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Ectopic adrenocorticotrophic hormone syndrome secondary to treatment-related neuroendocrine differentiation of metastatic castrate-resistant prostate cancer
Endocrinol Diabetes Metab Case Rep. 2023 Jan 1;2023:22-0347. doi: 10.1530/EDM-22-0347. Online ahead of print.ABSTRACTSUMMARY: A 64-year-old man with progressive metastatic castrate-resistant prostate adenocarcinoma presented with recurrent fluid overload, severe hypokalaemia with metabolic alkalosis and loss of glycaemic control. Clinical features were facial plethora, skin bruising and proximal myopathy. Plasma adrenocorticotrophic hormone (ACTH), serum cortisol and 24-h urinary cortisol levels were elevated. Low-dose dexamethasone failed to suppress cortisol. Pituitary MRI was normal and 68Gallium-DOTATATE PET-CT scan sh...
Source: Cancer Control - January 10, 2023 Category: Cancer & Oncology Authors: Chelsea Tan Jessica Triay Source Type: research
