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NT-16 * NANOPARTICLE-MEDIATED DELIVERY OF ANTI-Ape1 siRNA SENSITIZES PEDIATRIC BRAIN TUMOR CELLS TO RADIATION THERAPY BY INHIBITING DNA REPAIR
Pediatric brain tumors are the leading cause of death in children, and survival is frequently accompanied by one or more radiation-induced adverse developmental and psychosocial sequelae. Radiotherapy (RT) is an integral component of the treatment for medulloblastoma (MB) and the only effective adjuvant therapy for ependymoma (EP). Therefore, there is an urgent need to develop strategies to enhance the tumoricidal action of RT while sparing adjacent normal tissue. The multifunctional DNA repair protein Ape1/Ref-1 has been implicated in conferring radiation resistance in pediatric brain tumors. However, inhibiting Ape1 acti...
Source: Neuro-Oncology - November 3, 2014 Category: Cancer & Oncology Authors: Kievit, F., Stephen, Z., Wang, K., Dayringer, C., Ellenbogen, R., Silber, J., Zhang, M. Tags: NOVEL THERAPEUTICS (CLINICAL AND/OR LABORATORY RESEARCH) Source Type: research

Rt-40 * the down-regulation of h-ferritin as an adjuvant therapy in human glioma
This study supports the potential of H-ferritin siRNA as an adjuvant therapy in glioma treatment.
Source: Neuro-Oncology - November 3, 2014 Category: Cancer & Oncology Authors: Pang, M., Liu, X., Madhankumar, A. B., Slagle-Webb, B., Connor, J. Tags: RADIATION THERAPY (CLINICAL AND/OR LABORATORY RESEARCH) Source Type: research

TR-04 * NANOPARTICLE siRNA DELIVERY VEHICLES INHIBIT DNA REPAIR AND SENSITIZE PEDIATRIC BRAIN TUMOR CELLS TO RADIATION THERAPY
Source: Neuro-Oncology - April 23, 2015 Category: Cancer & Oncology Authors: Kievit, F., Stephen, Z., Wang, K., Dayringer, C., Silber, J., Ellenbogen, R., Zhang, M. Tags: TRANSLATIONAL THERAPEUTICS Source Type: research