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Source: Cancer Cell International

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Total 35 results found since Jan 2013.

Knock down of TIMP-2 by siRNA and CRISPR/Cas9 mediates diverse cellular reprogramming of metastasis and chemosensitivity in ovarian cancer
The endogenous tissue inhibitor of metalloproteinase-2 (TIMP-2), through its homeostatic action on certain metalloproteinases, plays a vital role in remodelling extracellular matrix (ECM) to facilitate cancer ...
Source: Cancer Cell International - December 30, 2022 Category: Cancer & Oncology Authors: Ruth M. Escalona, Simon Chu, Elif Kadife, Jason K. Kelly, George Kannourakis, Jock K. Findlay and Nuzhat Ahmed Tags: Research Source Type: research

Exploring the relationship between autophagy and Gefitinib resistance in NSCLC by silencing PDLIM5 using ultrasound-targeted microbubble destruction technology
This study investigates novel ultrasound (US) sensitive siRNA-loaded nanobubbles (siRNA-NBs) to explore t...
Source: Cancer Cell International - September 25, 2022 Category: Cancer & Oncology Authors: Yao Zhang, Wenhao Lv, Hui Li, Tiantian Dong, Hao Wu, Chunhong Su, Hong Shu and Fang Nie Tags: Research Source Type: research

Adenovirus-mediated anti-AEG-1 ScFv expression driven by stathmin promoter inhibits tumor growth in cervical cancer
Astrocyte-elevated gene-1 (AEG-1) is over-expressed in many cancer cells and has multiple key functions in tumor initiation and progression. Currently, targeted-AEG-1 siRNA is one of the most common techniques to...
Source: Cancer Cell International - March 12, 2020 Category: Cancer & Oncology Authors: Min Long, Fang Lin, Xi Wang, Xi Chen, Li Liu, Huizhong Zhang and Ke Dong Tags: Primary research Source Type: research

STAT1 inhibits human hepatocellular carcinoma cell growth through induction of p53 and Fbxw7
Conclusions: Our data indicate that STAT1 exerts tumor-suppressive effects in hepatocarcinogenesis through induction of G0/G1 cell cycle arrest and apoptosis, and may provide a basis for the design of new therapies for the intervention of HCC in the clinic.
Source: Cancer Cell International - November 26, 2015 Category: Cancer & Oncology Authors: Jiayu ChenHaihe WangJing WangShishun HuangWei Zhang Source Type: research

Eukaryotic translation initiation factor 5A2 (eIF5A2) regulates chemoresistance in colorectal cancer through epithelial mesenchymal transition
Conclusion: Our present study demonstrated that eIF5A2 promoted the chemoresistance to doxorubicin via regulation of EMT in colon cancer cells. Therefore, eIF5A2 inhibition may be a new potential strategy for the reversal of drug resistance in colorectal cancer therapy.
Source: Cancer Cell International - November 17, 2015 Category: Cancer & Oncology Authors: Ying BaoYongliang LuXiang WangWenming FengXinrong SunHuihui GuoChengwu TangXiaojing ZhangQilin ShiHongbin Yu Source Type: research

Time depended Bcl-2 inhibition might be useful for a targeted drug therapy
Conclusions: However, we showed here a time dependent blocking of the bcl-2 transcript that might lead to cell dead due autophagy, and not necessarily to apoptosis.
Source: Cancer Cell International - November 2, 2015 Category: Cancer & Oncology Authors: Abdolhassan TalaiezadehFateme jalaliHamid GalehdariAli Khodadadi Source Type: research

MicroRNA-125b promotes tumor metastasis through targeting tumor protein 53-induced nuclear protein 1 in patients with non-small-cell lung cancer
Conclusions: These findings demonstrated that miR-125b promoted tumor metastasis via targeting TP53INP1 in human NSCLC cells, which uncovered a real clinical relevance of microRNAs in tumor biology, and provided novel potential candidates for NSCLC clinical practice.
Source: Cancer Cell International - September 17, 2015 Category: Cancer & Oncology Authors: Qinchuan LiYang HanChunhong WangShan ShanYuanyuan WangJingang ZhangTao Ren Source Type: research

Inhibition of CDK4/6 as a novel therapeutic option for neuroblastoma
Conclusion: Selective inhibition of CDK4/6 using palbociclib may provide a new therapeutic option for treating neuroblastoma.
Source: Cancer Cell International - July 30, 2015 Category: Cancer & Oncology Authors: Ali RihaniJo VandesompeleFrank SpelemanTom Van Maerken Source Type: research

B-cell receptor-guided delivery of peptide-siRNA complex for B-cell lymphoma therapy
Conclusions: Peptide-siRNA complex can be suitable tool for both selective peptide-driven cell targeting and gene silencing. In this setting, the improvement of this strategy is expected to provide a safe and non-invasive approach for the delivery of therapeutic molecules.
Source: Cancer Cell International - May 7, 2015 Category: Cancer & Oncology Authors: Nunzia MigliaccioCamillo PalmieriImmacolata RuggieroGiuseppe FiumeNicola MartucciIris ScalaIleana QuintoGiuseppe ScalaAnnalisa LambertiPaolo Arcari Source Type: research

MiR-124 suppresses cell motility and adhesion by targeting talin 1 in prostate cancer cells
Conclusions: Our study demonstrated biological roles and the related mechanism of miR-124 in prostate cancer. The results indicate that talin 1 is very likely a novel player in the anti-metastatic signaling network of miR-124. By down-regulation of talin 1, miR-124 impairs the adhesion, migration, and invasion of prostate cancer cells.
Source: Cancer Cell International - May 6, 2015 Category: Cancer & Oncology Authors: Wei ZhangYe-qing MaoHua WangWen-juan YinShao-xing ZhuWei-cheng Wang Source Type: research

SLPI knockdown induced pancreatic ductal adenocarcinoma cells proliferation and invasion
Background: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease and still continues to have the worst prognosis of all gastrointestinal malignancies. Reports have demonstrated that secretory leukocyte protease inhibitor (SLPI) is overexpressed in various cancers and may be a potential therapeutic strategy for the treatment of different cancers. However, the possible role of SLPI in PDAC is still unknown. In the present study, we investigate the effects of SLPI gene knockdown on the biological behavior of human pancreatic cancer cells. The expressions of SLPI were detected, by qRT-PCR and Western blot, in human...
Source: Cancer Cell International - April 1, 2015 Category: Cancer & Oncology Authors: Wei ZhangJian-Long YaoShan-Chao DongFeng-Qiang HouHe-Ping Shi Source Type: research

BCYRN1, a c-MYC-activated long non-coding RNA, regulates cell metastasis of non-small-cell lung cancer
Conclusion: These findings uncover a regulatory mechanism in NSCLC cells involving the metastasis-promoting lncRNA BCYRN1 that improves expressions of the key metastasis-supporting proteins MMP9 and MMP13.
Source: Cancer Cell International - April 1, 2015 Category: Cancer & Oncology Authors: Tao HuYu-Run Lu Source Type: research

The association between Salt-inducible kinase 2 (SIK2) and gamma isoform of the regulatory subunit B55 of PP2A (B55gamma) contributes to the survival of glioma cells under glucose depletion through inhibiting the phosphorylation of S6K
Conclusion: In summary, our project will provide novel insight into the design and development of therapeutic strategies to target the B55gamma-mediated glucose metabolism for the treatment of human brain tumor patients.
Source: Cancer Cell International - February 18, 2015 Category: Cancer & Oncology Authors: Ya-nan LiYi-qun CaoXi WuGuo-sheng HanLai-xing WangYu-hui ZhangXin ChenBin HaoZhi-jian YueJian-min Liu Source Type: research

Arf6 regulates EGF-induced internalization of E -cadherin in breast cancer cells
E-cadherin internalization facilitates dissolution of adherens junctions and promotes tumor cell epithelial-mesenchymal transition (EMT) and migration. Our previous results have shown that Arf6 exerts pro-migratory action in breast cancer cells after EGF stimulation. Despite the fact that EGF signaling stimulates EMT of breast cancer cells, the effect of Arf6 on internalization of E-cadherin of breast cancer cells under EGF treatment remains to be determined. Here, we showed that EGF dose-dependently stimulated E-cadherin internalization by MCF-7 cells with the maximal effect at 50?ng/ml. Meanwhile, EGF treatment markedly ...
Source: Cancer Cell International - February 4, 2015 Category: Cancer & Oncology Authors: Rui XuYujie ZhangLuo GuJianchao ZhengJie CuiJing DongJun Du Source Type: research

Histone deacetylase 6 activity is critical for the metastasis of Burkitt¿s lymphoma cells
Conclusions: We identified a critical role of HDAC6 in the metastasis of Burkitt?s lymphoma cells, suggesting that pharmacological inhibition of HDAC6 could be a promising strategy for the management of metastatic Burkitt?s lymphoma.
Source: Cancer Cell International - December 5, 2014 Category: Cancer & Oncology Authors: Ning DingLingyan PingLixia FengXiaohui ZhengYuqin SongJun Zhu Source Type: research