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Source: The American Journal of Chinese Medicine
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Total 82 results found since Jan 2013.
Ruscogenin Alleviates Myocardial Ischemia via Myosin IIA-Dependent Mitochondrial Fusion and Fission Balance
In this study, we observed that RUS markedly reduced MI-induced myocardial injury, as evidenced by notable reductions in infarct size, improvement in biochemical markers, alleviation of cardiac pathology, amelioration of mitochondrial damage, and inhibition of myocardial apoptosis. Moreover, RUS notably suppressed oxygen-glucose deprivation (OGD)-triggered cell injury and apoptosis. Notably, RUS demonstrated a considerable decrease of the interaction between myosin IIA and F-actin, along with the restoration of mitochondrial fusion and fission balance. We further confirmed that the effects of RUS on MI were mediated by myo...
Source: The American Journal of Chinese Medicine - August 31, 2023 Category: Complementary Medicine Authors: Jin-Cheng Liu Qing-Fei Zhao Ling Zhang Bo-Yang Yu Fang Li Jun-Ping Kou Source Type: research
Schisanhenol Attenuates OxLDL-Induced Endothelial Dysfunction via an AMPK-Dependent Mechanism
In this study, human umbilical vein endothelial cells (HUVECs) were pre-treated with SAL and oxLDL. Our results showed that adenosine monophosphate-activated protein kinase (AMPK) phosphorylation was enhanced in cells pre-treated with SAL in time-dependent and dose-dependent manners. Subsequently, oxLDL-induced AMPK dephosphorylation and protein kinase C (PKC) phosphorylation were significantly reversed in the presence of SAL. In addition, SAL treatment led to an inhibiting effect on the oxLDL-induced membrane assembly of NADPH oxidase subunits, and a similar effect was observed in ROS generation. This effect was further c...
Source: The American Journal of Chinese Medicine - July 30, 2023 Category: Complementary Medicine Authors: Tsan-Hung Chiu Chang-Wen Ku Tsung-Jung Ho Kun-Ling Tsai Wei-Ching Hsu Yu-An Chen Hsiu-Chung Ou Hsiu-I Chen Source Type: research
Activation of p62-NRF2 Axis Protects against Doxorubicin-Induced Ferroptosis in Cardiomyocytes: A Novel Role and Molecular Mechanism of Resveratrol
This study showed that DOX decreased cell viability, increased iron accumulation and lipid peroxidation in H9c2 cells; however, these effects were reversed by RSV and ferroptosis inhibitor ferrostatin-1 (Fer-1) pre-treatment. Additionally, RSV significantly increased the cell viability of H9c2 cells treated with ferroptosis inducers Erastin (Era) and RSL3. Mechanistically, RSV inhibited mitochondrial reactive oxygen species (mtROS) overproduction and upregulated the p62-NRF2/HO-1 pathway. RSV-induced NRF2 activation was partially dependent on p62, and the selective inhibition of p62 (using p62-siRNA interference) or NRF2 (...
Source: The American Journal of Chinese Medicine - October 30, 2022 Category: Complementary Medicine Authors: Wei Yu Chunjuan Chen Chenxi Xu De Xie Qiang Wang Weidong Liu Hairong Zhao Furong He Bingyang Chen Yuemei Xi Yunbo Yan Linqian Yu Jidong Cheng Source Type: research
