmental disorders, as NRG1 and BDNF signaling pathways have been implicated in autism and schizophrenia.
Source: Cell Communication and Signaling - July 24, 2014 Category: Molecular Biology Authors: Chirayu PandyaAnilkumar Pillai Source Type: research

AhR and Arnt differentially regulate NF-¿B signaling and chemokine responses in human bronchial epithelial cells
Conclusion: AhR and Arnt may differentially and independently regulate chemokine-responses induced by both inhaled pollutants and pulmonary infections. Constitutively active, unligated AhR suppressed the activation of p65, while Arnt may possibly interfere with the action of activated p65. Moreover, ligand-activated AhR suppressed CXCL8 and CCL5 responses by other agents, but AhR ligands alone induced CXCL8 responses when given at sufficiently high concentrations, thus underscoring the duality of AhR in regulation of inflammation. We propose that AhR-signaling may be a weak activator of p65-signaling that suppresses p65-ac...
Source: Cell Communication and Signaling - July 24, 2014 Category: Molecular Biology Authors: Johan ØvrevikMarit LågValerie LecureurDavid GilotDominique Lagadic-GossmannMagne RefsnesPer SchwarzeTonje SkulandRune BecherJørn Holme Source Type: research

Divergent signaling pathways cooperatively regulate TGFbeta induction of cysteine-rich protein 2 in vascular smooth muscle cells
Conclusions: Our results demonstrate that two signaling pathways downstream of TGFbeta converge on the CRE and SBE sites of the Csrp2 promoter to cooperatively control CRP2 induction in VSMCs, which represents a previously unrecognized mechanism of VSMC gene induction by TGFbeta.
Source: Cell Communication and Signaling - March 28, 2014 Category: Molecular Biology Authors: Meng-Ling WuChung-Huang ChenYung-Tsang LinYuan-Jyun JhengYen-Chun HoLiang-Tung YangLinyi ChenMatthew LayneShaw-Fang Yet Source Type: research

Divergent signaling pathways cooperatively regulate TGFß induction of cysteine-rich protein 2 in vascular smooth muscle cells
Conclusions: Our results demonstrate that two signaling pathways downstream of TGFbeta converge on the CRE and SBE sites of the Csrp2 promoter to cooperatively control CRP2 induction in VSMCs, which represents a previously unrecognized mechanism of VSMC gene induction by TGFbeta.
Source: Cell Communication and Signaling - March 28, 2014 Category: Molecular Biology Authors: Meng-Ling WuChung-Huang ChenYung-Tsang LinYuan-Jyun JhengYen-Chun HoLiang-Tung YangLinyi ChenMatthew LayneShaw-Fang Yet Source Type: research