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The Efficacy of Olfactory Training as a Treatment for Olfactory Disorders Caused by Coronavirus Disease-2019: A Systematic Review and Meta-Analysis
CONCLUSION: Olfactory training improved olfactory disorders caused by COVID-19. Such training was effective in both the acute and chronic phases.PMID:36635974 | DOI:10.1177/19458924221150977
Source: American Journal of Rhinology and Allergy - January 13, 2023 Category: ENT & OMF Authors: Se Hwan Hwang Sung Won Kim Mohammed Abdullah Basurrah Do Hyun Kim Source Type: research

Effect of Sodium Gluconate on Decreasing Elevated Nasal Calcium and Improving Olfactory Function Post COVID-19 Infection
CONCLUSION: Based on the proposed results, sodium gluconate may associate with an improvement of the olfactory dysfunction post-COVID-19 infection.PMID:35942688 | DOI:10.1177/19458924221120116
Source: American Journal of Rhinology and Allergy - August 9, 2022 Category: ENT & OMF Authors: Mohamed H Abdelazim Ahmed H Abdelazim Source Type: research

Co-Expression and Localization of Angiotensin-Converting Enzyme-2 (ACE2) and the Transmembrane Serine Protease 2 (TMPRSS2) in Paranasal Ciliated Epithelium of Patients with Chronic Rhinosinusitis
CONCLUSION: ECRS patients with type 2 inflammation showed decreased ACE2 and TMPRSS2 expressions in their sinus mucosa. ACE2 and TMPRSS2 regulation seems to be positively related to IFN-γ and TNF-α production in CRS patients; ACE2 and TMPRSS2 were co-expressed in the ciliated epithelium of their paranasal mucosa, implicating the paranasal epithelium as a portal for initial infection and transmission.PMID:34989246 | DOI:10.1177/19458924211059639
Source: American Journal of Rhinology and Allergy - January 6, 2022 Category: ENT & OMF Authors: Tomohiro Kawasumi Sachio Takeno Takashi Ishino Tsutomu Ueda Takao Hamamoto Kota Takemoto Yuichiro Horibe Oda Takashi Source Type: research

Olfactory-related Quality of Life Adjustments in Smell Loss during the Coronavirus-19 Pandemic
CONCLUSION: We showed that patients with persistent OD experienced better olfactory-related adjustment and lower QoL-impairment scores than those with recent-onset smell loss, suggesting that the olfactory-related QoL might change as a function of time after symptom onset.PMID:34704454 | DOI:10.1177/19458924211053118
Source: American Journal of Rhinology and Allergy - October 27, 2021 Category: ENT & OMF Authors: David T Liu Bernhard Prem Gerold Besser Bertold Renner Christian A Mueller Source Type: research

Regulation of the Expression of SARS-CoV-2 Receptor Angiotensin-Converting Enzyme 2 in Nasal Mucosa
CONCLUSION: Inflammatory endotype affects ACE2 expression in the nasal mucosa and influences susceptibility to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. In particular, type 2 inflammation could downregulate ACE2 expression in the nasal mucosa and reduces susceptibility to SARS-CoV-2 in patients with CRSwNP. Although in vivo experiments are required, administration of SCFAs to the nasal cavity might be worthy of consideration as a preventative or therapeutic strategy for the early-stage COVID-19.PMID:34232770 | DOI:10.1177/19458924211027798
Source: American Journal of Rhinology and Allergy - July 7, 2021 Category: ENT & OMF Authors: Tetsuji Takabayashi Kanako Yoshida Yoshimasa Imoto Robert P Schleimer Shigeharu Fujieda Source Type: research

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