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Cancers, Vol. 14, Pages 5367: The Histone Methyltransferase SETD8 Regulates the Expression of Tumor Suppressor Genes via H4K20 Methylation and the p53 Signaling Pathway in Endometrial Cancer Cells
We examined the expression profile of SETD8 and evaluated whether SETD8 plays a critical role in the proliferation of endometrial cancer cells using small interfering RNAs (siRNAs). We identified the prognostically important genes regulated by SETD8 via H4K20 methylation and p53 signaling using chromatin immunoprecipitation sequencing, RNA sequencing, and machine learning. We confirmed that SETD8 expression was elevated in endometrial cancer tissues. Our in vitro results suggest that the suppression of SETD8 using siRNA or a selective inhibitor attenuated cell proliferation and promoted the apoptosis of endometrial cancer ...
Source: Cancers - October 31, 2022 Category: Cancer & Oncology Authors: Asako Kukita Kenbun Sone Syuzo Kaneko Eiryo Kawakami Shinya Oki Machiko Kojima Miku Wada Yusuke Toyohara Yu Takahashi Futaba Inoue Saki Tanimoto Ayumi Taguchi Tomohiko Fukuda Yuichiro Miyamoto Michihiro Tanikawa Mayuyo Mori-Uchino Tetsushi Tsuruga Takayuk Tags: Article Source Type: research

Cancers, Vol. 13, Pages 3903: Identification of CNGB1 as a Predictor of Response to Neoadjuvant Chemotherapy in Muscle-Invasive Bladder Cancer
Rakesh Heer Cisplatin-based neoadjuvant chemotherapy (NAC) is recommended prior to radical cystectomy for muscle-invasive bladder cancer (MIBC) patients. Despite a 5–10% survival benefit, some patients do not respond and experience substantial toxicity and delay in surgery. To date, there are no clinically approved biomarkers predictive of response to NAC and their identification is urgently required for more precise delivery of care. To address this issue, a multi-methods analysis approach of machine learning and differential gene expression analysis was undertaken on a cohort of 30 MIBC cases highly selected for an...
Source: Cancers - August 2, 2021 Category: Cancer & Oncology Authors: Anastasia C. Hepburn Nicola Lazzarini Rajan Veeratterapillay Laura Wilson Jaume Bacardit Rakesh Heer Tags: Article Source Type: research