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Specialty: Epidemiology
Source: Adv Data

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Total 18 results found since Jan 2013.

pH-sensitive, tail-modified, ester-linked ionizable cationic lipids for gene delivery
Biomater Adv. 2022 Jun 14;139:212984. doi: 10.1016/j.bioadv.2022.212984. Online ahead of print.ABSTRACTIonizable cationic lipids have great potential for gene delivery, yet the effect of the molecular structure of such lipids on gene delivery efficiency is an ongoing research challenge. To better understand corresponding structure-function activity relationships, we synthesized four ester-linked, pH-responsive, ionizable cationic lipids. The screened DEDM4 lipid, containing 2-ethylenedimethylamine in the headgroup and a branched-chain tail, exhibited a high delivery efficacy of plasmid DNA and siRNA in A549 cells, which wa...
Source: Adv Data - July 26, 2022 Category: Epidemiology Authors: Yu Zou Yuhong Zhen Yinan Zhao Huiying Chen Rui Wang Wei Wang Pengfei Ma Defu Zhi Benzhi Ju Shubiao Zhang Source Type: research

Colored petri net modeling of small interfering RNA-mediated messenger RNA degradation.
CONCLUSION: In previous studies, a network of stoichiometric equations was modeled. However, in this particular study, we modeled the mechanism behind the silencing process. Modeling this kind of mechanisms provides us with a tool to examine the effects of different factors such as mutation or drugs on the process. PMID: 27376039 [PubMed]
Source: Adv Data - July 6, 2016 Category: Epidemiology Authors: Nickaeen N, Moein S, Heidary Z, Ghaisari J Tags: Adv Biomed Res Source Type: research

Suppression of VEGF by Reversible-PEGylated Histidylated Polylysine in Cancer Therapy.
Abstract A reversible-PEGylated polylysine is designed and developed for efficient delivery of siRNA. In this unique structure, the ε-amino groups of disulfide linked poly(ethylene glycol) (PEG) and polylysine (mPEG-SS-PLL) are partially replaced by histidine groups, in order to develop the histidylated reversible-PEGylated polylysine (mPEG-SS-PLH), for enhanced endosome escape ability. The transfection efficacy of mPEG-SS-PLH is found to closely correlate with histidine substitution. Its maximum transfection efficiencies are determined, respectively, to be 75%, 42%, and 24%, against 293T, MCF-7, and PC-3 cells. ...
Source: Adv Data - May 7, 2014 Category: Epidemiology Authors: Cai X, Zhu H, Dong H, Li Y, Su J, Shi D Tags: Adv Healthc Mater Source Type: research