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Extrahepatic effects of nucleoside and nucleotide analogues in chronic hepatitis B treatment
Abstract Oral nucleoside/nucleotide analogues (NAs) are the mainstay of therapy for patients with chronic hepatitis B and are generally well tolerated. Despite this, the safety profile of NAs is of paramount importance since the majority of patients will require long‐term treatment. All NAs can potentially affect human DNA polymerase with decrease in mitochondrial DNA, leading to manifestations of mitochondrial toxicity. As a class effect, therefore, NAs can potentially cause extrahepatic conditions, such as myopathy, nephropathy, neuropathy, and lactic acidosis. Indeed, effects on muscles, including myopathy and creatin...
Source: Journal of Gastroenterology and Hepatology - February 19, 2014 Category: Gastroenterology Authors: James Fung, Wai‐Kay Seto, Ching‐Lung Lai, Man‐Fung Yuen Tags: Review Source Type: research

Extra‐hepatic Effects of Nucleoside and Nucleotide Analogues in Chronic Hepatitis B Treatment
Abstract Oral nucleoside/nucleotide analogues (NAs) are the mainstay of therapy for patients with chronic hepatitis B, and are generally well tolerated. Despite this, the safety profile of NAs is of paramount importance since the majority of patients will require long‐term treatment. All NAs can potentially affect human DNA polymerase with decrease in mitochondrial DNA, leading to manifestations of mitochondrial toxicity. As a class effect therefore, NAs can potentially cause extra‐hepatic conditions such as myopathy, nephropathy, neuropathy, and lactic acidosis. Indeed, effects on muscles including myopathy and creati...
Source: Journal of Gastroenterology and Hepatology - December 27, 2013 Category: Gastroenterology Authors: James Fung, Wai‐Kay Seto, Ching‐Lung Lai, Man‐Fung Yuen Tags: Solicited Review Source Type: research