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Source: Experimental Lung Research
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Total 35 results found since Jan 2013.
Inhibition of cGAS aggravated the host inflammatory response to < em > Aspergillus fumigatus < /em >
Conclusion: Based on our analysis, we conclude that activating cGAS might increase host resistance to A. fumigatus, protect against pulmonary illnesses brought on by A. fumigatus and that exploring the cGAS-STING signaling pathway is beneficial not only for the immunological investigation of IPA but also may be a potential therapeutic objective.PMID:37190937 | DOI:10.1080/01902148.2023.2211663
Source: Experimental Lung Research - May 16, 2023 Category: Respiratory Medicine Authors: Mei Peng Xiujun Li Xiaobing Zhang Li Peng Source Type: research
TGF- β-induced CCR8 promoted macrophage transdifferentiation into myofibroblast-like cells
Conclusions: Our findings showed that the macrophages exposed to TGF-β had the potential to transdifferentiate into myofibroblasts and CCR8 was involved in the process. The effect of CCR8 on TGF-β-induced macrophage transdifferentiation occurs mainly through autophagy. Targeting CCR8 may be a novel therapeutic strategy for the treatment of IPF.PMID:35377281 | DOI:10.1080/01902148.2022.2055227
Source: Experimental Lung Research - April 4, 2022 Category: Respiratory Medicine Authors: Haijun Liu Qingzhou Guan Peng Zhao Jiansheng Li Source Type: research
