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Source: Am J Physiol Renal P...
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Total 76 results found since Jan 2013.
The injury-induced transcription factor SOX9 alters the expression of LBR, HMGA2, and HIPK3 in human kidney
Am J Physiol Renal Physiol. 2022 Dec 1. doi: 10.1152/ajprenal.00196.2022. Online ahead of print.ABSTRACTInduction of SRY-box transcription factor 9 (SOX9) has been shown to occur in response to kidney injury in rodents, where SOX9-positive cells proliferate and regenerate the proximal tubules of injured kidneys. Additionally, SOX9-positive cells demonstrate a capacity to differentiate towards other nephron segments. Herein, we characterized the role of SOX9 in normal and injured human kidney. SOX9 expression was found to colocalize with a proportion of the so-called scattered tubular cells (STCs) in uninjured kidney, a cel...
Source: Am J Physiol Renal P... - December 1, 2022 Category: Urology & Nephrology Authors: Michelle Kha Krzysztof Krawczyk Oi Kuan Choong Francesco De Luca G ülay Altiparmak Eva K ällberg Hel én Nilsson Karin Leandersson Karl Sw ärd Martin E Johansson Source Type: research
The hypoxia-inducible factor- α prolyl hydroxylase inhibitor FG4592 ameliorates renal fibrosis by inducing the H3K9 demethylase JMJD1A
Am J Physiol Renal Physiol. 2022 Sep 8. doi: 10.1152/ajprenal.00083.2022. Online ahead of print.ABSTRACTHypoxia-inducible factors 1α and 2α (HIF-1α/2α) transcription factors are the major regulators of the cellular response to hypoxia and also play a key role in renal fibrosis associated with acute and chronic kidney disease. Jumonji domain-containing 1a (JMJD1A), a histone H3 lysine 9 (H3K9) demethylase, is reported to be an important target gene of HIF-α. However, whether JMJD1A and H3K9 methylation status play a role in renal fibrosis is unclear. Here, we investigated the involvement of HIF-α, JMJD1A, and monometh...
Source: Am J Physiol Renal P... - September 8, 2022 Category: Urology & Nephrology Authors: Takeshi Ike Shigehiro Doi Ayumu Nakashima Kensuke Sasaki Naoki Ishiuchi Tomoichiro Asano Takao Masaki Source Type: research
Loss of sphingosine kinase 2 protects against cisplatin induced-kidney injury
Am J Physiol Renal Physiol. 2022 Jul 14. doi: 10.1152/ajprenal.00229.2021. Online ahead of print.ABSTRACTCisplatin is an established chemotherapeutic drug for treatment of solid-organ cancers, and is the primary drug utilized in the treatment of head and neck cancer; however, cisplatin-induced nephrotoxicity largely limits its clinical use. Inhibition of sphingosine kinase 2 (SphK2) has been demonstrated to alleviate various kidney diseases. Therefore, we hypothesized that inhibition of SphK2 could also protect against cisplatin-induced nephrotoxicity. Results from the present study showed that the SphK2 inhibitor, ABC2946...
Source: Am J Physiol Renal P... - July 14, 2022 Category: Urology & Nephrology Authors: Dengpiao Xie Gaizun Hu Chaoling Chen Fereshteh Ahmadinejad Weili Wang Pin-Lan Li David A Gewirtz Ningjun Li Source Type: research
Role of (Pro)Renin Receptor in Cyclosporin A-Induced Nephropathy
Am J Physiol Renal Physiol. 2022 Jan 24. doi: 10.1152/ajprenal.00332.2021. Online ahead of print.ABSTRACTCalcineurin inhibitors (CNIs) such as cyclosporin A (CsA) have been widely used to improve graft survival following solid-organ transplantation. However, the clinical use of CsA is often limited by its nephrotoxicity. The present study tested the hypothesis that activation of (pro)renin receptor (PRR) contributes to CsA-induced nephropathy by activating the renin-angiotensin system (RAS). Renal injury in male Sprague-Dawley rats was induced by a low-salt diet combined with CsA as evidenced by elevated plasma creatinine ...
Source: Am J Physiol Renal P... - January 24, 2022 Category: Urology & Nephrology Authors: Jiajia Hu Yandan Tan Yanting Chen Shiqi Mo Brittin Hekking Jiahui Su Min Pu Aihua Lu J David Symons Tianxin Yang Source Type: research
Decreased IFT88 expression with primary cilia shortening causes mitochondrial dysfunction in cisplatin-induced tubular injury
Am J Physiol Renal Physiol. 2021 Aug 2. doi: 10.1152/ajprenal.00673.2020. Online ahead of print.ABSTRACTThe relevance of primary cilia shortening in kidney disease and its pathomechanism are largely unknown. Tubular damage in acute kidney injury (AKI) is strongly associated with mitochondrial dysfunction. Thus, we investigated the interaction between primary cilia and mitochondria in cisplatin-induced AKI mouse models. We observed that the expression of intraflagellar transport 88 (IFT88), a ciliary maintenance protein, was decreased in the renal cortex following tubular damage due to cisplatin-induced AKI. This result was...
Source: Am J Physiol Renal P... - August 2, 2021 Category: Urology & Nephrology Authors: Rie Fujii Sho Hasegawa Hiroshi Maekawa Tsuyoshi Inoue Kentaro Yoshioka Rie Uni Yoichiro Ikeda Masaomi Nangaku Reiko Inagi Source Type: research
