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Specialty: Cytology
Source: Cellular Physiology and Biochemistry

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Total 223 results found since Jan 2013.

MicroRNA-374 Exerts Protective Effects by Inhibiting SP1 Through Activating the PI3K/Akt Pathway in Rat Models of Myocardial Ischemia-Reperfusion After Sevoflurane Preconditioning
Conclusion: The results indicated that miR-374 could alleviate myocardial I/R damage in rat models pretreated with sevoflurane by targeting SP1 by activating the PI3K/Akt pathway.Cell Physiol Biochem 2018;46:1455 –1470
Source: Cellular Physiology and Biochemistry - April 24, 2018 Category: Cytology Source Type: research

Inhibition of LncRNA-HRIM Increases Cell Viability by Regulating Autophagy Levels During Hypoxia/Reoxygenation in Myocytes
Conclusions:LncRNAs are involved in H/R injury of H9c2 myocytes. Inhibition of LncRNA-HRIM increased cell viability by reducing autophagy in myocytes during H/R.Cell Physiol Biochem 2018;46:1341 –1351
Source: Cellular Physiology and Biochemistry - April 24, 2018 Category: Cytology Source Type: research

CLIC1 Promotes the Progression of Gastric Cancer by Regulating the MAPK/AKT Pathways
Conclusions: We speculate that CLIC1 may play an important role in the progression of GC, and its mechanism may be related to the regulation of integrin family proteins, which leads to the sequential regulation of the PI3K/AKT, MAPK/ERK and MAPK/p38 pathways.Cell Physiol Biochem 2018;46:907 –924
Source: Cellular Physiology and Biochemistry - April 18, 2018 Category: Cytology Source Type: research

Palmitate Activates CCL4 Expression in Human Monocytic Cells via TLR4/MyD88 Dependent Activation of NF- κB/MAPK/ PI3K Signaling Systems
Conclusion: Collectively, our results show that palmitate induces CCL4 expression via activation of the TLR4-MyD88/NF-kB/MAPK/ PI3K signaling cascade. Thus, our findings suggest that the palmitate-induced CCL4 production might be an underlying mechanism of metabolic inflammation.Cell Physiol Biochem 2018;46:953 –964
Source: Cellular Physiology and Biochemistry - April 18, 2018 Category: Cytology Source Type: research

Hemeoxygenase-1 Suppresses IL-1 β-Induced Apoptosis Through the NF-κB Pathway in Human Degenerative Nucleus Pulposus Cells
Conclusion: HO-1 might play a significant role in IDD, and HO-1 protected degenerative human NPCs against apoptosis induced by IL-1 β through the NF-κB pathway. These findings would aid in the development of novel therapeutic approaches for IDD treatment.Cell Physiol Biochem 2018;46:644 –653
Source: Cellular Physiology and Biochemistry - April 4, 2018 Category: Cytology Source Type: research

MiR-140 Expression Regulates Cell Proliferation and Targets PD-L1 in NSCLC
Conclusion: We conclude that miR-140 directly suppresses PD-L1 and inhibits the miR-140/PD-L1/cyclin E pathway in NSCLC.Cell Physiol Biochem 2018;46:654 –663
Source: Cellular Physiology and Biochemistry - April 4, 2018 Category: Cytology Source Type: research

Inhibition of SIRT2 Alleviates Fibroblast Activation and Renal Tubulointerstitial Fibrosis via MDM2
Conclusion: Our results suggest that SIRT2 participates in the activation of fibroblasts and TIF, which is mediated via regulation of the MDM2 pathway, and the downregulation of SIRT2 may be a therapeutic strategy for renal fibrosis.Cell Physiol Biochem 2018;46:451 –460
Source: Cellular Physiology and Biochemistry - April 3, 2018 Category: Cytology Source Type: research

Angiotensin II Suppresses Rev-erb α Expression in THP-1 Macrophages via the Ang II Type 1 Receptor/Liver X Receptor α Pathway
Conclusion: Ang II downregulates Rev-erb α expression in THP-1 macrophages via the AT1R/LXRα pathway.Cell Physiol Biochem 2018;46:303 –313
Source: Cellular Physiology and Biochemistry - March 28, 2018 Category: Cytology Source Type: research

PKC ε Increases Extracellular Elastin and Fibulin-5/DANCE in Dermal Fibroblasts
Conclusion: The results of the present study indicate that PKC ε, activated by DCP-LA, increases elastin and fibulin-5/DANCE in the extracellular space of cultured fibroblasts by the mechanism independent of transcriptional and translational modulation or inhibition of elastolysis.Cell Physiol Biochem 2018;46:291 –302
Source: Cellular Physiology and Biochemistry - March 28, 2018 Category: Cytology Source Type: research

Activation of Adenylyl Cyclase Causes Stimulation of Adenosine Receptors
Conclusion: Our findings show that stimulation of adenylyl cyclase causes a remarkable activation of cell surface adenosine receptors.Cell Physiol Biochem 2018;45:2516 –2528
Source: Cellular Physiology and Biochemistry - March 27, 2018 Category: Cytology Source Type: research

Improving Bone Regeneration Using Chordin siRNA Delivered by pH-Responsive and Non-Toxic Polyspermine Imidazole-4,5-Imine
Conclusions: Our results suggest that Chordin is a potential target for improving osteogenesis and bone nonunion therapy and that responsive and non-toxic cationic polyimines such as PSI are therapeutically feasible carriers for the packaging and delivery of Chordin siRNA to hBMSCs.Cell Physiol Biochem 2018;46:133 –147
Source: Cellular Physiology and Biochemistry - March 26, 2018 Category: Cytology Source Type: research

Different Adaptive Responses to Hypoxia in Normal and Multiple Myeloma Endothelial Cells
Conclusion: These findings provide further information on how hypoxia may affect EC survival and could be important for a better understanding of EC physiology under normal and pathological conditions, such as in multiple myeloma.Cell Physiol Biochem 2018;46:203 –212
Source: Cellular Physiology and Biochemistry - March 26, 2018 Category: Cytology Source Type: research

Effects of MiR-375-BMPR2 as a Key Factor Downstream of BMP15/GDF9 on the Smad1/5/8 and Smad2/3 Signaling Pathways
Conclusion: BMP15 and GDF9 have synergistic effects and can act through miR-375 to affect the expression levels of type I receptor ALK4 and type II receptor BMPR2 and the activation of Smad signaling pathway, which subsequently affected the proliferation, spread and apoptosis of cumulus cells.Cell Physiol Biochem 2018;46:213 –225
Source: Cellular Physiology and Biochemistry - March 26, 2018 Category: Cytology Source Type: research

The Effect of and Mechanism Underlying Autophagy in Hepatocellular Carcinoma Induced by CH12, a Monoclonal Antibody Directed Against Epidermal Growth Factor Receptor Variant III
Conclusion: EGFRvIII could induce autophagy, and CH12 treatment could improve autophagy activity in EGFRvIII-positive liver cancer cells. The combination of CH12 with an autophagy inhibitor or siRNA against key proteins in the autophagy pathway displayed more significant efficacy on EGFRvIII-positive tumor cells than monotherapy, and induced cell apoptosis.Cell Physiol Biochem 2018;46:226 –237
Source: Cellular Physiology and Biochemistry - March 26, 2018 Category: Cytology Source Type: research

MicroRNA-183 Acts as a Tumor Suppressor in Human Non-Small Cell Lung Cancer by Down-Regulating MTA1
Conclusion: Our study indicates that miR-183 down-regulates MTA1 to inhibit the proliferation, EMT, migration and invasion of human NSCLC cells.Cell Physiol Biochem 2018;46:93 –106
Source: Cellular Physiology and Biochemistry - March 23, 2018 Category: Cytology Source Type: research