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Source: Breast Cancer Research

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Total 16 results found since Jan 2013.

Dual inhibition of Type I and Type III PI3 kinases increases tumor cell apoptosis in HER2+ breast cancers
Conclusions: These studies highlight the important role of Vps34-mediated autophagy in limiting the anti-tumor response to inhibitors of HER2 or type I PI3K in HER2+ breast cancers. The type III PI3K Vps34 represents a potential therapeutic target to block treatment-induced autophagy and enhance tumor cell killing.
Source: Breast Cancer Research - December 4, 2015 Category: Cancer & Oncology Authors: Christian YoungCarlos ArteagaRebecca Cook Source Type: research

Preclinical evaluation of cyclin dependent kinase 11 and casein kinase 2 survival kinases as RNA interference targets for triple negative breast cancer therapy
Conclusions: CDK11 and CK2 expression are individually essential for breast cancer cell survival, including TNBC. These genes serve as promising new targets for therapeutic development in breast cancer.
Source: Breast Cancer Research - February 11, 2015 Category: Cancer & Oncology Authors: Betsy KrenGretchen UngerMd AbedinRachel VogelChristine HenzlerKhalil AhmedJaneen Trembley Source Type: research

Targeting interferon response genes sensitizes aromatase inhibitor resistant breast cancer cells to estrogen-induced cell death
Conclusion: Overall, these results demonstrate that constitutive overexpression of ISGs enhances the progression of AI-resistant breast cancer and that suppression of IFITM1 and other ISGs sensitizes AI-resistant cells to estrogen-induced cell death.
Source: Breast Cancer Research - January 15, 2015 Category: Cancer & Oncology Authors: Hye ChoiAsona LuiJoshua OgonyRifat JanPeter SimsJoan Lewis-Wambi Source Type: research

A co-culture genome-wide RNAi screen with mammary epithelial cells reveals transmembrane signals required for growth and differentiation
Conclusion: Diverse transmembrane signals are required for mammary epithelial cell growth in 2D and 3D conditions. Strikingly, we define novel roles for axonal pathfinding receptors and ligands and the endothelin receptor in both growth and differentiation.
Source: Breast Cancer Research - January 9, 2015 Category: Cancer & Oncology Authors: Angela BurleighSteven McKinneyJazmine BrimhallDamian YapPeter EirewSteven PoonViola NgAdrian WanLeah PrenticeLois AnnabJ BarrettCarlos CaldasConnie EavesSamuel Aparicio Source Type: research

Profiling gene promoter occupancy of Sox2 in two phenotypically distinct breast cancer cell subsets using chromatin immunoprecipitation and genome-wide promoter microarrays
Conclusions: In conclusion, our data supports the model that the Sox2 induces differential gene expression in the two distinct cell subsets in BC, and contributes to their phenotypic differences.
Source: Breast Cancer Research - November 8, 2014 Category: Cancer & Oncology Authors: Karen JungPeng WangNidhi GuptaKeshav GopalFang WuXiaoxia YeAbdulraheem AlshareefGilbert BigrasTodd McMullenBassam AbdulkarimRaymond Lai Source Type: research

Trefoil factor 3 promotes metastatic seeding and predicts poor survival outcome of patients with mammary carcinoma AU Query: Please confirm the address additions or amend accordingly.
Conclusions: TFF3 expression predicts metastasis and poor survival outcome of patients with MC and functionally stimulates cellular invasion and metastasis of ER?+?MC cells. Adjuvant functional inhibition of TFF3 may therefore be considered to ameliorate outcome of ER?+?MC patients.
Source: Breast Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Vijay PandeyZheng-Sheng WuMin ZhangRui LiJian ZhangTao ZhuPeter Lobie Source Type: research

Tamoxifen induces apoptosis through cancerous inhibitor of protein phosphatase 2A dependent phospho-Akt inactivation in estrogen-receptor negative human breast cancer cells
Conclusions: Inhibition of CIP2A determines the effects of tamoxifen-induced apoptosis in ER-negative breast cancer cells. Our data suggest a novel ?off-target? mechanism of tamoxifen and suggest that CIP2A/PP2A/p-Akt signaling as a feasible anti-cancer pathway.
Source: Breast Cancer Research - September 17, 2014 Category: Cancer & Oncology Authors: Chun-Yu LiuMan-Hsin HungDuen-Shian WangPei-Yi ChuJung-Chen SuTsung-Han TengChun-Teng HuangTing-Ting ChaoCheng-Yi WangChung-Wai ShiauLing-Ming TsengKuen-Feng Chen Source Type: research

Mitochondrial dysfunction in some triple-negative breast cancer cell lines: role of mTOR pathway and therapeutic potential
Conclusions: Our study shows that TNBC cells have profound metabolic alterations characterized by decreased mitochondrial respiration and increased glycolysis. Due to their impaired mitochondrial function, TNBC cells are highly sensitive to glycolytic inhibition, suggesting that such metabolic intervention may be an effective therapeutic strategy for this subtype of breast cancer cells.
Source: Breast Cancer Research - September 11, 2014 Category: Cancer & Oncology Authors: Hélène PelicanoWan ZhangJinyun LiuNaima HammoudiJiale DaiRui-hua XuLajos PusztaiPeng Huang Source Type: research

Profiling the tyrosine phosphoproteome of different mouse mammary tumour models reveals distinct, model-specific signaling networks and conserved oncogenic pathways
Conclusion: This study provides network-level insights into signaling in these breast cancer models and demonstrates that comparative phosphoproteomics can identify conserved oncogenic signaling pathways. The Met-amplified, p53-null tumours provide a new pre-clinical model for a subset of triple-negative breast cancers.
Source: Breast Cancer Research - September 9, 2014 Category: Cancer & Oncology Authors: Naveid AliJianmin WuFalko HochgräfeHoward ChanRadhika NairSunny YeLuxi ZhangRuth LyonsMark PineseHong LeeNicola ArmstrongChristopher OrmandySusan ClarkAlexander SwarbrickRoger Daly Source Type: research

P2Y2 receptor activation by nucleotides released from highly metastatic breast cancer cells increases tumor growth and invasion via crosstalk with endothelial cells
Conclusion: This study suggests that P2Y2R may play an important role in cancer metastasis via modulation of the crosstalk between cancer cells and ECs.
Source: Breast Cancer Research - August 26, 2014 Category: Cancer & Oncology Authors: Hana JinSo EunJong LeeSang ParkJae LeeKi ChangHye Kim Source Type: research

Transforming growth factor beta receptor type III is a tumor promoter in mesenchymal-stem like triple negative breast cancer
Conclusions: We have found that TbetaRIII is required for migration and invasion in vitro and xenograft growth in vivo. We also show that TbetaRIII-KD elevates expression of integrin-alpha2, which is required for the reduced migration and invasion, as determined by siRNA knockdown studies of both TbetaRIII and integrin-alpha2. Overall, our results indicate a potential mechanism in which TbetaRIII modulates integrin-alpha2 expression to effect MSL cell migration, invasion, and tumorigenicity.
Source: Breast Cancer Research - July 1, 2014 Category: Cancer & Oncology Authors: Bojana Jovanovi¿J BeelerMichael PickupAnna ChytilAgnieszka GorskaWilliam AshbyBrian LehmannAndries ZijlstraJennifer PietenpolHarold Moses Source Type: research

Estrogen receptor beta as a novel target of androgen receptor action in breast cancer cell lines
Conclusions: Collectively, these data provide evidence for a novel mechanism by which activated AR, through an up-regulation of ER-beta gene expression, inhibits breast cancer cell growth.
Source: Breast Cancer Research - February 19, 2014 Category: Cancer & Oncology Authors: Pietro RizzaInes BaroneDomenico ZitoFrancesca GiordanoMarilena LanzinoFrancesca De AmicisLoredana MauroDiego SisciStefania CatalanoKarin Dahlman WrightJan-ake GustafssonSebastiano Andò Source Type: research

Transforming growth factor-ß signalling controls human breast cancer metastasis in a zebrafish xenograft model
Conclusions: The zebrafish-embryonic breast cancer xenograft model is applicable for the mechanistic understating, screening and development of anti-TGF-beta drugs for the treatment of metastatic breast cancer in a timely and cost-effective manner.
Source: Breast Cancer Research - November 7, 2013 Category: Cancer & Oncology Authors: Yvette DrabschShuning HeLong ZhangB Snaar-JagalskaPeter ten Dijke Source Type: research

Transforming growth factor beta signalling controls human breast cancer metastasis in a zebrafish xenograft model
Conclusions: The zebrafish-embryonic breast cancer xenograft model is applicable for the mechanistic understating, screening and development of anti-TGF-beta drugs for the treatment of metastatic breast cancer in a timely and cost-effective manner.
Source: Breast Cancer Research - November 7, 2013 Category: Cancer & Oncology Authors: Yvette DrabschShuning HeLong ZhangB Snaar-JagalskaPeter ten Dijke Source Type: research

Novel sorafenib analogues induce apoptosis through SHP-1 dependent STAT3 inactivation in human breast cancer cells
Conclusions: Novel sorafenib analogues SC-1 and SC-43 induce apoptosis through SHP-1 dependent STAT3 inactivation and demonstrate greater potency than sorafenib in human breast cancer cells.
Source: Breast Cancer Research - August 12, 2013 Category: Cancer & Oncology Authors: Chun-Yu LiuLing-Ming TsengJung-Chen SuKung-Chi ChangPei-Yi ChuWei-Tien TaiChung-Wai ShiauKuen-Feng Chen Source Type: research