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Source: Am J Physiol Cell Ph...
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Sex differences in the involvement of skeletal and cardiac muscles in myopathic Ano5 < sup > -/- < /sup > mice
Am J Physiol Cell Physiol. 2022 Jan 12. doi: 10.1152/ajpcell.00350.2021. Online ahead of print.ABSTRACTLimb-girdle muscular dystrophy R12 (LGMD-R12) is caused by recessive mutations in the Anoctamin-5 gene (ANO5, TMEM16E). Although ANO5 myopathy is not X-chromosome linked, we performed a meta-analysis of the research literature and found that three-quarters of LGMD-R12 patients are males. Females are less likely to present with moderate to severe skeletal muscle and/or cardiac pathology. Because these sex differences could be explained in several ways, we compared males and females in a mouse model of LGMD-R12. This model ...
Source: Am J Physiol Cell Ph... - January 12, 2022 Category: Cytology Authors: Steven Foltz Fang Wu Nasab Ghazal Jennifer Q Kwong H Criss Hartzell Hyojung J Choo Source Type: research
