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Fetomaternal immune cross talk modifies T-cell priming through sustained changes to DC function
Prenatal exposure to infections can modify immune development. These environmental disturbances during early life potentially alter the incidence of inflammatory disorders as well as priming of immune responses. Infection with the helminth Schistosoma mansoni is widely studied for its ability to alter immune responsiveness and is associated with variations in coinfection, allergy, and vaccine efficacy in endemic populations.
Source: Journal of Allergy and Clinical Immunology - March 5, 2021 Category: Allergy & Immunology Authors: Matthew Lacorcia, Sonakshi Bhattacharjee, Kristina Laubhahn, Fahd Alhamdan, Marija Ram, Andreas Muschaweckh, Daniel P. Potaczek, Anna Kosinska, Holger Garn, Ulrike Protzer, Harald Renz, Clarissa Prazeres da Costa Source Type: research

Successful Administration of Yellow Fever Vaccine in Egg-allergic Patients
This study aims to describe the outcomes of yellow fever vaccination in patients with confirmed egg allergy (EA).
Source: Journal of Allergy and Clinical Immunology - February 1, 2019 Category: Allergy & Immunology Authors: Clarissa Morais Busatto Gerhardt, Gislane S. Juliao, Bruna Pultrini Aquilante, Cristiane N. Santos, Mayra de Barros Dorna, Antonio Carlos Pastorino, Ana Paula Moschione Castro Source Type: research

Yellow fever vaccine in egg-allergic patients: safety of a vaccination protocol
We describe the outcomes of a protocol for administration of YFV in EA patients.
Source: Journal of Allergy and Clinical Immunology - February 1, 2018 Category: Allergy & Immunology Authors: Gislane S. Juliao, Pamela A. Barbosa, Pryscilla F. Silva, Myllena A. Cunha, Caroline F. Formigari, Antonio C. Pastorino, Ana Paula C. Moschione, Mayra B. Dorna, Cristiane N. Santos Source Type: research

Identification of dominant anti-glycan IgE responses in school children by glycan microarray
In helminth-endemic areas, elevated levels of cross-reactive IgE to environmental and food allergens are often seen that do not translate into positive skin prick test results or allergy symptoms.1 Among Ghanaian children, such cross-reactivity was shown to be associated with Schistosoma haematobium infection and dominated by high IgE against cross-reactive carbohydrate determinants (CCDs).2 The specific carbohydrate motifs involved in this IgE recognition were not determined.2
Source: Journal of Allergy and Clinical Immunology - November 8, 2017 Category: Allergy & Immunology Authors: Abena S. Amoah, Elias K. Asuming-Brempong, Benedicta B. Obeng, Serge A. Versteeg, Irene A. Larbi, Yvonne Aryeetey, Thomas A.E. Platts-Mills, Adriano Mari, Katarzyna Brzezicka, Ben A. Gyan, Mohamed Mutocheluh, Daniel A. Boakye, Niels-Christian Reichardt, R Tags: Letter to the Editor Source Type: research

Molecular diagnostics and lack of clinical allergy in helminth-endemic areas in Indonesia
Allergen microarray characterization of sensitization to common allergen sources in a helminth-endemic area of Indonesia shows that helminth induced cross-reactivity to cross-reactive carbohydrate determinants (CCD), and not primary sensitization to their major allergens, is the dominant feature.
Source: Journal of Allergy and Clinical Immunology - May 24, 2017 Category: Allergy & Immunology Authors: Firdaus Hamid, Serge A. Versteeg, Aprilianto E. Wiria, Linda J. Wammes, Sitti Wahyuni, Taniawati Supali, Erliyani Sartono, Ronald van Ree, Maria Yazdanbakhsh Source Type: research

Prediction of peanut allergy in adolescence by early childhood storage protein-specific IgE signatures: The BAMSE population-based birth cohort
One of the most frequent and severe forms of food allergy is caused by peanuts.1 IgE reactivity to peanut storage proteins, in particular to Arachis hypogaea (Ara h) 2, is associated with systemic reactions.2 However, in some regions, the lipid transfer protein Ara h 9 is an important allergen molecule, whereas in birch endemic areas, the pathogenesis-related protein family 10 protein Ara h 8 is a more common cross-reactive component.3
Source: Journal of Allergy and Clinical Immunology - February 10, 2017 Category: Allergy & Immunology Authors: Anna Asarnoj, Carl Hamsten, Christian Lupinek, Erik Mel én, Niklas Andersson, Josep M. Anto, Jean Bousquet, Rudolf Valenta, Marianne van Hage, Magnus Wickman, MeDALL Consortium Tags: Letter to the Editor Source Type: research

Persistent nodal histoplasmosis in nuclear factor kappa B essential modulator deficiency: Report of a case and review of infection in primary immunodeficiencies
Histoplasma capsulatum var. capsulatum is an endemic dimorphic intracellular fungus that typically causes asymptomatic and self-limited infections in immunocompetent individuals.1 Inversely, immunocompromised patients, particularly patients with the acquired immunodeficiency syndrome and other cell-mediated immune defects, are at increased risk for disseminated histoplasmosis.1
Source: Journal of Allergy and Clinical Immunology - April 22, 2016 Category: Allergy & Immunology Authors: Jana P. Lovell, Ladan Foruraghi, Alexandra F. Freeman, Gulbu Uzel, Christa S. Zerbe, Helen Su, Amy P. Hsu, Steven M. Holland Tags: Letter to the Editor Source Type: research

Endemic mycoses in patients with -mutated hyper-IgE (Job) syndrome
STAT3-mutated hyper-IgE (Job) syndrome (STAT3 HIES) is characterized by highly elevated serum IgE level, recurrent episodes of pneumonia, eczema, skin abscesses, mucocutaneous candidiasis, and dental, vascular, and skeletal abnormalities.1 STAT3 also promotes CD4 TH17 differentiation and expression of the associated cytokines IL17 and IL22.2 TH17 cells are believed to enhance mucosal immunity through antimicrobial peptides, impairment of which may explain the typical epithelial infections in patients with STAT3 HIES.
Source: Journal of Allergy and Clinical Immunology - August 17, 2015 Category: Allergy & Immunology Authors: Camila D. Odio, Ki Lee Milligan, Katherine McGowan, Amanda K. Rudman Spergel, Rachel Bishop, Lisa Boris, Amanda Urban, Pamela Welch, Theo Heller, David Kleiner, Mary Anne Jackson, Steven M. Holland, Alexandra F. Freeman Tags: Letter to the Editor Source Type: research

Penicillium marneffei infection and impaired IFN-γ immunity in humans with autosomal-dominant gain-of-phosphorylation STAT1 mutations
Penicillium marneffei is a pathogenic fungus endemic in Southeast Asia. P marneffei was an extremely rare pathogen in humans before the HIV epidemic, but following the exponential rise in the prevalence of HIV in Southeast Asia, penicilliosis emerged as a clinically significant opportunistic infection and is classified as an AIDS-defining illness. Less commonly, penicilliosis occurs in patients with other immunodeficiencies, such as severe combined immunodeficiency, common variable immunodeficiency, hyper-IgM syndrome, hyper-IgE syndrome, the presence of anti-IFN-γ autoantibody, diabetes mellitus, immunosuppressive therap...
Source: Journal of Allergy and Clinical Immunology - November 4, 2013 Category: Allergy & Immunology Authors: Pamela P.W. Lee, Huawei Mao, Wanling Yang, Koon-Wing Chan, Marco H.K. Ho, Tsz-Leung Lee, Jasper F.W. Chan, Patrick C.Y. Woo, Wenwei Tu, Yu-Lung Lau Tags: Letters to the Editor Source Type: research

Reply
We are grateful for the comment of Seidel et al and that the AAAAI Work Group Report “Use and interpretation of diagnostic vaccination in primary immunodeficiency” is of perceived value to our colleagues in Europe. We also appreciate their recent work regarding the use of tick-borne encephalitis (TBE) vaccine as a neoantigen in patients with primary immunodeficiency. TBE vaccination (TicoVac, Baxter, Berkshire, United Kingdom; FSME-IMMUN, Baxter, Vienna, Austria; or Encepur, Novartis, Basel, Switzerland) is of value in Europe as the disease is endemic in certain countries including China, Japan, and Russia. As the au...
Source: Journal of Allergy and Clinical Immunology - January 2, 2013 Category: Allergy & Immunology Authors: Jordan S. Orange, Rohit Katial Tags: Correspondence Source Type: research