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Total 347 results found since Jan 2013.

Real-World Safety and Efficacy of Biosimilar CT-P13 in Patients with Immune-Mediated Inflammatory Diseases: Integrated Analysis of Three Japanese Prospective Observational Studies
ConclusionsThe integrated analysis of a large number of patients detected no new safety signals with long-term CT-P13 treatment. Efficacy in rheumatoid arthritis, psoriasis, Crohn ’s disease, and ulcerative colitis cases was confirmed in biologic-naïve patients and switched patients from the originator infliximab or other biologics.
Source: Drug Safety - September 12, 2023 Category: Drugs & Pharmacology Source Type: research

News at a glance: Muscular dystrophy therapy, lab-grown chicken, and humans ’ toll on wildlife
BIOMEDICINE Muscular dystrophy therapy approved The U.S. Food and Drug Administration has approved the first gene therapy for Duchenne muscular dystrophy (DMD), a genetic disease that cripples boys and usually results in death by age 30. The treatment from Sarepta Therapeutics introduces a short version of the gene for dystrophin, a crucial muscle protein, which is mutated in patients with DMD. A one-time intravenous infusion of a virus delivers the functioning “microdystrophin” gene into patients’ muscle cells. The 22 June approval is only for boys 4 to 5 years old, a group that appeared likely to ben...
Source: Science of Aging Knowledge Environment - June 29, 2023 Category: Geriatrics Source Type: research

AI Cough-Monitoring Can Change the Way We Diagnose Disease
How many times do you cough a day? Do you cough more when you’re indoors or outside? Or more often after you eat? Or at night? Chances are, your cough memory might not be that accurate. But all of that information about your coughing patterns could be an untapped resource to better understand your health. Coughs may be benign ways to clear a little extra phlegm, or they could be early signs of more serious conditions such as asthma, GERD (gastroesophageal reflux disease), or even lung cancer. “In the era of precision health, it’s ironic that such a problematic symptom is simply unmeasured,” says Pet...
Source: TIME: Health - April 3, 2023 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized healthscienceclimate Technology Source Type: news

Dysregulation of Immunity in Pulmonary Fibrosis is Associated with Increased Myeloid-specific Triggering Receptor-1 and Transforming Growth Factor-beta1 Expression
In this study, the expression of triggering receptor expressed on myeloid cells-1 (TREM-1) as a stimulator for the production of TGF-β1 and also CD4+CD25+Foxp3+ regulatory cells were investigted in FP patients. Sixteen UIP, 14 NSIP and 4 pulmonary fibrosis following Mycobacterium tuberculosis (TB) infection patients, were compared with 12 healthy controls. The frequency of blood CD14+TGF-β1+ and CD14+TREM1+-gated monocytes and CD4+CD25+Foxp3+ regulatory T cells (Treg), as well as the plasma levels of TGF-β1 and IL‑10 were measured. Fibrosis patients compared to healthy controls had a greater frequency of CD14+TGF-β1+...
Source: Iranian Journal of Allergy, Asthma and Immunology - April 1, 2023 Category: Allergy & Immunology Authors: Shima Rasouli Jalal Heshmatnia Nariman Mosaffa Majid Marjani Esmaeil Mortaz Source Type: research