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Source: Journal of Translational Medicine

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Total 28 results found since Jan 2013.

HERC5 is a prognostic biomarker for post-liver transplant recurrent human hepatocellular carcinoma
Conclusions: HERC5 plays a crucial role in HCC immune evasion and has clinical relevance as a reproducible prognostic marker for risk of tumor recurrence and survival in patients.
Source: Journal of Translational Medicine - December 11, 2015 Category: Research Authors: Feng XueBrandon HiggsJiaqi HuangChris MorehouseWei ZhuXin YaoPhilip BrohawnZhan XiaoYinong SebastianZheng LiuYun XiaDong ShenMike KuzioraZhengwei DongHulin HanYi GuJianren GuQiang XiaYihong Yao Source Type: research

Cyclic helix B peptide inhibits ischemia reperfusion-induced renal fibrosis via the PI3K/Akt/FoxO3a pathway
In this study, we evaluated the effect of CHBP on renal fibrosis in an in vivo ischemia reperfusion injury (IRI) model and in vitro TGF-β-stimulated tubular epithelial cells (TCMK-1 and HK-2) model. In the IRI in vivo model, mice were randomly divided into sham (sham operation), IR and IR + CHBP groups (n = 6). CHBP (8 nmol/kg) was administered intraperitoneally at the onset of reperfusion, and renal fibrosis was evaluated at 12 weeks post-reperfusion. Our results showed that CHBP markedly attenuated the IRI-induced deposition of collagen I and vimentin. In the in vitro model, CHBP reversed the TGF-β-induced down...
Source: Journal of Translational Medicine - November 10, 2015 Category: Research Authors: Cheng YangYe CaoYi ZhangLong LiMing XuYaqiu LongRuiming RongTongyu Zhu Source Type: research

Targeting protein arginine methyltransferase 5 inhibits human hepatocellular carcinoma growth via the downregulation of beta-catenin
Conclusions: PRMT5 plays an important role in HCC. PRMT5 may be a promising target for HCC therapy.
Source: Journal of Translational Medicine - November 5, 2015 Category: Research Authors: Baolai ZhangShuhong DongZhongxin LiLi LuSu ZhangXue ChenXiaobo CenYongjie Wu Source Type: research

SLC39A6: a potential target for diagnosis and therapy of esophageal carcinoma
Conclusions: Combined, our findings highlight a tumor-promoting role for SLC39A6 in ESCC, suggesting that SLC39A6 could serve as an early detector of high-risk subjects and prognostic biomarker. The targeting of SLC39A6 might be a potential therapeutic strategy for blocking ESCC.
Source: Journal of Translational Medicine - October 6, 2015 Category: Research Authors: Xiao-Bin CuiYao-yuan ShenTing-ting JinSu LiTing-ting LiShu-mao ZhangHao PengChun-xia LiuShu-gang LiLan YangNa LiJian-ming HuJin-Fang JiangMan LiWei-hua LiangYong LiYu-tao WeiZhen-zhu SunChuan-yue WuYun-Zhao ChenFeng Li Source Type: research

PEDF and PEDF-derived peptide 44mer stimulate cardiac triglyceride degradation via ATGL
Background: Pigment epithelium-derived factor (PEDF) is a 50-kDa secreted glycoprotein that is highly expressed in cardiomyocytes. A variety of peptides derived from PEDF exerts diverse physiological activities including anti-angiogenesis, antivasopermeability, and neurotrophic activities. Recent studies demonstrated that segmental functional peptides of PEDF, 44mer peptide (Val78–Thr121), show similar neurotrophic and cytoprotective effect to that of the holoprotein. We found that PEDF can reduce infarct size and protect cardiac function after acute myocardial infarction (AMI). However, the effects of PEDF on cardiac tr...
Source: Journal of Translational Medicine - February 21, 2015 Category: Research Authors: Hao ZhangTeng SunXia JiangHongli YuMeng WangTengteng WeiHuazhu CuiWei ZhuangZhiwei LiuZhongming ZhangHongyan Dong Source Type: research

Hypoxia-induced overexpression of stanniocalcin-1 is associated with the metastasis of early stage clear cell renal cell carcinoma
Conclusions: Our findings demonstrate a role for STC1 in metastasis of early stage ccRCC and suggest that STC1 may be a biomarker of potential value both for the prognosis of this disease and for guiding clinical decisions regarding surgical strategies and adjuvant treatment.
Source: Journal of Translational Medicine - February 12, 2015 Category: Research Authors: Xin MaLiangyou GuHongzhao LiYu GaoXintao LiDonglai ShenHuijie GongShichao LiShaoxi NiuYu ZhangYang FanQingbo HuangXiangjun LyuXu Zhang Source Type: research

Fighting against kidney diseases with small interfering RNA: opportunities and challenges
The significant improvements in siRNA therapy have been achieved, which have great potential applications in humans. The kidney is a comparatively easy target organ of siRNA therapy due to its unique structural and functional characteristics. Here, we reviewed recent achievements in siRNA design, delivery and application with focuses on kidney diseases, in particular kidney transplant-related injuries. In addition, the strategy for increasing serum stability and immune tolerance of siRNA was also discussed. At last, the future challenges of siRNA therapy including organ/tissue/cell-specific delivery and time-controlled sil...
Source: Journal of Translational Medicine - February 1, 2015 Category: Research Authors: Cheng YangChao ZhangZitong ZhaoTongyu ZhuBin Yang Source Type: research

NADPH oxidase p47phox siRNA attenuates adventitial fibroblasts proliferation and migration in apoE(-/-) mouse
Conclusion: p47phox plays a critical role in the regulation of adventitial fibroblast proliferation and migration and may be a new therapeutic target for neointimal hyperplasia.
Source: Journal of Translational Medicine - January 28, 2015 Category: Research Authors: Fang XuYing LiuLei ShiWei LiuLi ZhangHongjing CaiJie QiYong CuiWeichen WangYejia Hu Source Type: research

ZBP-89 reduces histone deacetylase 3 by degrading IkappaB in the presence of Pin1
Conclusions: ZBP-89 attenuates HDAC3 by increasing I?B degradation. Such attenuation is independent of NF-?B activity but partially depends on Pin1. The novel pathway identified may help generate new anti-cancer strategy by targeting HDAC3 and its related molecules.
Source: Journal of Translational Medicine - January 27, 2015 Category: Research Authors: Cai YeLiping LiuGeorge ChenXiao TangZhiwei HeMing-Liang HePaul Lai Source Type: research

The association between BMP4 gene polymorphism and its serum level with the incidence of LVH in hypertensive patients
Background: Bone morphogenic proteins 4 (BMP4) is associated with cardiac remodeling under different conditions. However, the role of BMP4 and its gene polymorphism in the incidence of left ventricular hypertrophy (LVH) in hypertensive patients remains unknown. Methods: A total of 1265 patients diagnosed with essential hypertension (EH) were recruited. Patients were assigned to LVH+ (n?=?420) and LVH- (n?=?845) groups. serum BMP4 level was measured and two single nucleotide polymorphism (SNPs) polymorphisms, 6007C?>?T and -5826G?>?A of BMP4 gene were genotyped. We also inhibited the BMP4 by small interfering RNA (siRNA). T...
Source: Journal of Translational Medicine - January 16, 2015 Category: Research Authors: GL GuQY YangRL ZengXL Xu Source Type: research

The role of the globular heads of the C1q receptor in HPV-16 E2-induced human cervical squamous carcinoma cell apoptosis via a mitochondria-dependent pathway
Conclusions: These data support a mechanism whereby gC1qR plays an important role in HPV-16 E2-induced human cervical squamous carcinoma cell apoptosis via a mitochondria-dependent pathway.
Source: Journal of Translational Medicine - October 5, 2014 Category: Research Authors: Zheng-lin ChenYa-juan SuHui-lin ZhangPing-qing GuLing-juan Gao Source Type: research

let-7b/g silencing activates AKT signaling to promote gastric carcinogenesis
Conclusion: In conclusion, our findings reveal decreased let-7b/g contributes to aberrant AKT activation in gastric tumorigenesis and provide a potential therapeutic strategy for gastric cancer.
Source: Journal of Translational Medicine - October 5, 2014 Category: Research Authors: Wei KangJoanna TongRaymond LungYujuan DongWeiqin YangYi PanKin LauJun YuAlfred ChengKa To Source Type: research

Galectin-3 is associated with a poor prognosis in primary hepatocellular carcinoma
Conclusions: These data suggest that galectin-3 plays an important part in HCC progression and may serve as a prognostic factor for HCC.
Source: Journal of Translational Medicine - September 27, 2014 Category: Research Authors: Shan-Shan JiangDe-Sheng WengQi-Jing WangKe PanYao-Jun ZhangYong-Qiang LiJian-Jun LiJing-Jing ZhaoJia HeLin LvQiu-Zhong PanJian-Chuan Xia Source Type: research

The relationship between deiodinase activity and inflammatory responses under the stimulation of uremic toxins
Background: It is unclear to what extent uremic toxins participate in inflammatory responses and the activities of deiodinases, as well as the effects of deiodinases on inflammatory cytokines.Materials and methodsHepatocellular carcinoma cell lines (HepG2) were transfected with small interfering ribonucleic acid (siRNA) specific for deiodinase type 1 (DIO1) and cultured with or without uremic toxins. The mRNA expression of DIO1, interleukin (IL)-1?, IL-6, and tumor necrosis factor (TNF)-? was detected by quantitative real-time PCR. The presence of selenoprotein M (SelM) and DIO1 was assessed by western blotting. Sonicate d...
Source: Journal of Translational Medicine - August 31, 2014 Category: Research Authors: Gaosi XuWeiping TuShulan Qin Source Type: research

Down-regulation of Sp1 suppresses cell proliferation, clonogenicity and the expressions of stem cell markers in nasopharyngeal carcinoma
Conclusions: Sp1 was enriched in advanced NPC tissues and silencing of Sp1 significantly inhibited cell proliferation, clonogenicity, anchorage-independent growth and the stem-cell like phenotype of NPC cells, suggesting Sp1 may serve as an appealing drug target for NPC.
Source: Journal of Translational Medicine - August 7, 2014 Category: Research Authors: Jing-Ping ZhangHua ZhangHong-Bo WangYan-Xian LiGui-Hong LiuShan XingMan-Zhi LiMu-Sheng Zeng Source Type: research