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Gonadotropin-releasing hormone type II (GnRH-II) agonist regulates the invasiveness of endometrial cancer cells through the GnRH-I receptor and mitogen-activated protein kinase (MAPK)-dependent activation of matrix metalloproteinase (MMP)-2
Conclusion: Our study indicates that GnRH-II agonist promoted cell motility of endometrial cancer cells through the GnRH-I receptor via the phosphorylation of ERK1/2 and JNK, and the subsequent, MAPK-dependent activation of MMP-2. Our findings represent a new concept regarding the mechanism of GnRH-II-induced cell motility in endometrial cancer cells and suggest the possibility of exploring GnRH-II as a potential therapeutic target for the treatment of human endometrial cancer.
Source: BMC Cancer - June 20, 2013 Category: Cancer & Oncology Authors: Hsien-Ming WuHsin-Shih WangHong-Yuan HuangChyong-Huey LaiChyi-Long LeeYung-Kuei SoongPeter Leung Source Type: research

Evaluation of a curcumin analog as an anti-cancer agent inducing ER stress-mediated apoptosis in non-small cell lung cancer cells
Conclusions: A new monocarbonyl analog of curcumin, B82, exhibited anti-tumor effects on H460 cells via an ER stress-mediated mechanism. B82 could be further explored as a potential anticancer agent for the treatment of NSCLC.
Source: BMC Cancer - October 24, 2013 Category: Cancer & Oncology Authors: Zhiguo LiuYusheng SunLuqing RenYi HuangYuepiao CaiQiaoyou WengXueqian ShenXiaokun LiGuang LiangYi Wang Source Type: research

Ionizing radiation induces tumor cell lysyl oxidase secretion
Conclusions: These results indicate a differential regulation of LOX-expression and secretion in response to IR and hypoxia, and suggest that LOX may contribute towards an IR-induced migratory phenotype in sublethally-irradiated tumor cells and tumor progression.
Source: BMC Cancer - July 22, 2014 Category: Cancer & Oncology Authors: Colette ShenAshish SharmaDinh-Van VuongJanine ErlerMartin PruschyAngela Broggini-Tenzer Source Type: research