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Regulation of NADPH oxidase NOX4 by delta iodolactone (IL- δ) in thyroid cancer cells
Conclusions The antiproliferative and pro-apoptotic effect of IL-δ is mediated by different mechanisms and pathway involving different sources of ROS generation depending on the cellular context. Graphical abstract
Source: Molecular and Cellular Endocrinology - May 27, 2018 Category: Endocrinology Source Type: research

Estrogen receptor beta signaling inhibits PDGF induced human airway smooth muscle proliferation
In this study, we evaluated the effect of selective ERα and ERβ modulators on platelet-derived growth factor (PDGF)-stimulated ASM proliferation and the mechanisms involved. Asthmatic and non-asthmatic primary human ASM cells were treated with PDGF, 17β-estradiol, ERα-agonist and/or ERβ-agonist and/or G-protein-coupled estrogen receptor 30 (GPR30/GPER) agonist and proliferation was measured using MTT and CyQuant assays followed by cell cycle analysis. Transfection of small interfering RNA (siRNA) ERα and ERβ significantly altered the human ASM proliferation. The specificity of siRNA transfection was confirmed by Wes...
Source: Molecular and Cellular Endocrinology - April 20, 2018 Category: Endocrinology Source Type: research

SIRT1 suppresses high glucose and palmitate-induced osteoclast differentiation via deacetylating p66Shc
In conclusion, this study confirms the role of DM in osteoclast differentiation in vitro. SIRT1 suppresses HG- and PA-induced osteoclast differentiation via p66Shc/ROS/NF-κB signaling.
Source: Molecular and Cellular Endocrinology - February 25, 2018 Category: Endocrinology Source Type: research

MXRA5 is decreased in preeclampsia and affects trophoblast cell invasion through the MAPK pathway
This study sought to explore the role of MXRA5 in trophoblast cell invasion. Preeclamptic villi were obtained for the delineation of MXRA5 expression. Specific MXRA5 siRNA and pcDNA3.1/MXRA5 were used to manipulate MXRA5 expression in HTR-8/SVneo. Cell viability was determined by MTT and apoptosis by flow cytometry. Cell invasion was evaluated using Matrigel invasion assay. MXRA5 expression was lower in preeclamptic villi and cytotrophoblasts. Silencing MXRA5 expression in HTR-8/SVneo decreased cell viability and invasion, which were augmented by MXRA5 overexpression. Furthermore, MXRA5 modulated N-cadherin, E-cadherin, MM...
Source: Molecular and Cellular Endocrinology - January 29, 2018 Category: Endocrinology Source Type: research

Bazedoxifene and raloxifene protect neocortical neurons undergoing hypoxia via targeting ER α and PPAR-γ
This study provides prospects for the development of a new therapeutic strategies against hypoxic brain injury that selectively target ERα and/or PPAR-γ.
Source: Molecular and Cellular Endocrinology - August 31, 2017 Category: Endocrinology Source Type: research

Role of brain-derived neurotrophic factor and nerve growth factor in the regulation of Neuropeptide W in vitro and in vivo
Publication date: Available online 27 February 2017 Source:Molecular and Cellular Endocrinology Author(s): Rikang Wang, Fengxia Yan, Rifang Liao, Pei Wan, Peter J. Little, Wenhua Zheng Nerve growth factor (NGF) and Brain-derived neurotrophic factor (BDNF) are neurotrophic factors involved in the growth, survival and functioning of neurons. In addition, a possible role of neurotrophins, particularly BDNF, in HPA axis hyperactivation has recently been proposed. Neuropeptide W (NPW) is an endogenous peptide ligand for the GPR7 and GPR8 and a stress mediator in the hypothalamus. It activates the HPA axis by working on hypotha...
Source: Molecular and Cellular Endocrinology - February 26, 2017 Category: Endocrinology Source Type: research

SNAREs and cholesterol movement for steroidogenesis
Publication date: 5 February 2017 Source:Molecular and Cellular Endocrinology, Volume 441 Author(s): Fredric B. Kraemer, Wen-Jun Shen, Salman Azhar Steroidogenesis is a complex process through which cholesterol traffics to mitochondria and is converted via a series of enzymatic steps to steroid hormones. Although the rate-limiting step in this process is the movement of cholesterol from the outer to the inner mitochondrial membrane via the actions of StAR, a continuous supply of cholesterol must be delivered to the outer mitochondrial membrane during active steroidogenesis and this is derived from multiple sources, includ...
Source: Molecular and Cellular Endocrinology - January 8, 2017 Category: Endocrinology Source Type: research

β-arrestins regulate gonadotropin receptor-mediated cell proliferation and apoptosis by controlling different FSHR or LHCGR intracellular signaling in the hGL5 cell line
In this study, we used the human granulosa cell line hGL5 to demonstrate how follicle-stimulating hormone (FSH) and luteinizing hormone (LH) differently control proliferative or apoptotic signals, revealing novel intrinsic properties of their receptors (FSHR, LHCGR). We found that, in this tumor-like cell line, the expression of endogenous FSHR and LHCGR is serum-dependent, but both receptors were unable to activate the canonical cAMP/PKA pathway upon gonadotropin stimulation, failing to produce cAMP, progesterone and G protein-coupled receptor (GPCR)-mediated apoptosis in vitro. Conversely, ligand treatment resulted in F...
Source: Molecular and Cellular Endocrinology - August 10, 2016 Category: Endocrinology Source Type: research

Endoplasmic reticulum stress regulates inflammation and insulin resistance in skeletal muscle from pregnant women
Publication date: 15 April 2016 Source:Molecular and Cellular Endocrinology, Volume 425 Author(s): Stella Liong, Martha Lappas Sterile inflammation and infection are key mediators of inflammation and peripheral insulin resistance associated with gestational diabetes mellitus (GDM). Studies have shown endoplasmic reticulum (ER) stress to induce inflammation and insulin resistance associated with obesity and type 2 diabetes, however is paucity of studies investigating the effects of ER stress in skeletal muscle on inflammation and insulin resistance associated with GDM. ER stress proteins IRE1α, GRP78 and XBP-1s were up...
Source: Molecular and Cellular Endocrinology - March 3, 2016 Category: Endocrinology Source Type: research

Endoplasmic reticulum stress regulates inflammation and insulin resistance in pregnant skeletal muscle
Publication date: Available online 20 February 2016 Source:Molecular and Cellular Endocrinology Author(s): Stella Liong, Martha Lappas Sterile inflammation and infection are key mediators of inflammation and peripheral insulin resistance associated with gestational diabetes mellitus (GDM). Studies have shown endoplasmic reticulum (ER) stress to induce inflammation and insulin resistance associated with obesity and type 2 diabetes, however is paucity of studies investigating the effects of ER stress in skeletal muscle on inflammation and insulin resistance associated with GDM. ER stress proteins IRE1α, GRP78 and XBP-1s...
Source: Molecular and Cellular Endocrinology - February 20, 2016 Category: Endocrinology Source Type: research

Melatonin enhances arsenic trioxide-induced cell death via sustained upregulation of Redd1 expression in breast cancer cells
Publication date: Available online 27 November 2015 Source:Molecular and Cellular Endocrinology Author(s): Sun-Mi Yun, Sang Hyeok Woo, Sang Taek Oh, Sung-Eun Hong, Tae-Boo Choe, Sang-Kyu Ye, Eun-Kyu Kim, Min Ki Seong, Hyun-A Kim, Woo Chul Noh, Jin Kyung Lee, Hyeon-Ok Jin, Yun-Han Lee, In-Chul Park Melatonin is implicated in various physiological functions, including anticancer activity. However, the mechanism(s) of its anticancer activity is not well understood. In the present study, we investigated the combined effects of melatonin and arsenic trioxide (ATO) on cell death in human breast cancer cells. Mela...
Source: Molecular and Cellular Endocrinology - November 27, 2015 Category: Endocrinology Source Type: research

Epidermal Growth Factor: Porcine Uterine Luminal Epithelial Cell Migratory Signal during the Peri-implantation Period of Pregnancy
Publication date: Available online 24 November 2015 Source:Molecular and Cellular Endocrinology Author(s): Wooyoung Jeong, Seoungo Jung, Fuller W. Bazer, Gwonhwa Song, Jinyoung Kim The majority of early conceptus mortality in pregnancy occurs during the peri-implantation period, suggesting that this period is important for conceptus viability and the establishment of pregnancy. Successful establishment of pregnancy in all mammalian species depends on the orchestrated molecular events that transpire at the conceptus-uterine interface during the peri-implantation period of pregnancy. This maternal-conceptus interactio...
Source: Molecular and Cellular Endocrinology - November 24, 2015 Category: Endocrinology Source Type: research

C1q/TNF-related protein-9 inhibits cytokine-induced vascular inflammation and leukocyte adhesiveness via AMP-activated protein kinase activation in endothelial cells
Publication date: Available online 31 October 2015 Source:Molecular and Cellular Endocrinology Author(s): Chang Hee Jung, Min Jung Lee, Yu Mi Kang, Yoo La Lee, So Mi Seol, Hae Kyeong Yoon, Sang-Wook Kang, Woo Je Lee, Joong-Yeol Park Although recent studies have reported cardioprotective effects of C1q/TNF-related protein 9 (CTRP9), the closet adiponectin paralog, its role on cytokine-induced endothelial inflammation is unknown. We investigated whether CTRP9 prevented inflammatory cytokine-induced nuclear factor-kappa B (NF-κB) activation and inhibited the expression of adhesion molecules and a chemokine in the ...
Source: Molecular and Cellular Endocrinology - October 31, 2015 Category: Endocrinology Source Type: research

Expression, regulation and function of Hmgn3 during decidualization in mice
Publication date: 15 September 2015 Source:Molecular and Cellular Endocrinology, Volume 413 Author(s): Dang-Dang Li, Chuan-Hui Guo, Liang Yue, Cui-Cui Duan, Zhan-Qing Yang, Hang Cao, Bin Guo, Zhan-Peng Yue Although Hmgn3 is involved in the regulation of development and cellular differentiation, its physiological roles on decidualization are still unknown. Here we showed that Hmgn3 was highly expressed in the decidua and decidualizing stromal cells. Overexpression of Hmgn3 variants, Hmgn3a or Hmgn3b, enhanced the expression of decidualization markers Prl8a2 and Prl3c1, whereas inhibition of Hmgn3 reduced their exp...
Source: Molecular and Cellular Endocrinology - July 31, 2015 Category: Endocrinology Source Type: research

Rosiglitazone inhibition of calvaria-derived osteoblast differentiation is through both of PPARγ and GPR40 and GSK3β-dependent pathway
This study aims to investigate the effects of RSG on differentiation and mineralization of osteoblasts using primary cultured mouse fetal calvaria-derived osteoblasts as a model, and elucidate the receptor and signaling pathways responsible for these effects. We found that RSG suppressed the differentiation and mineralization of calvaria-derived osteoblasts. Peroxisome proliferators-activated receptor γ (PPARγ) siRNA significantly reversed the inhibitory effect of RSG on osteogenic differentiation. The expression of G protein-coupled receptor (GPR) 40 was suppressed during differentiation, but was increased by RSG treatm...
Source: Molecular and Cellular Endocrinology - July 31, 2015 Category: Endocrinology Source Type: research

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