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Activation of MMP ‐9 by membrane type‐1 MMP/MMP‐2 axis stimulates tumor metastasis
An artificial receptor for proMMP‐9 was created by fusing tissue inhibitor of MMP‐1 (TIMP‐1) with type II transmembrane mosaic serine protease (MSP‐T1). Expression of MSP‐T1 in 293T cells induced binding of proMMP‐9, which was processed by MMP‐2 activated by membrane type 1 MMP (MT1‐MMP). HT1080 cells transfected with the MSP‐T1 gene produced activated MMP‐9 in collagen gel, and addition of proMMP‐2 to the culture augmented it, which resulted in intensive collagen digestion. These cells metastasized into chick embryonic liver more than control cells. Treatment of HT1080 cells with concanavalin A in th...
Source: Cancer Science - March 15, 2017 Category: Cancer & Oncology Authors: Zichen Li, Takahisa Takino, Yoshio Endo, Hiroshi Sato Tags: Original Article Source Type: research

Activation of Matrix Metalloproteinase (MMP) ‐9 by Membrane‐Type‐1 Matrix Metalloproteinase/MMP‐2 axis Stimulates Tumor Metastasis
This article is protected by copyright. All rights reserved.
Source: Cancer Science - December 16, 2016 Category: Cancer & Oncology Authors: Zichen Li, Takahisa Takino, Yoshio Endo, Hiroshi Sato Tags: Original Article Source Type: research