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Lead toxicity in Lucilia cuprina and electrochemical analysis: a simple and low-cost alternative for forensic investigation
This study describes for the first time the toxicity analysis of Pb on immature L. cuprina through their survival rate and influence of Pb on immature development. In addition, the bioaccumulation of Pb in the larvae samples was determined based on square wave anodic stripping voltammetry (SWASV) measurements. The results revealed a low limit of detection to Pb (6.5 μg L-1) and the analytical performance was satisfactory because it measures Pb levels in larvae exposed to a diet containing 50 μg Pb g-1. Furthermore, the levels of Pb influenced the survival rate and development time of the immature L. cuprina. Larvae expos...
Source: Analytical and Bioanalytical Chemistry - March 5, 2021 Category: Chemistry Authors: B árbara G de O Bessa Habdias de A Silva-Neto Wendell K T Coltro Thiago L Rocha Welinton R Lopes Source Type: research

An integrated approach to unravel a crucial structural property required for the function of the insect steroidogenic Halloween protein Noppera-bo Protein Structure and Folding
Ecdysteroids are the principal steroid hormones essential for insect development and physiology. In the last 18 years, several enzymes responsible for ecdysteroid biosynthesis encoded by Halloween genes were identified and genetically and biochemically characterized. However, the tertiary structures of these proteins have not yet been characterized. Here, we report the results of an integrated series of in silico, in vitro, and in vivo analyses of the Halloween GST protein Noppera-bo (Nobo). We determined crystal structures of Drosophila melanogaster Nobo (DmNobo) complexed with GSH and 17β-estradiol, a DmNobo inhibitor. ...
Source: Journal of Biological Chemistry - May 14, 2020 Category: Chemistry Authors: Kotaro Koiwai, Kazue Inaba, Kana Morohashi, Sora Enya, Reina Arai, Hirotatsu Kojima, Takayoshi Okabe, Yuuta Fujikawa, Hideshi Inoue, Ryunosuke Yoshino, Takatsugu Hirokawa, Koichiro Kato, Kaori Fukuzawa, Yuko Shimada-Niwa, Akira Nakamura, Fumiaki Yumoto, T Tags: Enzymology Source Type: research

Development and validation of a new TD-GC/MS method and its applicability in the search for human and animal decomposition products.
This study describes the development and validation of a new analytical method that can be applied in the search of such (a) specific marker(s). Sampling of the volatile compounds released by decomposing animal and human remains was performed both in a laboratory environment and outdoors by adsorption on sorbent tubes. Different coatings and several sampling parameters were investigated. Next, the volatile compounds were analyzed and identified by a thermal desorber combined with gas chromatography coupled to mass spectrometry (TD-GC/MS). Different GC columns were tested. Finally, the analytical method was validated using ...
Source: Analytical and Bioanalytical Chemistry - March 16, 2014 Category: Chemistry Authors: Rosier E, Cuypers E, Dekens M, Verplaetse R, Develter W, Van de Voorde W, Maes D, Tytgat J Tags: Anal Bioanal Chem Source Type: research

Identification of Dactylopius cochineal species with high-performance liquid chromatography and multivariate data analysis
In this study, validated species of...The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Analyst latest articles - August 1, 2013 Category: Chemistry Authors: Ana Filipa Serrano Source Type: research