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Neurological Adverse Events Determine Morbidity and Mortality Post Allogeneic Hematopoietic Cell Transplantation
Conclusions: Our large retrospective study highlights the wide spectrum of manifestations and etiologies of neurological complications in alloHCT recipients. Prompt diagnosis is required for adequate management, a major of determinant of survival. Thus, long-term increased awareness and collaboration between expert physicians is warranted to improve patient outcomes.Figure.DisclosuresGavriilaki: European Hematology Association: Research Funding. Vardi: Janssen: Honoraria; Gilead: Research Funding.
Source: Blood - November 21, 2018 Category: Hematology Authors: Sakellari, I., Gavriilaki, E., Papagiannopoulos, S., Gavriilaki, M., Batsis, I., Mallouri, D., Vardi, A., Constantinou, V., Iskas, M., Masmanidou, M., Yannaki, E., Geroukis, T., Kazis, D., Kimiskidis, V., Anagnostopoulos, A. Tags: 723. Clinical Allogeneic and Autologous Transplantation: Late Complications and Approaches to Disease Recurrence Source Type: research

Comprehensive Analysis of Systemic Immunosuppression (SIS) Duration after Allogeneic Hematopoietic Stem Cell Transplant: Risk Score Model Provides Stratification of Patients According to Probability of SIS Discontinuation
CONCLUSIONS:Older age, bone marrow as a source of stem cells, T-cell depletion, matched related donor and a full matched donor increase the likelihood of discontinuation of SIS after allogeneic HCT. In addition, the severity of aGVHD and cGVHD significantly affects the chance of SIS discontinuation. The proposed risk score stratifies patients into well-defined groups according to the chance of SIS discontinuation. Further studies in a larger number of patients are strongly recommended to validate this finding. Prospective validation is also warranted to confirm the utility of the risk score as a clinical tool for estimatio...
Source: Blood - November 21, 2018 Category: Hematology Authors: Bautista, M. R., Law, A., Lam, W., Michelis, F. V., Thyagu, S., Viswabandya, A., Kumar, R., Lipton, J. H., Messner, H. A., Kim, D. D. H. Tags: 722. Clinical Allogeneic Transplantation: Acute and Chronic GVHD, Immune Reconstitution: Poster II Source Type: research